Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"HSP27"”.
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Hsp27 and Chemotherapy-Induced Autophagy As Biomarkers In Osteosarcoma
… puncta (a marker of autophagy) and presence of HSP27 (heat shock protein 27) in cancer cells within pre-treatment biopsy, post-treatment surgical resection, and metastatic osteosarcoma specimens by immunohistochemistry in 260 patients. LCB3+ puncta expression was seen in 34% of pre-treatment. …
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MOLECULAR ROLES OF HSP27 IN IMPROVING MONOCLONAL ANTIBODY PRODUCTION OF CHO CELLS
… BIOLOGICS CAPABILITIES. HEAT SHOCK PROTEIN 27 (HSP27) WAS REPORTED TO BE HIGHLY EXPRESSED IN HUMAN CELLS AND HAVE ANTI-CYTOTOXIC FUNCTIONS. HOWEVER, HSP27 EXPRESSION WAS DOWN-REGULATED TOWARDS THE LATE-EXPONENTIAL AND STATIONARY GROWTH PHASE OF CHO FED-BATCH BIOREACTOR CULTURES, MAKING IT A …
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Cytotoxic effects of electron carriers are inhibited by Hsp27 in breast cancer cell lines
Human breast cancer cell lines DC4, DB46, MCF-7, MDA-MD-435 were incubated with cytochrome c at 5 x 10-7M, 5 x 10 -6M and 5 x 10-5M. Human colon cancer cell line, RKO, and normal human lung fibroblast cell line, HFL1, were incubated with cytochrome c at 5.6 x 10-8M, 5.6 x 10-7M and 5.6 x 10-6M. …
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Ueber die Beteiligung der Hitzeschockproteine HSP27 und HSP70 an einer Resistenz, Resistenzentwicklung unter CMF-Therapie
… das in Mamma-Karzinomen stark exprimierte HSP27 und HSP70 scheinen hier beteiligt. Hitzeschockproteine sind Teil eines durch Noxen induzierten Mechanismus, welcher Schutz vor weiterer Noxenexposition verleiht, also die entsprechenen Zellen im Unterschied zu nicht exponierten Kontrollzellen …
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Μελέτη των μοριακών μηχανισμών ανάπτυξης του οφθαλμικού πτερυγίου στον άνθρωπο : ο ρόλος του μεταγραφικού παράγοντα HIF-1α, της πρωτεΐνης pVHL και των πρωτεΐνών θερμικού σοκ
… των πρωτεϊνών θερμικού σοκ (Hsp90, Hsp70, Hsp27). Δόθηκε έμφαση στην ταυτοποίηση της συν-έκφρασης του HIF-1α και της Hsp90, η οποία, σύμφωνα με προηγούμενα ερευνητικά δεδομένα, συνδέεται και σταθεροποιεί τον HIF-1α με αποτέλεσμα την αύξηση της μεταγραφικής του δραστηριότητας. Για την …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… migration and activation of p38 MAPK and HSP27 signaling compared to GFP control cells. Deletion of the Acidic Domain increases cell adhesion and reduces SPARC-induced migration and p38 MAPK/HSP27 signaling. The EGF-like Module Deletion mutant decreases SPARC-induces migration and …
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Mechanism-Based Strategies to Enhance The Actions of A
… the levels of antiapoptotic proteins HSP70 and HSP27, which may lead to cell death resistance. The increase in HSP70 and HSP27 protein levels is due to the activation of the transcription factor HSF-1 binding to the promoter region of HSP70 and HSP27 genes. HSF-1 binding subsequently promotes …
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Photobiomodulation with IR1072nm in the murine CNS: in vitro and in vivo studies
… factor (BDNF) and heat shock protein HSP27, and HSP40 and HSP90 was observed in both CD-1 and TASTPM Alzheimer disease mice, which may underlie the severe learning deficits seen in these mice. Acute whole body treatments of CD-1 mice in vivo comprising ten consecutive daily 6 minute …
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Heat shock protein 27 inhibition of the caspase cascade in human breast cancer cells
… is an over-expression of Heat Shock Protein 27 (HSP27), the cell does not obey the death signals that it receives. In this study, the molecular mechanism for the HSP 27 inhibition of the caspase cascade is described in human breast cancer cells that were engineered to constitutively express HSP …
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The Role of Autophagy In The Sensitivity of Osteosarcoma Cells to Gemcitabine Treatment
