Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Hair cycle"”.
-
Exploring Molecular Mechanisms Controlling Skin Homeostasis and Hair Growth. MicroRNAs in Hair-cycle-Dependent Gene Regulation, Hair Growth and Associated Tissue Remodelling.
The hair follicle (HF) is a cyclic biological system that progresses through stages of growth, regression and quiescence, each being characterized by unique patterns of gene activation and silencing. MicroRNAs (miRNAs) are critically important for gene silencing and delineating their role in hair …
-
Coordinating Stem Cell Behavior in the Hair Follicle
… tear or in response to acute injury. Remarkably, hair follicles naturally undergo repetitive cycles of regeneration and degeneration, a process that is accomplished with the support of stem cells within the hair follicles. It is this feature that makes this miniorgan an attractive model system to …
-
Specification And Function Of Early Hair Follicle Stem Cells
… reside in a quiescent niche associated with each hair follicle termed the "bulge" and are essential for cyclic bouts of hair growth. Bulge stem cells can also contribute to sebaceous glands and the intefollicular epidermis when it is injured. While hair follicles begin to develop during …
-
A Comparison of Cultured Human Dermal Fibroblasts Derived from Terminal and Vellus Hair Bearing Skin. Differences in the expression of inhibitors of apoptosis proteins, oestrogen receptors, and responses to oestradiol under normal and wound induced conditions
Wounds heal better in skin with terminal hair follicles (large and pigmented) as opposed to those with vellus hair follicles (small and unpigmented), while dermal fibroblasts from different anatomical regions also exhibit phenotypical differences. Tissue repair requires a tight control of cell …
-
The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme
… important role during the morphogenesis of the hair follicle and the hair cycle. Work on hair regeneration is of importance as no products are available which can provide complete reversal of hair loss. Tet2 promotes DNA demethylation by the hydroxylation of 5mC to 5hmC which in turn causes gene …
-
Molecular Regulation of Hair Follicle Morphogenesis
… cells during embryogenesis. Morphogenesis of hair follicles is initiated when a series of reciprocal interactions between this undifferentiated ectoderm and its underlying mesenchyme leads to a localized invagination of epithelial cells. As hair follicle development proceeds, stem cells are …
-
Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
… All Epi-Insig-DKO mice failed to grow body hair, had decreased body weights, and died 6 weeks after birth. Early hair follicle development was normal while later development was disrupted and led to hair cycle arrest in these mice. Skin from these mutant mice showed a significant buildup of …
-
EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
… and revealed that abrogation of EGFR disrupts hair follicle cycling. Hair follicles transition between the anagen growth phase, a transitional catagen phase, and the dormant phase of telogen throughout life. We hypothesized that the defect in progression through catagen resulting from EGFR …
-
Not Black and White: BMP Signaling Drives Melanocyte Differentiation Downstream of Stem Cell Activation
… crest-derived SC population located in the hair follicle (HF). Through periodic bouts synchronous with HF cycling, quiescent McSCs become activated to proliferate, giving rise to committed proliferative progeny (McCP) that differentiate into mature pigment-producing melanocytes. The …
-
The role of miRNA-486-5p in hair growth and the hair follicle immune privilege
… their role in regulation of apoptosis and hair loss in alopecia areata (AA) is largely unknown, which became the aim of this study. In AA mouse model (C3H/HeJ), global miRNA profiling revealed 22 miRNAs with significant changes in their expression in AA affected skin. Amongst these miRNAs, …
-
Development of inducible transgenic mouse models for melanoma
… confirmation of N-Raslys61 expression following hair plucking to initiate the hair cycle and anagen melanocytes proliferation, therefore PTENflx/flx mutation was introduced. Unexpectedly, a similar result was obtained following treatment of EICre/PTENflx/flx/N-Raslys61 and EICre/PTENflx/flx in …