Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"HVR1"”.
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Short interval change in hepatitis C hypervariable region 1 in chronic infection. Are there treatment windows in the envelope?
… rates) and one of these, Hypervariable region 1 (HVR1) has been recognised as a major target of the adaptive immune response. HVR1 quasispecies complexity and diversity have been implicated as predictive of response to dual therapy. Little, however, is known about the natural history of these …
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The Structural Basis of Flaviviridae Interaction with Antibodies and Receptors
… enhanced by deletion of hypervariable region 1: HVR1) of E2 and modulated by the genotype from which sE2 was generated. Furthermore, neutralization of HVR1-deleted HCV by a cross-reactive antibody was enhanced in a genotype-specific manner that correlated with sE2:CD81-LEL affinity measurements. …
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Candidate Bivalent HCV Vaccine: A Novel Approach To Vaccine Design for Hyper-variable Viruses
… HCV vaccine explicitly designed to elicit AB to HVR1 (hypervariable region 1), the most variable epitope of any known human pathogen. Remarkably, the polyclonal response induced by vaccination was pan-genotypically neutralizing. These results support our hypothesis that physiochemically …
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Population genetic history of the British roe deer (Capreolus capreolus) and its implications for diversity and fitness
… Using a 419 bp region of the mt-DNA d-loop (HVR1) amplified from ancient and modern UK samples a direct comparison was made with previously published European data. Results showed that UK populations belong to the central lineage, indicating a post glacial re-colonisation that is likely to …
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Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin
… rate, which is especially pronounced in the HVR1 of the N-amino terminal region of E2. Genotypes, subtypes and quasispecies can be distinguished. Quasispecies refer to the genetic diversity of a virus population that can be observed in a single infected individual with individual viral …