Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"HSV-1"”.
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The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
Herpes simplex virus type 1 (HSV-1) is a globally prevalent neurotropic virus that establishes lifelong latency within trigeminal ganglionic neurons and undergoes periodic reactivation, resulting in recurrent mucocutaneous and ocular disease. In severe manifestations, HSV-1 infection can progress …
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Investigating HSV-1 pUL56 mediated antagonisation of DNA sensing mechanisms
Herpes Simplex Virus 1 (HSV-1) is a large, enveloped DNA virus that infects around two-thirds of the world population. HSV-1 is known to successfully remodel the host cell microenvironment to allow for efficient replication and propagation of progeny virions. One of the ways in which HSV-1 achieves …
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Effect of Chinese Knotweed Extract on HSV-1 Infection of Vero Cells
<p>HSV-1 is an opportunistic virus responsible for infecting the majority of the global population. The ability of this virus to strategically alternate between lytic and latent states has made the development of effective treatments challenging. Polygonum multiflorum (Chinese Knotweed, CK) is a …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
Herpes Simplex Virus (HSV) – 1 also known as Human Herpes Virus (HHV) – 1 is a common infectious agent of humans which can cause a wide variety of clinical outcomes, ranging from mild mucocutaneous lesions to long term morbidity and possible mortality. Viral entry into cells requires the …
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Investigating the structure and function of HSV-1 tegument proteins: UL7 and UL51
Herpes simplex virus-1 (HSV-1) has a large double-stranded DNA genome encased within an icosahedral capsid. The capsid is surrounded by a protein-rich layer, termed tegument, and a membranous envelope containing viral glycoproteins. HSV-1 genome replication and encapsidation occurs in the nucleus, …
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Relating the structure of the HSV-1 UL25 DNA packaging protein to its function
The herpes simplex virus type 1 (HSV-1) UL25 protein (pUL25) is a minor capsid protein that is essential for packaging the full-length viral genome into preformed precursor capsid. It is also important in virus entry and recently has been implicated in the egress of the virus from the cell (Coller …
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Studies on the interaction of HSV-1 multifunctional protein ICP27 with the nuclear pore complex proteins
Herpes simplex virus (HSV-1) ICP27 is a multifunctional immediate early (IE) protein, required for expression of several early and late genes and acts at transcriptional and posttranscriptional levels. ICP27 contains both a nuclear localization signal and a nuclear export signal and shuttles …
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The role of gylcoprotein K (gK) in the ocular and neuropathogenesis of herpes simplex virus-type 1 (HSV-1)
<p>Herpes simplex virus type 1 (HSV-1) is a DNA virus that is a ubiquitous pathogen of humans. The hallmark of the HSV-lifecycle is infection of a mucosal surface with spread to sensory neurons where the virus establishes a latent infection with periodic recurrences for the life of the host. The …
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An exploration of the interplay between HSV-1 and the non-homologous end joining proteins PAXX and DNA-PKcs
… the interplay between herpes simplex virus 1 (HSV-1), a dsDNA virus, and two NHEJ proteins, DNA protein kinase catalytic subunit (DNA-PKcs) and paralogue of XRCC4 and XLF (PAXX). PAXX was first described in the literature as a NHEJ protein in 2015, but whether it has any role in the regulation …
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Vergleichende Analyse herpesviraler Amplicon-Vektoren am Beispiel von Antigenen des Humanen Papillomvirus-16
… Kandidaten für den Einsatz in der Gentherapie. HSV-1 Amplicon-Vektoren bestehen aus einem Amplicon-Plasmid, welches in die HSV-1 Virushülle verpackt ist. Das Amplicon-Plasmid ist Träger des jeweiligen Transgens. Zur Verpackung der Amplicon-Plasmide wurden zwei virale Helfersysteme, nämlich (i) …
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Immunevasion von Herpes-simplex-Virus Typ 1: Angriff auf Zellen des Immunsystems
… darin, neue Mechanismen zu identifizieren, wie HSV-1 die Immunantwort durch Interaktion mit Zellen des Immunsystems unterdrücken kann. Es konnte kein verändertes Proliferationsverhalten von Lymphozyten in Anwesenheit von VP22 beobachtet werden. Wie die vielfältigen Interaktionen dieses viralen …
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Purification of glycoproteins from herpes simplex virus
… glycoproteins from herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) for diagnostic use. The most likely candidate for a type-specific glycoprotein of HSV-1 is glycoprotein C (gC), although it has recently been shown to contain some type-common antigenic determinants. HSV-1 and HSV-2 were …
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Multi-modal imaging of herpesvirus infection
Herpes simplex virus (HSV)-1 is a large, enveloped DNA virus that undergoes a complex assembly pathway in the cell. Capsids assemble in the nucleus, cross the nuclear envelope into the cytoplasm by budding and fusion through the nuclear membranes, and acquire a proteinaceous ‘tegument’ layer in the …
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Glycoprotein M and ESCRT in herpes simplex virus type 1 assembly
Herpes simplex virus type 1 (HSV-1) has a large linear double-stranded DNA genome in an icosahedral capsid shell, a cell-derived lipid envelope and a proteinaceous tegument layer. There are over fifty viral proteins and many host proteins identified in HSV-1 virions. The final formation of mature …
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The role of autonomic neurons in the pathegenesis of herpes simplex virus infection
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are major human pathogens. HSV establishes latency in the nervous system and reactivates to cause recurrent disease, resulting in transmission of progeny virions to naïve individuals. Though HSV-1 and HSV-2 share similar structure and genes, they …
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The Impact Of Interferon Regulatory Factor 3 On The Immune Response To Herpes Simplex Virus Type I Infection
… in control of herpes simplex virus type I: HSV-1) infection and relies on specific recognition molecules to rapidly signal viral infection via interferon regulatory factor-3: IRF-3) -dependent pathways. The absence of these recognition molecules or the loss of IRF-3 would be predicted to …
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus, often acquired during childhood, that currently infects more than 50% of the human population. The symptoms of infection are herpetic lesions that frequently appear throughout a host's life in response to stress in the orofacial or …
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A Host Regulatory Circuit of HSV Gene Expression
HSV-1 is a persistent pathogen within society due to its ability to establish a lifelong infection within the host, causing severe symptoms in a cohort of those infected. HSV-1 alternates intermittently between productive and latent cycles, where the immediate-early protein ICP0 plays a critical …
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
… viruses rely on host cells to replicate. Hsv-1 is a large double stranded DNA virus which is the cause of common cold sores and corneal blindness in humans. The defining feature of HSV-1 is its ability to exist in two discrete states. During lytic infection, productive virus replication …
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Stress hormones epinephrine and corticosterone modulate herpes simplex virus 1 and 2 productive infection and reactivation primarily in sympathetic, not sensory, neurons
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with exacerbation of clinical symptoms and induction of recurrences in humans and …
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