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Showing 1 to 20 of 22 for “"HSPGs"”.

  1. Role of the interaction of proHB-EGF with heparan sulfate proteoglycans

    Prince, Robin NeelyMassachusetts Institute of Technology2009

    … ability to bind heparan sulfate proteoglycans (HSPGs). The interaction of HB-EGF with HSPGs has been previously studied only with the soluble (autocrine/paracrine) form of the protein (sHB-EGF), produced after proteolytic cleavage of the transmembrane form (proHB-EGF) from the cell surface. It …

    mit Repository record

  2. Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv

    김, 혜진2014

    … both cell surface heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) that are highly negatively charged molecules known as endocytic receptors for a variety of ligands. Treatment of soluble HS or CS reduced cell surface binding of 3D8 scFv to intact HSPGs. …

    ajou Repository record

  3. Fluorous assisted one-pot oligosaccharide synthesis and chemical synthesis of homogeneous heparan sulfate proteoglycan

    Yang, Bo2012

    … this method. Hpearan sulfate proteoglycans (HSPGs), including syndecans and glypicans, are ubiquitous components of mammalian cell surface and extracellular matrix and they play important roles in various biological processes such as cancer development, angiogenesis. viral infection and wound …

    msu Repository record

  4. Characterisation of human surfactant protein A and recombinant human vimentin in their modulation of HPV16 pseudovirus infection

    Carse, SineadDepartment of Integrative Biomedical Sciences (IBMS)2019

    … heparan sulphate proteoglycans (HSPGs) than control particles. Removal of surface HSPGs on NIKS cells decreased HPV16-PsVs cell surface binding and internalisation, while pre-incubation of HPV16-PsVs with rhVim decreased viral particle binding and internalisation to a greater …

    cape-town Repository record

  5. Characterization of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) interaction with the Bovine Aortic Endothelial (BAE) cell surface: Examination of the Role of Heparan Sulfate Proteoglycans (HSPG)

    Parghi, NiravVirginia Tech1998

    … was seen that inactivation of the cell surface HSPGs with 75 mM sodium chlorate did not affect IGFBP-3 binding. Further, there have been reports of inhibition of IGFBP-3 binding by heparin in the media. Hence, the most probable interaction of HSPG with IGFBP-3 occurs in the extracellular region, …

    vt Repository record

  6. Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans

    Au, Rebecca2027

    … target receptors. Heparin sulfate proteoglycans (HSPGs), such as LON-2 glypican and UNC-52 perlecan, are likely candidates for the ECM proteins that interact and guide sAPL-1. The disruption of APL-1 causes phenotypical changes, including in learning, reproduction, and memory; these defects are …

    cuny Repository record

  7. The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability

    Guss, Ellen JaneMassachusetts Institute of Technology2023

    Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles. Perlecan is a secreted ECM-localized HSPG that contributes to tissue integrity and cell-cell communication. In this thesis, I …

    mit Repository record

  8. Role of heat shock protein 70 and sulphatases 1 and 2 in apoptosis induced by cytotoxic cells of the immune system

    Demiroglu, Sara Yasemin2012

    … MEFs erklärt werden. Ein Verdau von HSPGs durch die Heparinasen II und III erhöhte die Effizienz der Infektion weiter. Gleichermaßen führte auch ein genetischer Defekt von HSPGs in CHO-Zellen zu einer erhöhten Infektionsrate.Diese Ergebnisse lassen vermuten, dass HSPGs eher als Decoy …

    goettingen Repository record

  9. Cryo-electron microscopy of HPV16 pseudovirions reveal changes in capsid conformation upon furin cleavage

    Marx, Melissa LaurenDepartment of Clinical Laboratory Sciences2021

    … via binding to heparan sulphate proteoglycans (HSPGs). Cleavage of L2 by a host protease, furin, is necessary for infection and is thought to facilitate a conformational change in the virus capsid. Furin cleavage may affect the ability of HPV to bind to sulphated glycoproteins and a HSPG …

    cape-town Repository record

  10. Characterisation of novel matrix-binding interactions for latent transforming growth factor-β-binding protein-2 (LTBP-2), with emphasis on heparin and heparan sulphate proteoglycans.

