Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 193 for “"HSC"”.
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Niche disturbances in Chronic Lymphocytic Leukaemia affect HSC residency and drug resistance
… early stage CLL revealed that short term (ST) HSCs and Common Myelo-Erythroid Progenitors (CMP/MEPs) are found in higher frequencies and are associated with a skewed differentiation into myeloid cells in vitro and progenitor cells are less likely to produce erythrocytes. These findings provide …
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Mitophagy-Mediated Regulation of ROS Homeostasis During HSC Activation Contributes to Cell Fate
… is a determinant of hematopoietic stem cell (HSC) activation status with low autophagy predicting activation of HSCs, and autophagy deficiency causing the spontaneous loss of quiescence and HSC exhaustion. Although an increase in mitochondrial activity has been suggested as the cause of HSC …
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Downregulation of Prdm16 Is Critical for HOXB4-mediated Benign HSC Expansion In Vivo
… of HOXB4 in hematopoietic stem cells (HSCs) leads to increased self-renewal without causing hematopoietic malignancies in transplanted mice. The molecular basis of HOXB4-mediated benign HSC expansion in vivo is not well understood. To gain further insight into the molecular events …
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Unfolded Protein Response (UPR) Signaling in Hepatic Stellate Cells (HSC) as a Key Regulator of Liver Fibrosis
… is the activation of hepatic stellate cells (HSCs), which secrete extracellular matrix (ECM) proteins such as collagen to form fibrotic scars. Activated HSCs produce vast amounts of fibrotic proteins that require folding and processing prior to secretion. Increased protein folding demands …
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… cells (HUVEC) or hematopoietic stem cells(HSCs)-mediated formation of microvascular networks in a biocompatible PCL-ßTCP hybrid scaffold in an immuno-compromised nude mouse. The PCL-ßTCP scaffold (30% PCL: 70% ßTCP; 70% porosity) with interconnected open pores was fabricated in 6x6x6mm …
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ZFP36L2 in Development and Adulthood: A Critical Regulator of Hematopoietic Stem Cell Homeostasis
… role in maintaining hematopoietic stem cells (HSC) during development. ZFP36L2-deficient mice exhibit severely impaired definitive hematopoiesis and die approximately two weeks after birth due to severe anemia, thrombocytopenia, and internal hemorrhage. Recent single-cell RNA sequencing …
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An exploratory multi-case study of the health and wellbeing needs, relationships and experiences of health and social care service users and the people who support them at home in a regional area of Scotland.
… and experiences of Health and Social Care (HSC) Service Users and the people who support them at home, in a regional area of Scotland. Current United Kingdom legislation sets a precedence of person-centred HSC that meets the health and wellbeing needs of Service Users and their families …
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Characterisation of human Haematopoietic Stem Cell differentiation and exit from quiescence at single cell resolution
… heterogeneous haematopoietic stem cell (HSC) compartments both in mouse and in human. However, how this diversity is regulated at the cellular and molecular level and when HSC multipotency is lost is still not known, in particular in humans. Quiescence is an important property of HSCs and …
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Untersuchung von antigenpräsentierenden Funktionen bei kultivierten hepatischen Sternzellen und transdifferenzierenden Myofibroblasten der Ratte
… these antigen-presenting hepatic stellate cells (HSC) in rat. Also changes of the antigen-presenting function in the fibrotic liver should be identified on a molecular and functional level. The antigen-presenting function of HSC is both in vitro, in the course of the transdifferentiation of HSC to …
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Monolithic beam to external column joints in reinforced concrete
The benefits of high strength concrete (HSC) in the construction of multi-storey buildings are commonly acknowledged. Past researchers have investigated the suitability of design codes for the use of HSC [1]. However, there are concerns about the shear behaviour of HSC beams and BCJ used in the …
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Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
Evidence suggests haematopoietic stem cells (HSCs) can migrate to injured liver and influence tissue repair. However, the molecular adhesive mechanisms governing HSC recruitment to injured hepatic microcirculation are poorly understood. These mechanisms were investigated in vivo following murine …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
… of endoglin in hepatic stellate cells (HSC). This characterization was performed particularly with regard to the impact and the function of endoglin in the transdifferentiation process of HSC into myofibroblast-like cells (MFB). Transdifferentiation of HSC into MFB plays a crucial role …
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Kryokonservierung von hepatischen Sternzellen der Ratte
… hepatic stellate cells was developed. Isolated HSC of the rat are used as a model of liver fibrogenesis. Many proceedings are studied on this cells, for example the biotransformation, the gene expression, the effect of pharmaceuticals, different kinds of transcriptional factors and many more. …
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Hydrogel platform to investigate the coordinated impact of niche signals on hematopoietic stem cell fate
Hematopoietic stem cells (HSCs) regulate the process of hematopoiesis, which is the formation and development of all the body’s blood and immune cells. The HSCs ability to either self-renew or differentiate in order to produce these populations is determined by a number of known as well as …
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Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… 80-90% is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid content and …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… is a key mediator of hepatic stellate cell (HSC) activation and extracellular matrix accumulation leading to fibrosis. Aim of the present study was to perturb the TGF-beta pathway in this process by overexpression of Smad7, an intracellular antagonist of TGF-beta signaling. Moreover, a new …
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Therapeutic application of dominant-negative PDGF beta-receptor in liver fibrosis
Upon liver injury hepatic stellate cells (HSC) undergo phenotype transformation with acquisition of myofibroblast-like features characterized by increased cell proliferation, motility, contractility and extra cellular matrix production. HSC activation is regulated by several cytokines and growth …
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Early Blood Cell Formation "in sickness and health, ´till death do us part"
Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to mature effector cells through a series of developmental steps. This is a tightly regulated, though a highly dynamic process: on the one hand, dysregulation in steady-state could lead to under- or …
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The Impact of Clinically Relevant Culture on Human Haematopoietic Stem Cells: A Kinetic Analysis at Single Cell Resolution
Haematopoietic stem cell (HSC) ex vivo gene therapy is now successfully used to treat an in-creasing number of monogenic disorders affecting the blood system. The ultimate efficacy of this therapy depends upon successful targeting of long-term haematopoietic stem cells (LT-HSCs), which are …
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Feedback Regulation of Human Hematopoietic Stem Cell Fate
Hematopoietic stem cell (HSC) fate decisions at least in part determine cellular composition of the hematopoietic system. It is known that differentiated blood cells produce ligands that act on HSCs to influence HSC fate. However, fundamentals underlying the feedback regulation of HSC fate are …
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