Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"HSF-1"”.
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Components Required for the Death and Degradation of the Linker Cell in C. Elegans
… in part, through the stressrelated protein HSF-1, and subsequent upregulation of members of the ubiquitin proteasome system. How exactly HSF-1 is post-translationally regulated to either commit to cell survival or cell death is not currently known. Using a protein interaction screen and …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… the transcription factor, heat shock factor-1 (HSF-1) and NFκB-DNA binding activity in response to a concentration of 31 mM D- glucose in peripheral blood mononuclear cells (PBMCs) from patients with TIDM with and without microvascular complications. Hyperglycaemia induced significant increases …
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
… function is to regulate the heat shock factor-1 (HSF-1) transcription factor, which is the key regulator of the heat shock response. Inhibition of HSP90 activates HSF-1 and the subsequent induction of heat shock proteins such as HSP70, HSP40 and HSP27. Such protein assist the folding of newly …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… death mediators require the heat shock factor HSF-1 for cell death. Importantly, HSF-1 function in linker cell death is distinct from, and competes with, its role in stress responses. My studies demonstrate that HSF-1, previously thought to be primarily protective, is a key downstream regulator …
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The effect of oral glutamine supplementation on gut permeability and heat shock protein regulation in runners with a history of gastrointestinal distress
… conditions. HSP70, heat shock factor 1 (HSF-1), and occludin were measured from each culture. Results: Core temperature was not different between exercise trials (39.40 ± .39 vs. 39.54 ± .22 for PLA vs. GLN, respectively, p>0.05). Resting plasma glutamine levels were significantly higher …
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Mitochondrial respiratory defects induces claudin 1 expression via ROS-mediated HSF1 activation
… factor binding site Heat Shock Factor1 (HSF1), which are known to be regulated by intracellular redox status. Subsequently, we found, that HSF-1 binds to the Cln- 1 promoter. HSF1 knockdown using siRNA decreased Cln-1 expression and invasive activity in SNU449. These results suggest that …
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Mechanism-Based Strategies to Enhance The Actions of A
… to the activation of the transcription factor HSF-1 binding to the promoter region of HSP70 and HSP27 genes. HSF-1 binding subsequently promotes HSP70 and HSP27 gene expression. Based on this, I hypothesized that inhibition of transcription/translation of HSP or client proteins would enhance …
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… loss of the heat shock transcription factor, HSF-1, disrupts the Jun kinase/Protein Phosphatase I equilibrium, increasing ACT-5 phosphorylation within a troponin-binding site. Phosphorylated ACT-5 accelerates decay of the intestinal terminal web and impairs cell junctions. Therefore, …
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Targeting mutant p53 in cSCCs
… in cSCC.<br/><br/>4. Heat shock factor 1 (HSF-1) is upregulated in cSCC compared to normal human keratinocytes (NHK). HSP90 inhibitors, 17-AAG and 17-DMAG, reduce mutant p53 protein levels suggesting that HSP90 plays a role in stabilising mutant p53 in cSCCs.<br/><br/>5. PR-619, a broad …