Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Haematopoietic stem cell transplantation"”.
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Immunotolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for multiple sclerosis
… an autoimmune disease of the central nervous system (CNS). Autologous haematopoietic stem cell transplantation (AHSCT) has received increasing attention in recent years as a therapeutic option for treatment refractory MS. AHSCT has been proposed to induce long-term remission by initiating an …
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Role of Lymphocyte Populations Following Allogeneic Haematopoietic Stem Cell Transplantation // Роля на лимфоцитните популации след алогенна трансплантация на хемопоетични стволови клетки
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an established therapeutic approach for a range of malignant and benign haematological disorders. Despite significant advances in the field of transplantation medicine, this method remains associated with a number of complications – …
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"It really kind of like cuts my existence into two": an interpretative phenomenological analysis of the experience of adults with sickle cell disease receiving curative Haematopoietic Stem Cell Transplantation (HSCT)
Background: Sickle cell disease (SCD) is the most common single gene disorder in England. At present, Haematopoietic Stem Cell Transplantation (HSCT) is the only cure, and as of 2020, these have been funded for adults with SCD by the National Health Service (NHS) in England. Rationale: The …
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A genomic investigation into gastrointestinal antimicrobial resistance and clinical infection in patients undergoing transplantation
… cohorts of transplant recipients – Small Bowel Transplantation and Haematopoietic Stem Cell Transplantation; and 3) illustrate the longitudinal evolution of AMR in these transplant cohorts. Using genomic data, I developed high-throughput screening strategies to aid in the monitoring and …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
… is a well established alternative source of haematopoietic stem/progenitor cells (HSPC) for haematopoietic stem cell transplantation (HSCT). One factor limiting the wider use of UCB for transplantation is the relatively low cell dose from a UCB unit compared to bone marrow (BM) and peripheral …
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Evaluation of the Role of Epstein-Barr virus and Cellular Gene Expression in Paediatric and Adult Transplant Recipients
… complication after solid organ, bone-marrow and haematopoietic stem cell transplantation. While early diagnosis is known to predict encouraging outcomes, no specific markers exist for the early detection of PTLD. Epstein-Barr virus (EBV) infection is considered to be an important risk factor for …
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Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction
B cells exert antigen presenting functions at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest in the case of acute graft-versus-host …
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A retrospective description of primary immunodeficiency diseases at Red Cross War Memorial Children's Hospital, Cape Town, South Africa, 1975 – 2017
… features, and immunodeficiencies affecting cellular and humoral immunity accounted for 79% of all PIDs. The mean age (standard deviation) at diagnosis was 46 (50) months and the male to female ratio was 1.5:1. A history of parental consanguinity was present in 3 children (1.2%). Recurrent …
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A retrospective description of primary immunodeficiency diseases at Red Cross War Memorial Children's Hospital, Cape Town, South Africa, 1975 – 2017
… features, and immunodeficiencies affecting cellular and humoral immunity accounted for 79% of all PIDs. The mean age (standard deviation) at diagnosis was 46 (50) months and the male to female ratio was 1.5:1. A history of parental consanguinity was present in 3 children (1.2%). Recurrent …
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The CD4⁺ T Cell Response to Human Cytomegalovirus
… immunosuppression, such as after solid organ or haematopoietic stem cell transplantation, the virus is then able to multiply rapidly and infect numerous organ systems. Consequently, HCMV is one of the most frequently-occurring viral infections in such patients. Most of the previous studies on …
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Management of fungal infections: diagnosis and human genetic susceptibility
… impact of these diseases in the health care systems, especially when dealing with immunocompromised patients. Taking this into consideration, the development of novel diagnostic applications has been considered a critical issue in recent years. We described a multiplex PCR-based strategy …