Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Haematological malignancies"”.
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The pre-clinical evolution of haematological malignancies
… Examining the pre-clinical evolution of lymphoid malignancies using a similar study design and broader sequencing approach also revealed genetic and clinical features predictive of malignant transformation. The final part of this study investigates the prevalence of clonal haematopoiesis in …
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Effect of pomegranate extracts on apoptosis and cell cycle in haematological malignancies.
Leukaemia is a complex form of blood malignancy characterized by the uncontrolled proliferation of haematopoietic cells and progressive accumulation of these cells within the bone marrow (BM) and secondary lymphoid tissues. The exact cause of leukaemia remains unknown. Leukaemia is a major problem …
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A study of FT-IR spectroscopy for the identification and classifcation of haematological malignancies
… as a complementary clinical tool for haematological laboratory analysis. FT-IR spectra were measured from air-dried and frozen cell lines derived from lymphoma, lymphoid, myeloid leukaemia and normal and chronic lymphocytic leukaemia blood samples. Multivariate statistical analysis was …
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A mixed-methods study into the quality of life of adult survivors of haematological malignancies.
The treatments for haematological malignancies are often complex and intense and given over prolonged periods, leading to potentially debilitating symptoms and reduced quality of life (QoL). Those who survive can still experience long-term effects of both treatments and disease and often fear the …
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Generation of a novel pan-cancer chemokine receptor-modified CAR-T cell therapy directed towards nfP2X7
… significant success in the treatment of multiple haematological malignancies. However, solid cancers present challenges such as tumour antigen heterogeneity and complex mechanisms of immune evasion that have limited the translation of CAR-T cell therapies from haematological malignancies to solid …
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Genomic Discovery of recurrent CD44-SLC1A2 Gene Fusion in Gastric Cancer
… targets. While fusion genes are well-known in haematological malignancies, our knowledge of recurrent fusion events in solid epithelial tumors is far less mature. In this study, we aimed to identify genes affected by genome rearrangements in gastric cancer (GC), which is the second highest …
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Investigating the metabolic impact of Metformin and Berberine in combination with Venetoclax for Acute Myeloid Leukaemia treatment
… (AML) stands as a significant challenge in haematological malignancies, particularly due to poor outcomes in older patients and resistance to therapy. BCL-2, an anti-apoptotic protein, is overexpressed in AML. The BCL-2 antagonist Venetoclax inhibits OXPHOS and induces apoptosis in AML …
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Mechanisms driving the expansion and progression of splicing factor-mutant clonal haematopoiesis
… is associated with an increased risk of incident haematological malignancy and several non-haematological conditions. Mutations in splicing factor genes (namely SF3B1, SRSF2, and U2AF1) are frequent drivers of CH, particularly in the elderly, and confer a high risk of progression to haematological …
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Functional Investigation of Dual αvβ3 and αllbβ3 Integrin Inhibition in Haematological and Solid Tumour Models
… cause of increased mortality. In addition, haematological malignancies (leukaemia and lymphoma) are a significant cause of morbidity and mortality in both children and adults. Therefore, new treatments which will inhibit cancer progression are required. Integrin adhesion receptors, …
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Understanding the role of extrinsic regulators in normal and malignant haematopoiesis
… their role in driving the evolution of clonal haematological malignancies. First, I explored the impact of extrinsic regulators on highly purified single HSCs and found that minimising cytokine signalling could sustain a hibernation state in HSCs with the retention of functional properties both …
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Translational regulation in aggressive B-cell lymphomas
… stage of B-cell development are the most common haematological malignancies with heterogeneous molecular mechanisms and clinical presentation. Although the last decade witnessed considerable advances in the biology of GC reaction and related tumours, the studies focused predominantly on the …
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Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
… the way for successful treatment of those with haematological malignancies and other blood disorders. In addition, the year 2013 marked the 25th anniversary of the first UCB transplant that took place in France in October 1988. Since then over 600,000 UCB units have been banked and more than …
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Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease
… (Dex), has been used to treat several haematological malignancies including ALL. To understand better how GC-resistant leukemic cells respond to Dex treatment, combination treatment of Dexamethasone with Chloroquine (CLQ), Thapsigargin (TG), Rotenone (ROT) and Bortezomib (BTZ) were used …
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Elucidating oncogenic mechanisms in human B cell malignancies
… consists of two pieces of work investigating haematological malignancies; Acute Lymphoblastic Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric malignancy and despite increasingly improved outcomes for patients, ~ 20% of all …
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Fusion genes in breast cancer
… are a common and important feature in haematological malignancies, but have until recently been seen as unimportant in epithelial cancers. The discovery of recurrent fusion genes in prostate and lung cancer suggests that fusion genes may play an important role in epithelial …
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"It really kind of like cuts my existence into two": an interpretative phenomenological analysis of the experience of adults with sickle cell disease receiving curative Haematopoietic Stem Cell Transplantation (HSCT)
… Most research into HSCT have been in relation to haematological malignancies. I reasoned that further research adopting an explicitly psychological focus would be valuable in understanding the lived experiences of HSCT recipients with SCD and how they can be supported psychologically through this …
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The structure and evolution of breast cancer genomes
Chromosome changes in the haematological malignancies, lymphomas and sarcomas are known to be important events in the evolution of these tumours as they can, for example, form fusion oncogenes or disrupt tumour suppressor genes. The recently described recurrent fusion genes in prostate and lung …
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