Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"HSC70"”.
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Assessing The Therapeutic Viability of Hsc70 in ALS
… The constitutively expressed iso-form of Hsp70 – Hsc70 – also promotes motor neuron survival in primary cultures. Unfortunately, the price of both commercially available proteins makes them cost prohibitive to study, thus acquiring them by different means is necessary for further investigation. …
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
… and from this list three partners viz nucleolin, Hsc70 and HnRNP K were validated by immunoprecipitation and colocalization experiments. Importantly, results show that the interaction of TBX3 with Hsc70 is required for TBX3 protein stability and that nucleolin and TBX3 cooperate to promote MCF-7 …
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A role for HSC70 in regulating antigen trafficking and presentation during macronutrient deprivation
… on macronutrient status. Cytosolic chaperone HSC70 has been shown to play a role in endocytosis, macroautophagy, chaperone-mediated autophagy and proteolysis by the proteasome, potentially connecting distinct routes of antigen presentation. Here, altering the abundance of HSC70 was sufficient …
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Investigating the neuroprotective role of carboxyl-terminus of Hsc70-interacting protein (CHIP) in healthy aging
Throughout the past several decades, the elderly population has increased substantially. Yet, in spite of this enormous shift in age-related demographic characteristics, the cellular and physiological mechanisms underlying aging itself remain ill-defined. Their intrinsic complexity is further …
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Assembly and biochemical properties of a human chaperone/co-chaperone protein complex
… cycle. This study was carried out using human Hsc70 and HSJ1b as representatives of the Hsp70 and Hsp40 families respectively. The first step to understand this co-operation was to develop a strategy to isolate a complex of Hsc70 and HSJ1b suitable for structural studies. Previous studies have …
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Hap46, ein vielseitiges Protein
… über direkte Bindungspartner oder indirekt, über hsc70 als Brückenprotein, auf zelluläre Vorgänge wie Apoptose, Transkription, Signaltransduktion und Proliferation einwirken kann. Zudem fungiert es als Co-Chaperon von hsc70. Um die vielfältigen Funktionen von Hap46 innerhalb der Zelle besser …
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Topographical Differences in Stress Vulnerability in Experimental Parkinson's Disease
… in heat shock proteins (Hsps) such as Hsp70 and Hsc70, suggesting that allocortex needs to rely more on chaperone defenses. In support of this hypothesis, simultaneous loss of Hsp70/Hsc70 and proteasome activity was far more toxic in allocortex than neocortex, whereas facilitation of Hsp70/Hsc70 …
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… data from initial experiments reveal that Hsc70 interacts with TBX3, to possibly increase its protein stability, and that oncogenic c - Myc and AKT 1 positively regulat e TBX3 levels in ERMS. This, albeit preliminary data, suggest that Hsc70, c - Myc and AKT1 are responsible, in part, for …
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Funktion des SGT/NS1-Komplexes im Lebenszyklus autonomer Parvoviren
… konnte ausgeschlossen werden. Da SGT mit CSP und Hsc70 in neuronalen Zellen einen Chaperonkomplex bildet, kann vermutet werden, daß solch ein Komplex auch in der parvoviralen Replikation eine Rolle spielt. Allerdings konnte in dieser Arbeit Hsc70 nicht in APAR-Bodies nachgewiesen werden, so daß …
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The exercise-induced expression of heat shock proteins in human skeletal muscle : the role of evaluated muscle and core temperature and the influence of training status
… and individually variable increases in HSP70, HSC70 and HSP60 content with peak increases typically occurring at 48 h post-exercise. In contrast, exercise did not induce significant increases in either HSP27, aB-crystallin, manganese superoxide dismutase (MnSOD) protein content or the activity …
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Proteomic analysis of cellular models of neurodegeneration and mitochondrial dysfunction
