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Showing 1 to 2 of 2 for “"HR1a"”.
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Towards Inhibition of Oncogenic RhoA Signaling using Stapled Peptides
… This work presents the investigation of the HR1a domain from the RhoA effector, PRK1/PKN1 kinase, as a starting point for peptide inhibitor design. HR1a binds to RhoA with nanomolar affinity and forms an anti-parallel coiled coil. This dissertation starts with mutagenesis studies on the …
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Structural and Biochemical Characterisation of the HR1 domains of the Protein Kinase C-related kinase family
… N-terminal Homology Region 1 (HR1) domains, HR1a, HR1b and HR1c. These are predicted antiparallel coiled coils which interact with the Rho proteins. While HR1a and HR1b domains have been studied in vitro, very little is known about the HR1c domain. This project aims to provide much-needed …