Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"HTR"”.
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Physics-Based 3D Multi-Directional Reloading Algorithm for Deep Burn HTR Prismatic Block Systems
… deep burn very high temperature reactors (DB-VHTRs) was developed and tested to meet DB-VHTR operation constraints utilizing a high fidelity neutronics model developed for this dissertation. The high fidelity automated neutronics model allows design flexibility and metric tracking in spatial …
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INTERROGATING THE ROLE OF N6-METHYLADENOSINE RNA MODIFICATION ON TELOMERASE BIOLOGY
… The RNA subunit of telomerase, TERC, hTR acts as a template for its reverse transcriptase activity and as a scaffold for the binding of proteins involved in the maturation, stabilization, and trafficking of the telomerase holoenzyme. Mutations or inefficient processing of hTR leads to …
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Understanding the Relationship Between Health Technology Reassessment and Knowledge Translation
… be applicable to Health Technology Reassessment (HTR). This thesis reports on three studies to determine how KT approaches are used to translate HTR outputs to achieve the desired outcomes. The first study was a scoping review of full-spectrum (phases of planning/design, evaluation, …
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Impact of nuclear data libraries for criticality calculation of HTGR
… Temperature engineering Test Reactor (HTTR) and HTR-10 reactor models. Serpent 2 was used to calculate criticality and its uncertainty due to nuclear data, using data from evaluated nuclear data libraries ENDF/B-VIII.1 and JENDL-5. Uncertainty quantification demonstrates that for both HTTR and …
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The influence of channel-skewed bedforms on flow structure in a high-amplitude meandering channel
… changes, known as the hydraulic transition zone (HTR), was redefined to include both the interaction of curvature-induced secondary flow cells as well as the normalized strength of secondary flow. The inclusion of secondary flow strength in the definition of the HTR demonstrates that the HTR …
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The role of Thyroid hormone Transporters Monocarboxylate Transporter 10 (MCT10) and Monocarboxylate Transporter 8 (MCT8) in extravillous trophoblasts.
… extravillous trophoblasts (EVTs). Aims: Using HTR-8/SVneo cells as a model of 1st trimester EVTs, we assessed 1) Triiodothyronine (T3) effects on gene expression and cell proliferation; 2) the effect of altered MCT8 or MCT10 expression on proliferation and apoptosis; and whether effects were …
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Repression of telomerase components in isogenic normal, immortal and tumorigenic cells
… reverse transcriptase, hTERT, an RNA component (hTR) that has a template region for reverse transcription and the RNA binding and modifying protein, dyskerin. There is evidence indicating that these components may contribute to the survival and/or proliferation of tumour cells via mechanisms that …
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DESIGN, THERMAL SIMULATION AND ECONOMIC FEASIBILITY ANALYSIS OF A PLANT FACTORY HOUSED IN A UNDERGROUND MINE DRIFT
… and 298 K will results in heat transfer rate (HTR) increasing by 26.7% and decreasing by 62.5% as compared to the base case (284 K), respectively, indoor air temperature from 293/287 K to 303/297 K (light/dark) will result in 80.8% increasing of HTR, and rock thermal conductivity 1.5 and 3.5 …
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Understanding the barriers to, and impact of, men's engagement in physical activity and health related behaviours : an examination of an English Premier League football in the community men's health programme
… the distinct barriers that hard-to-reach (HTR) male populations encounter when attempting to commit to regular participation in physical activity and health behaviours and to examine the impact of engaging in a 12 week FitC intervention. Economic, environmental and social barriers to …
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Biochemical and structural studies of human telomerase regulation
… which are tethered together by telomerase RNA (hTR) (Nguyen et al., 2018). The H/ACA RNP lobe is essential for telomerase biogenesis and hTR accumulation, and it harbours many disease mutation residues (Egan and Collins, 2010, 2012b; Ghanim et al., 2021; Nguyen et al., 2018). H/ACA RNPs also …
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MCNP4B modeling of pebble-bed reactors
… of critical experiments carried out at the HTR-PROTIEUS and ASTRA facilities, and the critical loading of the HTR-10 reactor. A body-centred cubic lattice of spheres with a specified packing fraction approximates the pebble bed, and exclusion zones offset the contribution of partial spheres …
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Telomerase Inhibition and Sensitization of Breast Tumor Cells
… enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an …
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
… transcriptase (hTERT) and an RNA template (hTR or hTERC). The RNA template is used by the reverse transcriptase to add the TTAGGG hexameric repeats to elongate telomeres and compensate for the loss of telomeres each cell division caused by the end replication problem. Imetelstat is an …
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Entry-based Planning of Neurosurgical Trajectories
… There was no significant difference in hit rate (HtR) between hydrocephalus and trauma patients for the region of high accuracy and the region of high dispersion (p = 0.49, 0.32). There also was no significant difference in catheter length between hydrocephalus and trauma patients for the region …
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Telomerase : a tumor marker in the peripheral blood of colorectal cancer patients
… of two components; one is the functional RNA (hTR), which acts as a template for telomeric DNA synthesis. The second component is human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, which is concomitantly associated with telomerase activation during …
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Andstæð hlutverk TGF-ß fjölskyldunnar í fylgjumyndun og meðgöngueitrun
… Í rannsókninni var notuð næriþekjufrumulínan HTR-8/SVneo og HUVEC frumur. Western blot og mótefnalitun var notuð til að meta próteintjáningu in vitro. Sáraviðgerðarpróf var notað til að meta frumuskrið. Mótefnalitun fylgjuvefjasýna og ELISA próf á blóðsýnum voru notuð til að athuga …
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Hydrodynamics and Morphodynamics in Kinoshita Meandering Channels
… flow. The Hydraulic Transitional Region (HTR) is used to describe the development of the three-dimensional flow structure along meandering channels. The upstream-skewed condition produces a shear layer with high turbulence intensity around the bend apex, while the downstream-skewed …
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Blood Donor Genotyping
… of adverse haemolytic transfusion reaction’s (HTR), approximately 3% of recipients become sensitised following an immune reaction to a non-self blood group antigen after a single transfusion episode. This proportion can rise dramatically in patients requiring frequent transfusion support, with …
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Application of physicochemical and biological pretreatments to enhance volatile fatty acids production via Dark Fermentation from agri-food waste
… (MW) and Hydrothermal Reactor (HTR) pretreatments (Article 2) to quantify the recovery of Total Reducing Sugars (TRS), proteins (PR), and VFAs. MW pretreatment emerged as the most energy-efficient technique for rapidly solubilizing accessible biomasses such as OP and SBP. …
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The Effect of Coating Parameters On Advanced TRISO Fuels With Zirconium Carbide
… in the very high temperature reactor (VHTR) design. These problems include but are not limited to over pressurization of the kernel due to fission gas buildup as well as kernel migration, in the presence of a temperature gradient, known as the amoeba effect. To negate these problems a …
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