Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"HRASG12V"”.
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Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat
… SV40 large T antigen and oncogenic RAS (SV40LT-HRASG12V), a combination of oncogenes sufficient to transform mouse and rat cells. Additionally, Tian et al. have reported that high-molecular weight hyaluronan (HMW-HA) mediates the NMR’s cancer resistance and inhibition of HMW-HA signalling render …
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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… SCC remain elusive. Here we show that following HRASG12V activation, cancer stem cells rewire their gene expression program and trigger self-propelling, aberrant signaling crosstalk with their tissue microenvironment that drives their malignant progression. Surprisingly, the non-genetic, dynamic …
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Predictive Reporter System for Investigating Dose Dependency in Oncogene-Induced Senescence
… reflects the level of inducible oncogenic HRASG12V. This allows pre-induction sorting into subpopulations expressing differing levels of mVenus, which is reflected in differences in HRAS dose following induction. Using this system, we first validated that subpopulations expressing different …