Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"HTRF"”.
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Biased Constitutive Activity in the Uveal Melanoma Oncogene CYSLTR2 is Unique in CYSLTR2 Germline and Pan-Cancer Human Variome
… using a homogenous time resolved fluorescence (HTRF) IP1 accumulation assay, we show that CysLTR2-L129Q is a constitutively active mutant that strongly drives Gq/11 signaling pathways. However, CysLTR2-L129Q only poorly recruits β-arrestin as shown by a bioluminescence resonance energy transfer …
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… domains of IRAKs and developed a high-throughput HTRF assay for the identification of protein-protein interaction inhibitors to disrupt this interaction. Together, this work lays the foundation to explore the IRAK pseudokinases as potential drug targets for the treatment of innate immune diseases …
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Microfluidic Approaches for Investigating Aggregated Forms of Disease-Related Proteins
The self-assembly of soluble proteins is a common phenomenon observed in nature. It ranges from the formation of functional biomaterials, such as actin filaments and tubulin microtubules that form the cytoeskeleton, to the abnormal deposition of aberrant aggregates that lead to disease. There are …