Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"HSV-2"”.
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Clinical Implications of HIV-1, HSV-2 Co-infection and Opportunities for Intervention
HSV-2 may have adverse consequences in HIV. I evaluated the impact of HSV-2 co-infection on (highly active antiretroviral therapy)-untreated HIV infection in a systematic review of observational studies (study 1) and a retrospective cohort (study 2). I further evaluated whether HSV reactivation …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
In order to develop an effective vaccine for HSV-2 it is important to adequately understand the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available for this animal are limited. Consequently, many reagents and assays used …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
In order to develop an effective vaccine for HSV-2 it is important to adequately understand the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available for this animal are limited. Consequently, many reagents and assays used …
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A Role for the HSV Tegument Protein pUL16 in Modulating Cellular Energy Metabolism during HSV-2 Infection
… several processes during Herpes simplex virus (HSV) infection, including virion morphogenesis and cell-to-cell spread of infection. Recent literature has also demonstrated that HSV-1 pUL16 localizes to distinct regions of mitochondria. Consistent with these findings, our proximity-dependent …
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Investigating synergy: Mathematical models for the coupled dynamics of HIV and HSV-2 and other endemic diseases
… investigate synergy: synergy between HIV and HSV-2 or between humans and mosquitoes in a malaria study. Each of the three coupled disease models addresses different epidemiological questions with regard to gender or disease structure in the context of sexually-transmitted diseases (STDs), …
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ANALYSIS OF HERPES SIMPLEX VIRUS ICP0 FUNCTION AND THE ANTIBODY RESPONSE TO A LIVE HSV-2 ICP0- MUTANT VACCINE
<p>Both herpes simplex virus type-1 (HSV-1) and herpes simplex virus type-2 (HSV-2) are human pathogens that are capable of causing significant disease. More than 600 million people are infected with HSV-2 genital herpes and every day >40,000 new HSV-2 infections are transmitted to naïve …
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Co-occurrence of shedding Herpes Simplex Virus type-2 (HSV-2), Human Papilloma Virus (HPV) and Human Immunodeficiency Virus 1 (HIV-1) in the female genital tract among HIV-infected women
… Most of the participants showed pre-exposure to HSV-2, but shedding of HSV-2 was substantially less common. HPV was detected in 72% of the participants, with no significant difference by ART status. Overall, 70.3% of samples had at least one viral pathogen detected - 60.4% among ART-Using women …
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Induction of the <em>Chlamydia trachomatis</em> Persistent State by Herpes simplex Virus Type 2 Does Not Require Productive Viral Replication.
… studies have shown that multiple infection with HSV-2 and <em>Chlamydia trachomatis</em> occurs <em>in vivo</em>. We hypothesize that (i) HSV-2 co-infection of <em>C. trachomatis</em> infected cervical epithelial cells induces chlamydial persistence; (ii) productive HSV-2 replication is required …
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Evaluation of immunomodulatory compounds for identification of an anti-herpetic innate immune response profile
Herpes simplex virus type 2 (HSV-2) is a prevalent world-wide sexually transmitted infection (STI) that commonly infects the genital mucosa and establishes a life-long latent infection. The virus periodically reactivates producing recurrent shedding episodes that increase the risk of acquiring …
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The role of autonomic neurons in the pathegenesis of herpes simplex virus infection
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are major human pathogens. HSV establishes latency in the nervous system and reactivates to cause recurrent disease, resulting in transmission of progeny virions to naïve individuals. Though HSV-1 and HSV-2 share similar structure and genes, they …
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Characterizing the Role of the Herpes Simplex Virus Type 2 UL21 Protein in Viral Nuclear Egress
The herpes simplex virus type 2 (HSV-2) is an important human pathogen that is the main cause of genital herpes infections and has a significant and wide-ranging impact on human health. HSV-2 infections are one of the most common sexually transmitted diseases and are highly prevalent worldwide, …
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Stress hormones epinephrine and corticosterone modulate herpes simplex virus 1 and 2 productive infection and reactivation primarily in sympathetic, not sensory, neurons
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with exacerbation of clinical symptoms and induction of recurrences in humans and …
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
… intravaginal herpes simplex virus type II (HSV-2) infection. Increased HSV-2 pathology with prior helminth exposure was associated with diminished innate anti-viral immunity, increased IL-33, ILC2 and IL-5 responses, as well as significant eosinophilia. Interestingly, abolition of canonical …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… infection strategy of herpes simplex virus (HSV) consists of an initial primary lytic infection in epithelial cells, followed by establishment of lifelong latency in sensory and autonomic neurons of the peripheral nervous system that innervate the site of infection. Any cellular stress …
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The Isolation and Characterization of Growth Regulatory Factors Produced by a Herpes Simplex Virus Type 2 Transformed Mouse Tumor Cell Line, H238
… of cells with herpes simplex virus Type 2 (HSV- 2)occurs by an unknown mechanism. No specific gene or gene product has been consistently associated with HSV-2 transformation as is the case for other tumor viruses. This study was performed in an attempt to associate HSV-2-transformation with …
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Modified Green Tea Polyphenol, Palmitoyl-EGCG and Black Tea Theaflavins: Promising Natural Herpes Simplex Virus 1 and 2 Agents
… to possess antiviral properties, including anti-HSV (Herpes Simplex Virus). There is no cure for the diseases caused by HSV infections. While there is a rising concern over the increase in resistant HSV strains, new effective agents for prevention are in critical need to be developed. Green tea’s …
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Estradiol and MDMA affect the susceptibility and immune response to genital herpes and genital herpes immunization
Herpes simplex virus type 2 (HSV-2), the most frequent cause of ulcerative genital herpes disease, has infected nearly one-in-five Americans and is even more prevalent in the developing world. The virus is also known to be a synergistic copathogen to HIV and may even facilitate its infection. …
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ΑΝΤΙΓΟΝΙΚΗ ΜΕΛΕΤΗ. ΤΥΠΟΠΟΙΗΣΗ ΚΑΙ ΑΝΟΣΟΕΝΖΥΜΑΤΙΚΟΣ ΕΛΕΓΧΟΣ ΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΤΩΝ ΤΥΠΩΝ 1 ΚΑΙ 2 ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ (HSV)
STUDY ON THE ANTIGEN PRODUCTION OF HSV-1/733 AND HSV-2/734 FROM INFECTED CELL CULTURES, THE PRODUCTION OF MONOSPECIFIC ANTISERA, THE DETECTION AND ISOLATION OF SPECIFIC ANTIGENS FOR THE TWO TYPES OF VIRUS. TYPING OF 40 ISOLATES FROM DIFFERENT HERPETIC LESIONS OF PATIENTS. THE TYPING OF THESE …
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