Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"HSPC"”.
-
The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… leads to Hematopoietic Stem and Progenitor Cell (HSPC) expansion that underlies monocytosis and neutrophilia, coinciding with increased cell surface expression of the common β subunit of the Granulocyte-macrophage colony-stimulating factor (GM-CSF) /Interleukine 3 (IL-3 receptor (CBS) in the bone …
-
Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… hematopoietic stem/progenitor cells (HSPC) isolated by high aldehyde dehydrogenase activity (ALDHhi) reduce hyperglycemia after transplantation into streptozotocin (STZ)-treated NOD/SCID mice. However, UCB-derived ALDHhi cells are rare and expansion without the loss of regenerative …
-
Mapping the transcriptional landscape of haematopoietic stem and progenitor cells
… of haematopoietic stem and progenitor cells (HSPCs). Individual haematopoietic stem cells (HSCs) decide between self-renewal and differentiation and can generate all mature cell types. Cell-fate decisions are made at the single-cell level and are governed by regulatory networks. Dysregulation …
-
The role of EGFR, HER 2-4, heregulin and downstream signalling in prostate adenocarcinoma
… cohort pilot study of paired hormone sensitive (HSPC) and refractory (HRPC) specimens demonstrated HER2/HER4 as positively prognostic in HSPC. Heregulin (HRG), a principle HER family ligand, has previously been noted to have a differential effect on HSPC (decreased proliferation) and HRPC …
-
Monocytic Cells Mediate Granulocyte-Colony Stimulating Factor-Induced Mobilization of Hematopoietic Stem and Progenitor Cells
… of hematopoietic stem and progenitor cells: HSPCs) are tightly held within specialized areas of the bone marrow collectively referred to as the `hematopoietic stem cell niche.' In response to various forms of stress, such as infection or hemorrhage, or following administration of a variety of …
-
Development of a novel approach to expand umbilical cord blood-derived haematopoietic stem/progenitor cells ex vivo for clinical transplantation
… source of haematopoietic stem/progenitor cells (HSPC) for haematopoietic stem cell transplantation (HSCT). One factor limiting the wider use of UCB for transplantation is the relatively low cell dose from a UCB unit compared to bone marrow (BM) and peripheral blood (PB). To overcome this barrier, …
-
Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… that ectopic expression of Nfix in primary mouse HSPC extended their ex vivo culture from 20 to 40 days. HSPC overexpressing Nfix displayed hypersensitivity to supportive cytokines and reduced apoptosis when subjected to cytokine deprivation compared to controls. Ectopic Nfix resulted in elevated …
-
The Characterization of Hematopoiesis in Murine Fetal Bone Marrow
… of the hematopoietic stem and progenitor cell (HSPC) compartment, functional assessment of specific progenitor populations, and single-cell RNA-sequencing (scRNA-Seq) of the hematopoietic and stromal FBM environment. Here, we provide the first report of the presence of bona fide HSCs within the …
-
Liposomes generated from proliposomes for treatment of glioma using Momordica charantia extracts
… prepared from SPC (Soy phosphatidylcholine) and HSPC (Hydrogenated soy phosphatidylcholine) phospholipids. Drug-free liposomes prepared by proliposomes were compared with the conventional method of producing liposomes. Conventional liposomes are biocompatible and biodegradable, however, they are …
-
Fibrin targeting microbubbles for the detection of nascent surgical adhesions
… (SPC), hydrogenated soy phosphatidylcholine (HSPC) and distearoylphosphatidylcholine (DSPC)) were compared to show the effect of lipid saturation and targeting protein conjugation on microbubble stability and surface charge. The binding specificity of the targeted microbubbles was shown by …
-
Development of Liposome Drug Delivery Systems for Anti-Glioma Therapy
… Three different lipid phases: SPC:Chol, HSPC:Chol or DPPC:Chol in 1:1 mole ratio were used in each liposomal formulation to compare their size, size distribution, zeta potential, pH and morphology. The size of the liposomes was then reduced into nanometre size range. DPPC-liposomes …
-
The role of the bone marrow niche and G-CSF in osteochondral repair
… to haematopoietic stem and progenitor cell (HSPC) maintenance and the dynamics of this are disrupted by osteochondral repair procedures. In addition, the bone marrow niche can be further manipulated by the HSPC mobilising agent granulocyte-colony stimulating factor (G-CSF). This cytokine has …
-
Charting the single-cell transcriptional landscape of haematopoiesis
… of the haematopoietic stem and progenitor cell (HSPC) compartment. To build a comprehensive map of this landscape, 1,654 HSPCs from mouse bone marrow were profiled using single-cell RNA-sequencing. Analysis of these data generated a useful resource, and reconstructed changes in gene expression, …
-
Lifestyle and exercise effects on circulating progenitor cells in children and adults
… monocytes and the relationship between HSPCs (a subset of CPCs) in children with overweight and obesity and cognition. We collected blood from children and measured HSPC and inflammatory monocyte content. Next, we correlated measures of cognition with HSPC concentrations and observed …
-
The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment
… hematopoietic stem and progenitor cells: HSPC) are restricted to the bone marrow and are rarely observed in peripheral blood. Under certain circumstances, however, this regulation is loosened and significant numbers of HSPC are released to the circulation, a process termed "mobilization." …
-
Investigating clonal hematopoiesis in rhesus macaque and human
… the expansion of blood cell output from one HSPC linked to an acquired somatic mutation conferring a competitive advantage. While clonality is a feature of hematological malignancies, recent large deep sequencing studies have revealed that clonally-expanded HSPC with specific somatic …
-
Cryomilling of Aluminum-based and Magnesium-based Metal Powders
… process called high shear powder consolidation (HSPC) is used to densify as-received and as-milled powders with minimal growth. The construction of a cryomill, along with a modification for improving process yield, has provided a platform for the study of nanocrystalline metals. It has been shown …
-
Cholinergic signals promote the quiescence of normal or leukaemic stem cells through the activation of the α7-nicotinic receptor in bone marrow mesenchymal stromal cells
… signalling in the BM microenvironment promotes HSPC proliferation and accelerates leukaemogenesis. Blockade of peripheral α7nAChR renders chemoresistant quiescent AML cells sensitive to induction chemotherapy and shows synergistic therapeutic effects in the AML model in vivo. These results …
-
The influence of exercise training on the bone marrow microenvironment in obesity and cancer
… Hematopoietic stem and progenitor cells (HSPCs) are responsible for the maintenance and generation of blood cells in circulation. HSPCs primarily reside within the bone marrow (BM) in distinct niches that secrete soluble cytokines, growth factors, or utilize cell-to-cell interaction to …
-
Dissecting cellular crosstalk and genetic perturbations in haematopoietic regulation
Haematopoietic stem and progenitor cells (HSPCs) proliferate and differentiate to produce a large number of mature blood and immune cells on a daily basis while maintaining themselves as the reservoir for lifelong haematopoiesis. Haematopoiesis is dynamically regulated by activating …
Page 1 of 2