Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"HSF"”.
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Structural and Functional Evolution of Human Heat Shock Transcription Factors
… activation of Heat Shock Transcription Factors (HSFs) that regulate the expression of numerous genes involved in protein folding, protein degradation, and cellular survival. The studies presented here utilize a diverse array of techniques including yeast genetics, recombinant protein expression …
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Experimental and Theoretical Study of Hypergolic Solid Fuel Ignition and Combustion with Hydrogen Peroxide
… combustion behaviors of hypergolic solid fuels (HSFs) using rocket-grade hydrogen peroxide (RGHP) as the oxidizer. The HSFs used in this study were composed of low-density polyethylene (LDPE) as the fuel binder, along with two types of hypergolic additives: sodium borohydride (NaBH4) as the …
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The Houston Shakespeare Festival: A Strategic Plan
… sector and theatre community in Houston, HSF can broaden its impact on both the University and the City of Houston. By expanding the marketing and development capacity of the Festival, HSF can reach a new and increasingly diverse audience.
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Survival strategies of the human respiratory tract pathogen Haemophilus influenzae
… we demonstrate that Haemophilus surface fibrils (Hsf), which is expressed by encapsulated H. influenzae, binds vitronectin, a regulator of the terminal pathway of the complement system. Mapping of the membrane bound Hsf with gold-labelled specific antibodies in transmission electron microscopy …
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Components Required for the Death and Degradation of the Linker Cell in C. Elegans
… in part, through the stressrelated protein HSF-1, and subsequent upregulation of members of the ubiquitin proteasome system. How exactly HSF-1 is post-translationally regulated to either commit to cell survival or cell death is not currently known. Using a protein interaction screen and …
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Acute Sleep Fragmentation Induces Tissue-Specific Changes in Cytokine Gene Expression and Increases Serum Corticosterone Concentration
… sweeps every 20 sec (high sleep fragmentation; HSF), 120 sec (low sleep fragmentation; LSF), or the bar remained stationary (control). Trunk blood and tissue samples were collected after 24 h of SF. It was found that HSF is a potent inducer of inflammation in the periphery (IL-1β: adipose, …
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Adsorption of Blood Proteins onto Polysaccharide Surfaces
… serum albumin (HSA) and human serum fibrinogen (HSF), on two polysaccharide materials used for hemodialysis membrane applications: regenerated cellulose and cellulose acetate. The study aims to provide insight into the design of novel hemocompatible polysaccharide materials. Information such as …
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SysML Output Interface and System-Level Requirement Analyzer for the Horizon Simulation Framework
… the model and verify system requirements using HSF. Another goal was to expand the capabilities of the Horizon Simulation Framework by designing and develop a module that would allow users to define and analyze system-level requirements. To evaluate the effectiveness of both codes, the Aeolus …
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Testing and Verification for the Open Source Release of the Horizon Simulation FrameworTesting and Verification for the Open Source Release of the Horizon Simulation Framework
… realization. The Horizon Simulation Framework (HSF) is a time-driven modeling and simulation tool which attempts to optimize how a modeled system could perform a mission profile. After 15 years of development, the HSF team aims to achieve a wider user and developer base by releasing the software …
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An Investigation for Genetic Susceptibility to Type 1 Diabetes Mellitus and its Microvascular Complications
… the transcription factor, heat shock factor-1 (HSF-1) and NFκB-DNA binding activity in response to a concentration of 31 mM D- glucose in peripheral blood mononuclear cells (PBMCs) from patients with TIDM with and without microvascular complications. Hyperglycaemia induced significant increases …
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An Iteration on the Horizon Simulation Framework to Include .NET and Python Scripting
… to create it. The Horizon Simulation Framework (HSF) v3.0 is an aerospace modeling and simulation tool that allows the user to verify system level requirements in the early phases of the design process. A low fidelity model of the system that is created by the user is exhaustively tested within …
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The Role of Fatty Acids on Toll-like Receptor 4 Regulation of Substrate Metabolism with Obesity
… model, C57BL/6 mice were fed high saturated fat (HSF), high monounsaturated fat (HMF), and control diets for 10 weeks. Following the dietary intervention, animals were challenged with I.P. injections of either saline or LPS (~25μg/mouse), sacrificed 4 hours post-injection, and red and white …
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
… function is to regulate the heat shock factor-1 (HSF-1) transcription factor, which is the key regulator of the heat shock response. Inhibition of HSP90 activates HSF-1 and the subsequent induction of heat shock proteins such as HSP70, HSP40 and HSP27. Such protein assist the folding of newly …
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Regulatory Architecture of Non-Apoptotic Cell Death Program in C. Elegans
… death mediators require the heat shock factor HSF-1 for cell death. Importantly, HSF-1 function in linker cell death is distinct from, and competes with, its role in stress responses. My studies demonstrate that HSF-1, previously thought to be primarily protective, is a key downstream regulator …
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Haemophilus influenzae adhesins and the innate immune response
… that Haemophilus influenzae surface fibrils (Hsf) may increase the bacterial survival by interacting with vitronectin in serum. We also describe the isolation and characterization of a novel H. influenzae adhesin designated protein E (PE). PE was isolated by using an IgD myeloma serum which …
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The effect of oral glutamine supplementation on gut permeability and heat shock protein regulation in runners with a history of gastrointestinal distress
… conditions. HSP70, heat shock factor 1 (HSF-1), and occludin were measured from each culture. Results: Core temperature was not different between exercise trials (39.40 ± .39 vs. 39.54 ± .22 for PLA vs. GLN, respectively, p>0.05). Resting plasma glutamine levels were significantly higher …
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Modeling and Simulation of Vehicle Performance in a UAV Swarm Using Horizon Simulation Framework
… models are written in Python to expand the HSF scripting capability and include airborne scenarios. The simulation study focuses in the variation of three parameters in the repelling pheromone model. The first two are the update and deposit parameters with values of 2, 10, and 18. The third …
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Comparative analysis of desiccation responses in three Xerophyta species at two stages of seedling development
… TF families, including Heat Shock Factors (HSFs), A-T hook factors (AHLs), and C2H2 Zinc Finger Proteins (ZATs). The gene ontology enrichment showed that the HSF, AHL, and ZAT motif containing OGs that were up-regulated are involved in water deprivation, abscisic acid response, and oxidative …
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Mitochondrial respiratory defects induces claudin 1 expression via ROS-mediated HSF1 activation
… factor binding site Heat Shock Factor1 (HSF1), which are known to be regulated by intracellular redox status. Subsequently, we found, that HSF-1 binds to the Cln- 1 promoter. HSF1 knockdown using siRNA decreased Cln-1 expression and invasive activity in SNU449. These results suggest that …
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Genetics of age-related macular degeneration and Stargardt disease in South African populations
… software, PON - P and Human Splice Finder (HSF), were used for in silico data analysis. For the AMD subset: Available local indigenous southern African population - based genome - wide S ingle Nucleotide Polymorphism (SNP) chip (Affymetrix SNP6) data was used to identify SNPs within known …
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