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Showing 1 to 20 of 78 for “"Haemophilus"”.
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Haemophilus influenzae as a chassis for directed endosymbiosis
… between distinct species. This thesis explores Haemophilus influenzae as a candidate chassis for directed endosymbiosis with Saccharomyces cerevisiae. H. influenzae is small, genetically tractable, naturally competent for DNA uptake, facultatively intracellular, and dependent on host-relevant …
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Haemophilus influenzae adhesins and the innate immune response
Haemophilus influenzae is a human specific Gram-negative respiratory tract pathogen. Encapsulated H. influenzae strains exist in six different serotypes a-f, of which type b (Hib) is the most virulent. Hib is protected by the polysaccharide capsule when invading the blood circulaton and may cause …
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Studies of the NAD metabolism of Haemophilus influenzae
Haemophilus influenzae, as well as other members of the genus which require V-factor, display a unique growth requirement for intact NAD. This organism, the primary cause of bacterial meningitis, is incapable of synthesis of pyridine nucleotides from the usual precursors. An externally directed …
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Antigenic Characterization of <I>Haemophilus somnus</I> Lipooligosaccharide
… membranes, including pathogenic species of <I>Haemophilus</I> and <I>Neisseria</I>. LOS phase variation is one mechanism by which some of these bacteria avoid the host immune response. To better understand LOS phase variation as a virulence mechanism of <I>H. somnus</I>, knowledge of the …
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Studies on pyridine nucleotide-dependent processes in Haemophilus influenzae
Haemophilus influenzae and related species have a unique requirement for externally-provided NAD; therefore, several pyridine nucleotide-requiring enzymes become important for the survival of these pathogens. Haemophilus influenzae ATP:NMN adenylyltransferase was partially purified 15-fold with a …
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HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS INTRA- AND INTERSPECIES QUORUM SIGNALING
… instance, the leading causative agents <italic>Haemophilus influenzae</italic> and <italic>Moraxella catarrhalis</italic> are more frequently found to coexist than to be isolated individually. Polymicrobial infection and biofilm formation may have a dramatic impact on the severity and …
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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae
Haemophilus influenzae is an important respiratory tract pathogen responsible for a variety of infections in humans. Encapsulated H. influenzae belongs to one of six serotypes (a-f), of which type b is the most virulent one causing serious and sometimes life-threatening diseases (e.g., …
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Comparative and Functional Genomic Studies of Histophilus somni (Haemophilus somnus)
Histophilus somni is a commensal of the mucosal surfaces of respiratory and reproductive tracts of cattle and sheep. However, as an opportunistic pathogen, H. somni can cause diseases such as pneumonia, myocarditis, abortion, arthritis, and meningo-encephalitis. Previously, several virulence …
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Charakterisierung der initialen Aufnahme des Kofaktors V (NAD) bei Haemophilus influenzae
H. influenzae ist ein fakultativ anaerobes, Gram-negatives Bakterium und wird in die Familie der Pasteurellacaea eingeordnet. Das Bakterium zeigt Auxotrophien für Hämin unter aeroben Bedingungen und für Nikotinamid-Adenin-Dinukleotid (NAD) bei aeroben wie anaeroben Wachstum. Es können zwei …
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A mathematical model to describe haemophilus influenzae type B within Western Australia
This work is primarily aimed at determining the effect that an immunisation policy Is likely to have on the incidence of Haemophllus influenzae Type B (HIB) and systematic HIB in Western Australia. There was a significant effort made to collect data pertinent to the estimation of parameter values …
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Charakterisierung von NadR : das essentielle Enzym der NAD-Synthese bei Haemophilus influenzae
I Zusammenfassung Haemophilus influenzae, ein Gram-negatives, Bakterium der Familie Pasteurellaceae, kann beim Menschen eine Vielzahl an Erkrankungen auslösen: Die bekapselte Stämme, v. a. mit Typ b Kapsel können Cellulitis, septische Arthritis, Epiglottitis und Meningitis verursachen. Die …
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The effect of antibiotic treatment on Haemophilus parasuis colonization, disease and immunity
Glasser's disease is an important source of economic losses in commercial swine production systems. The success of controlled exposure in the field suggests that early exposure (colonization) with pathogenic H. parasuis protects pigs from Glasser's disease. However, little is known about the immune …
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<i>Haemophilus influenzae</i> modulins in chronic obstructive pulmonary disease airway inflammation
<p>Nontypeable <em>H. influenzae</em> (NTHi) causes repeated respiratory infections characterized by a brisk inflammatory response that results in the expression and secretion of proinflammatory cytokines. We hypothesized that secreted and cell asssociated NTHi proteins mediate cellular …
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Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates
… phenotypically diverse bacterium nontypeable <i>Haemophilus influenzae</i> (NTHi) is a leading cause of otitis media (OM). This disease affects children around the world. Treatment is complicated by the ability of the bacteria to form biofilms in which they are more tolerant to antimicrobials. …
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The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to …
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ΜΕΛΕΤΗ ΠΑΡΑΜΕΤΡΩΝ ΕΓΚΕΦΑΛΟΝΩΤΙΑΙΟΥ ΥΓΡΟΥ ΣΕ ΘΕΡΑΠΕΙΑ ΠΕΙΡΑΜΑΤΙΚΗΣ ΜΗΝΙΓΓΙΤΙΔΑΣ ΑΠΟ HAEMOPHILUS INFLUENZAE TYPE B
… AND VARIOUS TREATMENT MODALITIES IN EXPERIMENTAL HAEMOPHILUS INFLUENZAE TYPE B (HIB) MENINGITIS WERE ASSESSED. IN THE FIRST PART THE ROLE OF HIB CAPSULE AND LIPOPOLYSACCHARIDE IN THE INDUCTION OF MENNIGEAL INFLAMMATION WERE EVALUATED. A MINIMAL INFLAMMATORYRESPONSE WAS FOUND FOLLOWING …
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Purification and characterization of malate dehydrogenase and 6- phosphogluconate dehydrogenase from Haemophilus influenzae
Haemophilus influenzae, the primary causative factor in bacterial meningitis, displays a unique growth requirement for intact NAD. Selective inhibitors of the pyridine nucleotide-requiring enzymes from H. influenzae could have a pronounced effect on growth of the organism. Haemophilus malate …
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Cloning and Characterization of a Gene Involved in Lipooligosaccharide Biosynthesis in Haemophilus somnus
… lipooligosaccharide (LOS) phase variation in Haemophilus influenzae type b (Hib). In an attempt to identify H. somnus phase-variable LOS genes, the presence of CAAT repeats within the H. somnus 738 genome was confirmed using a (CAAT)7 probe. A 3.9 kb EcoRI fragment that reacted with the probe …
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Investigation of Haemophilus somnus Virulence Factors: Lipooligosaccharide Sialylation and Inhibition of Superoxide Anion Production
… strains of the bovine opportunistic pathogen Haemophilus somnus (Histophilus somni) cause multi-systemic diseases in cattle. One of the reported virulence factors that H. somnus may use to persist in the host is resistance to intracellular killing. It is reported in this dissertation that H. …
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