Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"HUMORAL IMMUNE RESPONSE"”.
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Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies
… numerous studies have examined T cell-mediated immune responses to melanoma and their therapeutic potential, there has been less focus on B cell-mediated immune responses and the tumor-reactive antibodies they produce. The aim of this work was three-fold: (1) to develop a methodology to detect …
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REDOX REGULATION OF B CELL ACTIVATION AND THE ANTI-VIRAL HUMORAL IMMUNE RESPONSE
… of the role of these molecules during the humoral immune response, the oxidation events that modulate B cell signaling, and their contribution to B cell activation is limited. Therefore, we have examined the importance of the reversible formation of cysteine sulfenic acid on B cell …
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Characterizing Compensatory Effects of Silymarin on Gossypol Toxicosis in Lines of Chickens Divergently Selected for Humoral Immune Response
… was to determine if divergent selection for humoral immune response would have an impact on the ability of the chicken to cope with gossypol toxicosis. Two preliminary studies were conducted. One determined basal activities of liver detoxification enzymes at various ages. The other determined …
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The Humoral Immune Response of Elks (Cervus elaphus nelsoni) and Mice to Vaccination with Brucella abortus Strain RB51
… an O-chain and thus a lack of an anti-O-chain humoral response greatly simplifies identification of vaccinated versus field strain infected animals. The three primary objectives of this research were the following: 1) to develop a serological assay to detect anti-RB51 antibodies in vaccinated …
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A B-cell or a key player?: The role of the humoral immune response in melanoma, highlighting the importance of method development
Investigations of the humoral immune response to melanoma have revealed that B-cells and antibodies can play both pro and anti-tumourigenic functions. B-cells can infiltrate melanomas and become organised into a tertiary lymphoid structure; their presence have been associated with better …
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Development of protein microarrays for the investigation of host-pathogen interactions
… The work presented here investigates the humoral immune response to VZV infection in more detail, to better understand the mechanisms of the adaptive immune response to lead to improved diagnostic tests and vaccine development.
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ΧΗΜΙΚΗ ΑΝΟΣΙΑ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΕΝΕΡΓΟ ΗΠΑΤΙΤΙΔΑ ΣΕ ΣΧΕΣΗ ΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΤΟΥ HBSAG
… IN THE PATHOGENESIS OF THE DISEASE. THE HUMORAL IMMUNE RESPONSE OF PATIENTS, WITH BIOPSY PROVED, CAH WAS STUDIED, BOTH IN THE HBSAG POSITIVE (40 PATIENTS) AND IN THE HBSAG NEGATIVE (24 PATIENTS) GROUP. SERUM IMMUNOGLOBULINS, VIRAL ANTIBODIES TO RUBELLA, MEASLES AND CYTOMEGALOVIRUS (CMV) …
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Virus tropism and neutralization response in SIV infection
… have studied virus tropism and evolution of the humoral immune response in relation to pathogenesis in cynomolgus macaques experimentally infected with SIVsm (of sooty mangabey origin) by intravenous (IV) or intrarectal (IR) route. Route of transmission did not influence disease progression or …
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The Role of Humoral Immunity in The Resolution of Rotavirus Infection in Mice
The immune response to rotaviruses has been studied extensively in several animal species. However, the importance of a humoral immune response in the resolution of active rotavirus infection has not been investigated directly. Most animals became resistant to rotavirus-induced diarrhea after a …
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Study of the Immune Correlates of Protection in Rhesus Macaques Vaccinated against Simian Immunodeficiency Virus
… I aimed to describe at the molecular level the immune mechanisms of protection in a rhesus macaque (Macaca mulatta) vaccinated in an RV144-like schedule and protected from Simian Immunodeficiency Virus (SIV) infection, with a particular focus on the humoral immune response of the animal. More …
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Evaluation of two SARS-CoV-2 immunoassays
… to assess sensitivity. Additionally, postvaccine humoral response and other parameters was assessed in a cohort of laboratory staff. Results: For the anti-nucleocapsid antibody assay, specificity was 99.7% based on 316 samples and sensitivity 91.3% based on 404 samples. For the anti-spike antibody …
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Adenovirus Vectors as Potent Adjuvants in Vaccine Development
<p>Due to their ability to activate the immune system, replication-defective Adenoviruses (Ad) are potential vaccine vectors for several pathogens. The proinflammatory response to Ad contributes to the response to vaccine antigens. We found that reactive oxygen species (ROS) are an important signal …
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The effects of feeding aflatoxin contaminated swine diets with clays on performance, mineral metabolism, immune response and liver function in weanling and growing Pigs
… liver function, mineral metabolism and humoral immune response. In the nursery phase of Study I, weanling pigs (n=96) were fed 1% sodium bentonite (SB) with and without AC (922 ppb). In the grower phase, 48 pigs from the nursery phase were continued on SB treatments for 5 wk; AC was …
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Molecular and functional analysis of the tumour antigen T21
… tumour cells by stimulating the body’s adaptive immune system. To achieve this objective, it is important to identify and study antigens that are distinctively expressed in cancer and can be used effectively to initiate or enhance immune responses. T21 (Testis clone 21) was identified as a member …
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The immune-modulating activity of Sutherlandia frutescens
… of Sutherlandia frutescens on the inflammatory response and T cell differentiation in vitro using cytokines as biomarkers. Whole blood cells containing various concentrations of Sutherlandia frutescens were stimulated in vitro with either Lipopolysaccharide (LPS) or Phytohaemagglutinin (PHA). …
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The relationship between humoral and local anti-sperm antibody production and infertility in turkey breeder hens
… to determine the role of the turkey hen’s immune system in the so-called seasonal decline in fertility. Results from Experiment I demonstrated that trauma to the oviduct induced either at the time of the initial artificial insemination, or during subsequent inseminations had no effect upon …
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Investigation of Ring Finger Protein 8 in Mammalian Physiology and Pathogenesis
… cells have evolved a sophisticated DNA damage response (DDR) network that senses the physical existence of DNA DSBs, followed by signal propagation to repair these genetic lesions. Interestingly, DSBs are not only hazardous, but are also programmed to occur during normal physiological processes …
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An investigation of the natural history of early cervical human papillomavirus infection and its relationship to the acquisition of epithelial abnormalities of the cervix
… and its use in defining the kinetics of the humoral immune response to cervical HPV16 and HPV18 infections; and the analysis of measurements of the viral load of HPV16 and HPV18, and their association with epithelial abnormalities of the cervix
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Modification of a DNA Vaccine for Oral Administration in Fish for Aquaculture by Using Non-Microbial Nanoparticles
… chitosan or polylactide-co-glycolide (PLG). The immune response of hybrid striped bass (Morone saxatilis x Morone chrysops) following oral delivery of a DNA vaccine containing Mycobacterium marinum Ag85A plasmid in either chitosan or PLG nanoparticle encapsulation was evaluated. Hybrid striped …
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