    Parsi, Mahroo Kamkar2010

    … yet unidentified heparan sulphate proteoglycans (HSPGs), have also been identified as playing important roles in this process. Fibrillins-1, -2, -3 and latent transforming growth factor-β binding protein (LTBP)-1, -2, -3, -4, associated components of fibrillin-microfibrils, make up a superfamily …

    adelaide Repository record

  11. Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells

    Li, Qiao,S. M.Massachusetts Institute of Technology.Massachusetts Institute of Technology2019

    … stem cell niche. Heparan sulfate proteoglycans (HSPGs) are found on the membrane of all animal cells and have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions. Multiple heparan sulfate (HS)-binding growth factors, such as Wnt, bone morphogenetic proteins …

    mit Repository record

  12. CHARACTERIZATION OF THE INTERACTION BETWEEN HEPARAN SULFATE AND THE SPIKE (S) PROTEIN OF THE LATEST SARS-COV-2 VARIANTS

    MANDALARI, MARCOUniversità degli Studi di Milano2026

    … forming heparan sulfate proteoglycans (HSPGs). Due to the pronounced density of negative charge of HS, HSPGs play a key role in several biological processes, including cell hydration, intercellular communication, storage, protection, and exchange of biomolecules (e.g., cytokines, …

    milano Repository record

  13. Identifizierung, Charakterisierung und funktionelle Analyse der Bindungspartner von APRIL und TACI auf Monozyten und Dendritischen Zellen

    Willen, DanielaUniversität Heidelberg

    … APRIL haben Heparansulfat-Proteoglykane (HSPGs) gebunden und sind daher möglicherweise auch in vivo mit HSPGs komplexiert. Die Ergebnisse dieser Arbeit zeigen, dass APRIL über seine Heparinbindedomäne Proteoglykane auf extravasierten Monozyten bindet und dadurch Zell-Zell-Anlagerung von …

    heid-diss Repository record

  14. On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.

    Welch, JohannaDepartment of Oncology, Clinical Sciences, Lund University2010

    … of cell surface heparan sulphate proteoglycans (HSPGs) by anti-HS antibodies inhibits the bioavailability of exogenous polyamines, and that combined targeting of polyamine biosynthesis by α-difluoromethylornithine (DFMO) and HSPG-dependent uptake by a HIV-1 trans-activator of transcription (TAT) …

    lund Repository record

  15. Mechanisms of Molecular Chaperone Surface Binding and Endocytosis: Insights into the Molecular Basis for GRP94 Immune Function

    Jockheck-Clark, Angela Roberta2010

    … cell surface heparan sulfate proteoglycans (HSPGs) were identified as novel cell surface binding sites for GRP94.NTD on MEF cells. This conclusion was established using three distinct experimental approaches. GRP94.NTD surface binding was significantly decreased following heparin …

    duke Repository record

  16. Characterisation of the pro-regenerative extracellular matrix in the zebrafish spinal cord

    Lake, Elizabeth JesseThe University of Edinburgh2024

    … (mHeps) of heparan sulphate proteoglycans (HSPGs) indicate that a densely-sulphated glycan structure shown to be anti-regenerative in MC-Inj (mHep1) stimulates axonal regeneration in the zebrafish. A screen of specifically modified variations on this structure revealed that the responses of …

    edinburgh Repository record

  17. Analysis of Cellular Factors Involved in Adeno-Associated Virus Type 2 Entry

    Bess, Cameron Dale

    … not affect AAV infection. Our data shows that HSPGs play a critical role in chaperoning AAV into a macropinocytic pathway, which leads to productive infection.</p>

    rockefeller Repository record

  18. The Role of Stromal-Derived Factors in Neuroblastoma Differentiation

    Gaviglio, Angela L.2016

    … proliferation. Heparan sulfate proteoglycans (HSPGs) and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor (EGFR), leading to activation of the ERK1/2 and STAT3 pathways and upregulation of the inhibitor of DNA …

    duke Repository record

  19. The effect of scaffold physical properties on endothelial cell function

    Murikipudi, SylajaMassachusetts Institute of Technology2010

    … Pa. Secretion of heparan sulfate proteoglycans (HSPGs), which inhibit smooth muscle cell growth, is maximal at low moduli and flat at high moduli. Secretion of growth factors such as FGF2 and PDGF-BB were also modulus responsive. Inhibition of smooth muscle cell growth rose as modulus decreased …

    mit Repository record

  20. The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency

    Eugster, ChristinaTechnische Universität Dresden

    The Drosophila Lipoprotein particles bear lipid-linked morphogens on their surface and are required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show …

    qucosa-diss

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