… (Hsp60), heat shock cognate 71 kDa protein (Hsc70), glutamate oxaloacetate 2 (GOT2) and voltage-dependent anion channel 1 (VDAC1) were validated as potential markers of MPTP-induced toxicity using western blot analysis. In parallel, a study of the mitochondrial phosphoproteome was undertaken. …
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Physico-Chemical Characterisation of Disease-Related Protein-Protein Interactions in Solution
… of $\alpha$-synuclein fibrils with Hsc70 along with its co-chaperones DnaJB1 and Apg2 as well the interaction between BRICHOS and amyloid fibrils. These analyses provide mechanistic insight into the role of molecular chaperones in clearance of amyloid fibrils and inhibition of their …
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Characterization of a soybean BAG gene and its potential role in nematode resistance
… interaction with the molecular chaperone HSP70/HSC70. Members of the BAG protein family in animals and yeast function in apoptosis to regulate a range of activities from inhibition to promotion of cell death. However, much less is known about the role of BAG proteins in plants. A family of seven …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… co-factors were identified and from this list Hsc70 and nucleolin were validated by immunoprecipitation and colocalization experiments in MCF-7 and T47D breast cancer cells. Importantly, results show that the interaction of TBX3 with Hsc70 is required for TBX3 protein stability and that …
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Elucidating The Role of Rumi and O-Glucosylation In The Drosophila Eye
… addition, removing one copy of the chaperone <em>Hsc70-3 </em>enhances the <em>rumi<sup>–/–</sup></em> phenotype. Together, these data suggest that loss of <em>O-</em>glucose from Eys causes a defect in its proper folding, which leads to decreased Eys reaching the extracellular space and therefore …
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INVESTIGATION OF UNIQUE COENZYME A BIOSYNTHETIC AND REDOX FUNCTIONS IN Bacillus anthracis
… is a new member of the Acetate and Sugar Kinase/Hsc70/Actin (ASKHA) superfamily and modeling the pantothenate and ATP substrates into the active-site cleft provides a clear rationale for the absence of CoASH feedback inhibition. In addition, bioinformatics analyses indicate a widespread …
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Proteínas de choque térmico y vesículas de membrana como posibles inmunomoduladores producidos durante la infección por rotavirus de células epiteliales intestinales
… se liberan las proteínas de choque térmico (PCT) HSC70 y HSP70. Aunque tanto estas PCT como el TGF- ß1 se liberan principalmente de forma soluble, una parte de estas moléculas podrían liberarse de una forma asociada a vesículas de membrana (VM). Estas VM fueron concentradas por ultracentrifugación …
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Das Cystein String Protein von Drosophila melanogaster - Invivo-Funktionsanalyse verschiedener Proteindomänen am Modellsystem der larvalen neuromuskulären Synapse
… Es wurden Interaktionen mit den Proteinen HSC70, SGT, Syntaxin, Synaptobrevin/VAMP, verschiedenen Untereinheiten von G-Proteinen, Synaptotagmin, sowie spannungsabhängigen Ca2+-Kanälen beschrieben. csp-Nullmutanten CspU1 von Drosophila melanogaster zeigen einen temperatursensitiven Phänotyp, …
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Mechanism-Based Strategies to Enhance The Actions of A
… HSP70 and HSP27) and constitutive (HSP90â and HSC70) mRNA and protein levels were measured using real time RT-PCR and immunoblot assays. Treatment with 0.5 µM 17-AAG for 8 hours resulted in the induction of all HSP transcript and protein levels in the MM cell lines. This induction of HSP mRNA …
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Das Cysteine-String-Protein in Drosophila melanogaster: Molekulare und funktionelle Analyse verschiedener CSP-Mutanten; Ein Modell zur räumlich und zeitlich kontrollierten CSP-Expression
… zeigen, dass CSP in einem trimeren Komplex aus Hsc70/CSP/SGT vorkommt und bei der Exozytose wahrscheinlich als molekulares Co-Chaperon wirkt. Der Cysteinstrang liegt mehrfach palmityliert vor und ist für die Zielfindung des Proteins zur Vesikelmembran essentiell. In vorangegangenen Arbeiten …
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