Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Haemophilia"”.
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Haemophilia 2010; an exploration of the lived experience of boys with haemophilia
… of psychosocial research into living with haemophilia from a child’s perspective. Published works focus predominantly on the impact of HIV infection which occurred in the mid 1980’s. Since then treatment has been improved and intensified so that most children with severe haemophilia are …
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MOLECULAR GENETICS OF HAEMOPHILIA A IN SINGAPORE
As the DNA polymorphisms of haemophilia A are influenced by ethnic variations, an initial population study is required in the major ethnic groups in Singapore. This could help to lead to the development of a more sophisticated genetic diagnosis programme through linkage analysis to be established …
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The lived experience of haemophilia and impact of gene therapy on the haemophilia patient community and their families : the Exigency programme
… the potential to change the lives of people with haemophilia, offering, if not a complete cure, then a significant reduction in treatment burden and an improvement in overall quality of life. Little is known, however, about the lived experiences of those who have undergone gene therapy or the …
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Health-Related Quality of Life and Adherence in Haemophilia
… of health-related quality of life (HRQoL) in haemophilia is important in order to provide information for clinical decision making and to verify the impact of haemophilia on patients and their families. Advances in haemophilia care and prophylactic treatment have improved HRQoL for the …
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COMPUTATIONAL APPROACHES IN STUDYING INHIBITOR DEVELOPMENT IN HAEMOPHILIA A PATIENTS
L'emofilia A è un disturbo emorragico recessivo legato al cromosoma X, causato da mutazioni nel gene F8, che determinano una carenza o un malfunzionamento del fattore VIII (FVIII) della coagulazione. Una delle principali complicazioni cliniche nei casi gravi è lo sviluppo di alloanticorpi …
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Becoming and being mother to a boy with severe haemophilia.
Haemophilia is a recessive genetic disorder which manifests symptoms in males but is carried by females. The disordered coagulation associated with severe haemophilia causes atraumatic joint and muscle bleeds and prolonged mucosal bleeding. These acute bleeding episodes frequently occur without any …
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The experiences of caregivers caring for patients with haemophilia in rural areas
Some patients with haemophilia from rural areas miss most of their clinic appointments and visit a clinic only when the complications of haemophilia have already set in. The observations from the daily practice motivated the researcher to investigate the experiences of caregivers caring for …
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ADVANCED AAV-MEDIATED LIVER-DIRECTED GENE THERAPIES FOR HAEMOPHILIA A AND MUCOPOLYSACCHARIDOSIS TYPE VI
… manner. I used this approach for haemophilia A (HemA), the most common X-linked bleeding disorder (affecting 1 in 5,000 males), caused by a deficiency of clotting factor 8 (F8, ~7 kb). I first demonstrated the successful full-length reconstitution of the large (~5 kb) and highly …
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Aspects of orthopaedic surgical research with emphasis on surgery in haemophilia and immunocompromised patients
… the output into four main clusters of which <i>Haemophilia </i>represents the largest numerically, with forty-seven contributions, and the most significant scientifically. The other three groups represent <i>Infection, including HIV and Hepatitis, Trauma and its sequelae, </i>and <i>General …
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An exploration of schooling experiences of persons living with severe haemophilia in the Western Cape, South Africa
… living with the chronic health condition, haemophilia, which is a bleeding disorder. Descriptive and Interpretive phenomenological analyses were used as theoretical, methodological, and analytical tools to explore the schooling experiences of eight adult persons living with severe …
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Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease
Haemophilia A (HA) is caused by defective synthesis of coagulation factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic …
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An investigation into the understanding of basic genetic inheritance amongst amaXhosa caregivers of patients with Haemophilia
… of patients with the genetic bleeding disorder haemophilia. Haemophilia A and B are X-linked recessive inherited, lifelong bleeding disorders that are caused by deficiencies in blood clotting factors. The condition predominantly affects males, while females are carriers and usually unaffected. …
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ΜΕΛΕΤΗ ΠΑΡΑΛΛΑΓΩΝ ΚΑΙ ΕΛΕΓΧΟΣ ΦΟΡΕΩΝ ΑΙΜΟΡΡΟΦΙΛΙΑΣ Β ΣΤΗΝ ΕΛΛΑΔΑ
THE HAEMOPHILIA B IS A SEX LINKED CONGENITAL HAEMORRAGIC DISORDER CAUSED BY REDUCED OR ABSENT SYNTHESIS OF FIX OF THE COAGULATION CASCADE. FIFTEEN FAMILIES CONSISTING OF 22 HAEMOPHILICS AND 61 RELATIVES WERE STUDIED. CARRIER DETECTION INASYMPTOMATIC FEMALE POSSIBLE CARRIERS WAS PERFORMED WITH …
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Haemophilia: a sketch of our present knowledge of the disease, with results in eight cases of the effect of normal serum on the blood coagulation time
1. The transmission of the disease in all the cases is according to the usual rule - through the female line.
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Mechanistic studies on chemical instabilities of recombinant proteins
… for treating diseases ranging from diabetes and haemophilia to various types of cancers due to their great potency and specificity. However, these macromolecules are intrinsically unstable in aqueous solutions, due to the existence of various physical and chemical degradation pathways. Degraded …
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Study of patients with suspected platelet-based bleeding disorders: a search for patients with a defect in the P2Y12 ADP receptor
… of platelet dysfunction made at UK Comprehensive Haemophilia Care Centres were investigated using platelet aggregation and secretion assays alongside controls and reference curves to nine platelet agonists to exhibit an abnormal bleeding phenotype in response to different platelet agonists, …
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Flow effect on thrombus formation in stenosed coronary arteries: a computational study
… with different thrombogenic potential, including haemophilia cases. A second sub-model for platelet aggregation on reacting surface was developed and calibrated in order to reproduce experimental data [2]. Finally, the whole coagulation model was adapted for application under flow conditions, …
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Physcomitrella patens (Hedw.) B.S.G. als Bioreaktor : Proteinzielsteuerung und Produktion von rekombinantem humanem Blutgerinnungsfaktor IX
Das Kooperationsprojekt "Physcomitrella patens als Bioreaktor zur Produktion heterologer, pharmazeutisch relevanter Proteine" hat zum Ziel, das Laubmoos als Produktionssystem zu etablieren. Vorteile des Mooses gegenüber den zumeist verwendeten Säugerzelllinien liegen vor allem in seiner …
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Physcomitrella patens (Hedw.) B.S.G. als Bioreaktor : quantitative Promotoranalyse und Produktion eines komplexen humanen Blutgerinnungsfaktors
Die vorliegende Arbeit diente der Etablierung von Physcomitrella patens (Hedw.) B.S.G. als System zur Produktion rekombinanter Proteinpharmazeutika. <br>Um ein Produktionssystem für heterologe Proteine flexibel nutzen zu können, ist es notwendig, die Expressionseffizienz der Transgene zu …