Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"Haemostasis"”.
-
The effects of hypothermia and acidosis on Haemostasis
… corrected. It is possible that global assays of haemostasis may offer some insight into the pathology of hypothermia and acidosis. However, as always in science many more questions are raised than are answered.
-
Redox Regulation of Haemostasis; Modulation by Inspiratory Hypoxia and Physical Exercise
Introduction: Haemostasis is the arrest of bleeding. In recent years, in-vitro studies have suggested that secondary haemostasis (blood coagulation) is subject to activation by reactive oxygen species (ROS). It is known that patients who suffer from vascular disease are typically hypoxaemic and in …
-
Inflammation and haemostasis in the development and progression of peripheral atherosclerotic disease
… was to examine 12 markers of inflammation and haemostasis in relation to peripheral atherosclerotic progression and incident PAD. The Edinburgh Artery Study was used for this analysis. This is a population based cohort study of 1,592 men and women recruited in 1987. ABI was measured at baseline …
-
Investigating the role of rare genetic variants in the aetiology of haemostasis disorders
… principal cell types functionally implicated in haemostasis. I also generated chromatin conformation maps for the relevant genes using a capture Hi-C approach. Finally, I characterised the captured sequences by annotating them with cell type-specific epigenomic features, and I experimentally …
-
Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease
… factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality of life …
-
Development and Characterisation of a Vessel-On-a-Chip Model of Inflammation and Inflammatory Haemostasis
… model to explore their role in inflammation, and haemostasis of leaky vessels. In unstimulated vessels, platelets were protective, reducing leakage of small molecules. However, in inflamed vessels, platelets played a dual role, promoting permeability and enhancing neutrophil transmigration, whilst …
-
Thyroid hormonal axis as a significant regulator of haemostasis // Тироидната хормонална ос - значим регулатор на хемостазата
Дисертационният труд е посветен на актуален за медицинската теория и практика проблем. Проучва се влиянието на хормоните на тироидната ос - TRH (Thyrotropin releasing hormone), TSH (Thyroid stimulating hormone), T3 (Trijodthyroninum) и Т4 (Thyroxin) върху хемостазата у плъхове. Използвани са 1027 …
-
The influence of carrageenans on the cells and pathways of haemostasis and their role in immunosuppression
Carrageenans are a group of galactan sulphates derived from marine Rhodophyceae. These polymers have been shown to exert a variety of pharmacological effects, several of which involve alterations in both immune and haemostatic responses. Carrageenans were studied for the following …
-
Roles of coagulation factor XIII in the functions of blood platelets
Haemostasis is initiated following blood vessel injury to preclude loss of blood. It involves concerted actions of blood platelets and soluble coagulation factors in forming blood clots at sites of vascular injury. Platelets are recruited from flowing blood and become activated to fulfil their …
-
Genetic and functional studies in inherited platelet disorders
… granules, which play a critical role in haemostasis, atherogenesis, thrombosis, and wound healing. Platelet number, volume, and function are genetically regulated, and genome wide association studies have identified more than 1000 loci associated with platelet traits. Common variants, …
-
Role of matrix metalloproteinases in regulation of late embryonic healing process
… complex, longer, and is divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling phase. Adult wound healing might end with the scar. Pivotal role in the wound healing is given to matrix metalloproteinases (MMPs). These remodelling enzymes are important for releasing …
-
A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… Willebrand factor (VWF) levels. Abnormalities in haemostasis are implicated in CTEPH pathobiology, including elevated levels of VWF, which is cleaved by ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). The ADAMTS13-VWF axis was investigated in 208 CTEPH …
-
Platelets : their exploitation and elimination
… to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that platelets play significant roles in both innate and adaptive immunity, inflammatory responses including leukocyte migration, tissue regeneration and angiogenesis. …
-
Platelets : their exploitation and elimination
… to be limited to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that platelets play significant roles in both innate and adaptive immunity, inflammatory responses including leukocyte migration, tissue regeneration and angiogenesis. …
-
Sulfatides mediate Disabled-2 membrane localization and stability during platelet aggregation
… thus, they are thought to play a major role in haemostasis and thrombogenesis. Here, we show that the Dab2 PTB domain specifically interacts with sulfatides through two conserved basic motifs. The sulfatide-binding site overlaps with that of phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) …
-
Studies of calcium signalling mechanisms in human platelets
Platelet activation is essential in haemostasis and thrombosis and central to this role is cytosolic calcium (Ca2+) elevation. The two ways in which this can occur are release from intracellular Ca2+ stores and the entry of Ca2+ across the plasma membrane (PM). Changes in cytosolic Ca2+ are …
-
Novel blood platelet diagnostic platform
… platelet aggregation to maintain physiological haemostasis. Any abnormality in platelet functionality induces thrombus or atherosclerotic plaques leading to life-threatening consequences such as stroke. Recent reports suggest that the detection of activated platelets in the blood may be a useful …
-
Engineering rFVIIa-loaded platelets; a novel approach to treating acute bleeding
… clot formation, as well as an in vivo model of haemostasis to compare their efficacy to conventional treatments. Overall, this serves as a proof of concept of the engineering of platelet granules as a novel drug delivery system.
-
Targeting integrin alpha 5 and focal adhesion kinase to overcome azacitidine resistance in higher risk myelodysplastic syndromes
… inflammatory pathways, platelet aggregation and haemostasis pathways ultimately priming HSPCs for haematopoietic differentiation. Together, my thesis supports the role of inhibiting integrin alpha 5 and focal adhesion kinase to re-sensitise azacitidine resistant HSPCs to azacitidine that could be …
-
A study of platelets and the endothelium in idiopathic pulmonary fibrosis
… and function. In addition to their role in haemostasis, platelets have significant inflammatory and pro-fibrotic potential. Platelets and the lung have a close relationship in physiology and in disease however the role of platelets in IPF has not previously been investigated.In this thesis …
Page 1 of 3