… that phosphorylation of Heat Shock Protein 27 (HSP27) correlated with autophagy as a mechanism of cellular resistance in different OS cell lines. Taken together, these results suggest that GCB induces autophagy in OS cells through the AKT/mTOR pathway and that when HSP27 is induced inhibition of …
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Stress Conditioning and Heat Shock Protein Manipulation for Bone Tissue Engineering
… hours for VEGF secretion and MMP-9 gene) induced HSP27 and HSP70, secretion of VEGF (protein), and suppression of MMP-9 (gene) more than heating or tension alone. HSP70 silencing followed by heating (44°C, 8 minutes) enhanced expression of HSP27. Mitogenic activity was inhibited by heating with …
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The exercise-induced expression of heat shock proteins in human skeletal muscle : the role of evaluated muscle and core temperature and the influence of training status
… did not induce significant increases in either HSP27, aB-crystallin, manganese superoxide dismutase (MnSOD) protein content or the activity of superoxide dismutase (SOD) and catalase. When examining baseline protein levels, HSC70, HSP27 and aB-crystallin appeared consistently expressed between …
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
… of heat shock proteins such as HSP70, HSP40 and HSP27. Such protein assist the folding of newly synthesized or misfolded proteins, preventing their aggregation. Therefore, HSP90 inhibitors protect against protein toxicity and reduces brain aggregate to form in AD. The HSP90 protein crystal …
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Effective Cancer Therapy Design Through the Integration of Nanotechnology
… and the alginate phantom. Up-regulation of HSP27, 70 and 90 was witnessed in samples that achieved sub-lethal temperature elevations. Tuning of laser parameters permitted dramatic temperature elevations, decreased cell viability, and limited HSP induction in NP-containing samples compared to …
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Development And Study Of Inhibitors Of Heat Shock Protein 70 Induction
… HSP70 induction and at the same time not enhance HSP27 phosphorylation. The derivatives that inhibit HSP70 induction were also found to be inhibitors of both Ck2 kinase and CaMKII kinase that are known to activate heat shock transcription factor 1 that leads to HSP70 induction. A biotinylated …
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Hsp90 as a molecular target
… proteins include Hsp70 family members, Hsp27 and gp96, thereby suggesting the role of Hsp90 co-chaperones in compensating for Hsp90 function post Hsp90 inhibition. Moreover, members of the glycolysis/glucogenesis pathway were also upregulated, demonstrating increased dependency on …
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Identification of tumour-associated gycoproteins recognised by the lectin from Helix pomatia in breast cancer
… HnRNP H1, HnRNP D-like, HnRNP A2/B1 as well as Hsp27, GFAP and ENO1. The recognition of HnRNPs, Hsp 27 and ENO1 by HPA correlated with O-GlcNAcylation of these proteins. Interestingly, these HPA-binding glycoproteins were either absent or showed decreased levels in the non-metastatic breast …
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The proteomic analysis of resistance to anticancer therapy in human breast cancer
… GST-M3, cytokeratin 17, peroxiredoxin 4 and HSP27 (which were associated with cisplatin resistance) and L-Plastin, GST-M3 and cytokeratin 17 (which were associated with radio-resistance). These provide interesting targets and are worthy of further studies.Although 2DE-MALDI-TOF MS remains the …
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Influence of the Atrial Natriuretic Peptide on TNF- αα α -activated human endothelial cells
… inhibition of p38 MAPK and its downstream target HSP27. Furthermore we could report here for the first time a decrease in TNF- -induced macromolecule permeability by ANP. The deactivation of p38 MAPK was demonstrated to be mediated via a significant transcriptional induction of the MKP-1 by ANP. …
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