Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"HTR2C"”.
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Influence of serotonin-related genes on behavior and body weight
… the gene encoding the serotonin receptor 5-HT2C (HTR2C) was associated with weight loss in teenage girls. 2) Supporting the above-mentioned finding, the Cys23Ser substitution in the HTR2C was associated with low body weight also in a middle-aged female cohort recruited from the general population; …
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Deep Molecular Characterization of Human Cortical Cell-Types
… and reproducible methodology revealed that an HTR2C expressing layer 5a excitatory neuron population is selectively vulnerable and drastically diminished across all stages of Huntington's disease. In collaborative studies, in which we used samples from an AAV2.retro, striatal injected nonhuman …
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Automated, highly scalable RNA-seq analysis
… show that upregulation of the serotonin receptor Htr2c causes aberrant calcium spiking in the Tsc1 knockout mouse, and implicate it as a novel therapeutic target for tuberous sclerosis. The third chapter of this work investigates transcriptome regulation in the superior colliculus with prolonged …
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METABOLIC ADVERSE EFFECTS INDUCED BY SECOND GENERATION ANTIPSYCHOTIC DRUGS IN PEDIATRIC PATIENTS: PHARMACOGENETIC PROFILING AND MECHANISTIC ANALYSIS OF GENETIC VARIANTS EFFECT IN VITRO MODELS
… rs5181147 in 5- Hydroxytryptamine Receptor 2C (HTR2C), rs1799732, rs6275, rs7131056 in D2 dopamine receptor (DRD2) and rs489693 in melanocortin-4-receptor (MCR4). We consider that the identification of these SNPs might provide useful input for personalized and individualized early intervention. …
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Pharmacological targets for treatment of retinal neurodegenerations: new perspectives [Nuove prospettive sui target farmacologici per il trattamento della neurodegenerazione retinica]
… metabotropici serotoninergici HTR5A, HTR1D, HTR2C e l’adenosinico ADORA2B, hanno mostrato un elevato potenziale di novità come target per il trattamento del glaucoma. Inoltre, i recettori purinergici ionotropici P2X3 e P2X4, insieme agli enzimi codificati da CYP2C8, LDHA e MAOB potrebbero …