Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 152 for “"HSV"”.
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A Role for the HSV Tegument Protein pUL16 in Modulating Cellular Energy Metabolism during HSV-2 Infection
… several processes during Herpes simplex virus (HSV) infection, including virion morphogenesis and cell-to-cell spread of infection. Recent literature has also demonstrated that HSV-1 pUL16 localizes to distinct regions of mitochondria. Consistent with these findings, our proximity-dependent …
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A Host Regulatory Circuit of HSV Gene Expression
HSV-1 is a persistent pathogen within society due to its ability to establish a lifelong infection within the host, causing severe symptoms in a cohort of those infected. HSV-1 alternates intermittently between productive and latent cycles, where the immediate-early protein ICP0 plays a critical …
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The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
Herpes simplex virus type 1 (HSV-1) is a globally prevalent neurotropic virus that establishes lifelong latency within trigeminal ganglionic neurons and undergoes periodic reactivation, resulting in recurrent mucocutaneous and ocular disease. In severe manifestations, HSV-1 infection can progress …
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Investigating HSV-1 pUL56 mediated antagonisation of DNA sensing mechanisms
Herpes Simplex Virus 1 (HSV-1) is a large, enveloped DNA virus that infects around two-thirds of the world population. HSV-1 is known to successfully remodel the host cell microenvironment to allow for efficient replication and propagation of progeny virions. One of the ways in which HSV-1 achieves …
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Effect of Chinese Knotweed Extract on HSV-1 Infection of Vero Cells
<p>HSV-1 is an opportunistic virus responsible for infecting the majority of the global population. The ability of this virus to strategically alternate between lytic and latent states has made the development of effective treatments challenging. Polygonum multiflorum (Chinese Knotweed, CK) is a …
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Clinical Implications of HIV-1, HSV-2 Co-infection and Opportunities for Intervention
HSV-2 may have adverse consequences in HIV. I evaluated the impact of HSV-2 co-infection on (highly active antiretroviral therapy)-untreated HIV infection in a systematic review of observational studies (study 1) and a retrospective cohort (study 2). I further evaluated whether HSV reactivation …
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DISCOVERY OF LIGNIN SULFATE AS A POTENT INHIBITOR OF HSV ENTRY INTO CELLS
… in the biology are known to infect humans. HSV- I is the most common one, causing oral lesions and sporadic encephalitis. These infections are highly prevalent affecting at least one in three individuals in the United States.The entry of the herpes virus into the cell is a two-step process. …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
Herpes Simplex Virus (HSV) – 1 also known as Human Herpes Virus (HHV) – 1 is a common infectious agent of humans which can cause a wide variety of clinical outcomes, ranging from mild mucocutaneous lesions to long term morbidity and possible mortality. Viral entry into cells requires the …
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Investigating the structure and function of HSV-1 tegument proteins: UL7 and UL51
Herpes simplex virus-1 (HSV-1) has a large double-stranded DNA genome encased within an icosahedral capsid. The capsid is surrounded by a protein-rich layer, termed tegument, and a membranous envelope containing viral glycoproteins. HSV-1 genome replication and encapsidation occurs in the nucleus, …
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Relating the structure of the HSV-1 UL25 DNA packaging protein to its function
The herpes simplex virus type 1 (HSV-1) UL25 protein (pUL25) is a minor capsid protein that is essential for packaging the full-length viral genome into preformed precursor capsid. It is also important in virus entry and recently has been implicated in the egress of the virus from the cell (Coller …
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Expansion und retroviraler Gentransfer eines Suizidgens (HSV-TK) in humanen T-Lymphozyten zur adoptiven Immuntherapie
… für die Herpes-simpex-Virus-Thymidinkinase (HSV-TK) kodiert und ein Resistenzgen gegen das zytotoxische Antibiotikum Neomycin trägt. Es konnte gezeigt werden, dass mit X-Vivo 15 Kulturmedium unter Zugabe von 5% humanem AB-Serum eine etwa 60-fache Expansion der Ausgangszellmenge möglich ist. …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
In order to develop an effective vaccine for HSV-2 it is important to adequately understand the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available for this animal are limited. Consequently, many reagents and assays used …
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Developing Methods to Study Pathogenesis and Immune Response to HSV-2 in the Guinea Pig Model
In order to develop an effective vaccine for HSV-2 it is important to adequately understand the immune response in the proper animal model. Guinea pigs fully recapitulate human HSV-2 disease, but reagents and assays available for this animal are limited. Consequently, many reagents and assays used …
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Studies on the interaction of HSV-1 multifunctional protein ICP27 with the nuclear pore complex proteins
Herpes simplex virus (HSV-1) ICP27 is a multifunctional immediate early (IE) protein, required for expression of several early and late genes and acts at transcriptional and posttranscriptional levels. ICP27 contains both a nuclear localization signal and a nuclear export signal and shuttles …
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Investigating synergy: Mathematical models for the coupled dynamics of HIV and HSV-2 and other endemic diseases
… investigate synergy: synergy between HIV and HSV-2 or between humans and mosquitoes in a malaria study. Each of the three coupled disease models addresses different epidemiological questions with regard to gender or disease structure in the context of sexually-transmitted diseases (STDs), …
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Modeling of NK Cells in Pediatric Patients With Unusually Severe or Recurrent HSV Using High-Dimensional Flow Cytometry
<p>HSV infection is broadly spread all over the world with some patients having severe and/or recurrent HSV infections. Our lab studies human Natural Killer (NK) cells, which are important in innate immune responses to viral infections and tumors. A publication in 2013 by Ornstein et al from our …
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Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… with oncolytic herpes simplex I virus (oHSV) in a glioblastoma model. We examined the effects of oHSV on FAK signaling by looking at FAK phosphorylation at different time points post-infection and saw that FAK was activated by viral infection at earlier time points. When combining …
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The role of autonomic neurons in the pathegenesis of herpes simplex virus infection
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are major human pathogens. HSV establishes latency in the nervous system and reactivates to cause recurrent disease, resulting in transmission of progeny virions to naïve individuals. Though HSV-1 and HSV-2 share similar structure and genes, they …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… infection strategy of herpes simplex virus (HSV) consists of an initial primary lytic infection in epithelial cells, followed by establishment of lifelong latency in sensory and autonomic neurons of the peripheral nervous system that innervate the site of infection. Any cellular stress …
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