Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"HTLV-1"”.
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HTLV-1 bZIP FACTOR ACTIVATES MYOFERLIN EXPRESSION TO FACILITATE HTLV-1 INFECTION AND MIGRATION OF INFECTED T-CELLS
Human T-cell Leukemia Virus type 1 (HTLV-1) is a complex retrovirus responsible for diseases such as Adult T-cell Leukemia (ATL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The viral protein HBZ is consistently expressed in infected individuals and plays a crucial role …
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Study of the DNA Damage Complexes Within the HTLV-1 Tax Oncoprotein Interactome
<p>Human T-cell leukemia virus type 1 (HTLV-1) is a transforming retrovirus that can give rise to adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Tax is a virally encoded oncoprotein that is involved in HTLV-1 mediated cellular transformation. It …
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Mutational analysis of the human histone chaperone, Nap1, in nucleosome disassembly at the HTLV-1 promoter
… uses human T-cell leukemia virus, type 1 (HTLV-1) as a model for studying eukaryotic transcription activation and gene regulation. Previous studies using chromatin immunoprecipitation to look at the HTLV-1 promoter have correlated transcription activation with a decrease in …
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Die Spezifität der systemischen und intrathekalen Immunantwort bei der Infektion mit dem humanen T-lymphotropen Virus 1 (HTLV-1)
Das Retrovirus HTLV-1 induziert eine Myelitis, die HTLV-1 assoziierte Myelopathie / tropische spastische Paraparese (HAM/TSP) genannt wird. Bei dieser chronisch entzündlichen Erkrankung des ZNS infiltrieren HTLV-1 infizierte CD4+ T-Lymphozyten das Rückenmark und exprimieren retrovirale Proteine. …
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Darifenacina versus Estimulação Elétrica Transcutânea Parasacral para Tratamento da Síndrome da Bexiga Hiperativa Neurogênica em Individuos Infectados pelo HTLV-1
… approximately 78% of individuals infected with HTLV-1 with associated myelopathy and in 59% of infected individuals without motor impairment. Anticholinergic medications are widely used to treat OAB symptoms, but the frequency of adverse events such as constipation, dry mouth, visual and mental …
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Deephtlv: A Deep Learning Framework For Detecting Human T-Lymphotrophic Virus 1 Integration Sites
… called human T-lymphotrophic virus type 1 (HTLV-1). Since then, HTLV-1 has been identified as the causative agent behind several diseases such as adult T-cell leukemia/lymphoma (ATL) and a HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP). As part of its normal …
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Regulation of Human T-cell Leukemia Virus Type 1 Infection and Replication
… Currently, there is no known receptor for HTLV-1, though a number of factors that enhance entry have been identified. In an effort to identify a cellular receptor or attachment factor for HTLV-1, we carried out a retroviral cDNA library screen, in which cDNA from permissive HeLa S3 cells …
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Characterization of Human T-Cell Leukemia Virus 1 Reverse Transcriptase
<p>Human T-cell leukemia virus 1 (HTLV-1) is a type C human retrovirus which has been the causative agent of Adult T-cell leukemia. Replication of the retrovirus; requires a reverse transcriptase which converts the retroviral RNA into DNA which is later incorporated into the host's genome. Very …
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Isolation and Functional Mapping of Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein DNA-Damage Complexes
<p>Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus which causes Adult T-cell Leukemia (ATL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Cellular transformation can be caused by a single viral <em>trans</em>-activating protein, Tax. Tax may …
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Studying viral-like particles using fluorescence fluctuation spectroscopy
… extension of FFS to study the human retrovirus HTLV-1 will be covered. Studying HTLV-1 and comparing the results to our studies of HIV-1 provides hints about which features are common among retroviruses and which features are virus specific. In previous FFS studies of VLPs, we focused on a …
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Quantitative Fluorescence Studies in Living Cells: Extending Fluorescence Fluctuation Spectroscopy to Peripheral Membrane Proteins
… insight into the early assembly steps of the HTLV-1 retrovirus.
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Subcellular Localization of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
<p>Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus that gives rise to Adult T-cell Leukemia (ATL) and a variety of other subneoplastic conditions such as HTLV-Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP). In ATL, the transformation and immortalization of …
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New Targets of p53 Regulation: From Aging to Immune Response
… high degree of homology with the exogenous virus HTLV-1. I observe the upregulation of human endogenous retroviral envelopes in response to p53 activation. I hypothesize that the expression of endogenous retroviruses may serve as a marker of oncogenic stress in prostate cancer with diagnostic …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… virus, are clinically similar to HIV-1 and HTLV-1 (human T-lymphotrophic virus), respectively. Like gpl20 of HIV-1, the envelope glycoprotein of FeLV produces lymphocytic and neuronal toxicity. In the first study of this dissertation, we hypothesized that retroviral envelope glycoproteins …
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Die Rolle des C-Terminus von Env in der HIV-1-Infektion und -Replikation
… Phänotyp wahrscheinlich nicht auf deren HTLV-1-Tax-Expression beruht und auch nicht durch Expression des Env-CTs in trans in nicht-permissiven H9-Zellen induziert werden kann. Im Fall der Mutante pNL-Tr752 konnte ein einziger Aminosäureaustausch den durch die Trunkation des Env-CTs …