Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Haemochromatosis"”.
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Genetic and environmental modifiers of iron overload disease. Why do only some patients get serious health outcomes?
Type 1 genetic haemochromatosis causes iron overload and is most commonly caused by homozygosity for the HFE C282Y variant and to a far lesser extent other HFE C282Y and H63D genotypes. Haemochromatosis is one of the most common genetic conditions in populations of Northern European ancestry, with …
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Molecular responses of iron regulatory proteins to iron overload in human liver
… iron overload disorders, such as in hereditary haemochromatosis (HH). And although the intricate mechanisms that maintain iron homeostasis are beginning to transpire, the aetiology of this disorder remains elusive despite knowledge of the causative mutations in HFE. In an attempt to gain an …
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The effects of quercetin on iron metabolism
… potential for iron overload diseases such as haemochromatosis. By deducing the mechanisms of how dietary polyphenols interact with our intake of essential nutrients such as iron, intake can be optimised to harness the potential benefits polyphenols have to offer.
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The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway
… of iron-storage disorders such as hereditary haemochromatosis (HH) and hypotransferrinaemia (HPX), have contributed to the identification of the molecular mechanisms governing hepcidin expression. In these disorders, hepcidin expression is inappropriately low, causing increased absorption of …