Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"HSC niche"”.
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Refining Our Understanding of the Hematopoietic Stem Cell Niche
… studying blood-forming hematopoietic stem cells (HSCs) is to understand the mechanisms by which HSCs are maintained in the bone marrow, so that they can be grown outside of the body and used in lieu of or in combination with bone marrow transplantation to treat hematopoietic illnesses. HSCs, as …
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THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
… originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood lineages. Because of these features, HSCs are also the …
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Neuronal regulation of haematopoietic stem cell ageing and age-related blood disorders through the microenvironment
Haematopoietic stem cells (HSCs) give rise to all blood and immune cells in our body. Residing in the bone marrow (BM), HSCs are surrounded by numerous cell types and the associated extracellular matrix, which form a unique microenvironment known as ‘’HSC niche’’. Sympathetic neurons are important …
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Understanding Ontogeny and Optimizing Strategies to Promote Hematopoietic Engraftment Following In Utero Transplantation
… utero hematopoietic stem cell transplantation (IUHSCTx) have the potential to reduce fetal/neonatal morbidity/mortality due to hematological and immunological disorders. In some instances, IUHSCTx could also prevent disease-dependent organ damage/failure that many genetic diseases can exert during …
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Multigradient hydrogels to decode extrinsic regulation of hematopoietic stem cell fate
… this process are the hematopoietic stem cells (HSCs), primarily located within the bone marrow. They are housed in specific microenvironments (niches) that provide stochastically and temporally mutable signals that influence stem cell fate of differentiation, quiescence, self-renewal and …
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The Characterization of Hematopoiesis in Murine Fetal Bone Marrow
<p>Hematopoietic stem cells (HSCs) and their downstream progenitors are a heterogeneous population of cells that are indispensable for lifelong hematopoiesis and are often utilized in the clinic for the treatment of hematologic maladies via hematopoietic stem cell transplantation (HSCT). Over …
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Deciphering ARAP3 Functions in Hematopoiesis and Hematopoietic Stem Cells
… in hematopoiesis and hematopoietic stem cells (HSCs). In this thesis, we aim to elucidate the potential cell-autonomous and non-cell-autonomous roles of ARAP3 in hematopoiesis and HSCs using several conditional knockout (CKO) transgenic mouse models in addition to the KI/KI mutant mouse model. …
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Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
… hematopoietic stem cell transplantation (HSCT) has become a well established treatment modality for hematological malignancies and non-malignant disorders. Autologous and allogeneic hematopoietic stem cells (HSCs) mobilized into the peripheral blood (PB) have been used as a preferred …
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Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis
The haematopoietic stem cell (HSC) resides within a specific environment enabling it to retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is hypoxic, a milieu within which the HSC is protected from intrinsic and extrinsic stimuli. We have investigated the …
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Development of single-cell Raman spectroscopy for noninvasively screening the differentiation of living stem and progenitor cells in biomaterial platforms for 2D and 3D cell culture
… of research, only hematopoietic stem cells (HSCs) are approved by the Food and Drug Administration as a stem cell treatment. To solve the challenges involving the transplantation of stem cells for the treatment of malignant diseases, biomaterials have been studied for the optimization of …