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Showing 1 to 20 of 54 for “"HPV-16"”.
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HPV 16 Strukturproteine als Vehikel zur Immunisierung
… Typen der humanpathogenen Papillomviren (HPV), z.B. HPV 16, sind ursächlich an der Entstehung von Gebärmutterhalskrebs und seinen Vorläuferläsionen beteiligt. Unter natürlichen Bedingungen erfolgt die Infektion mit HPV in undifferenzierten Epithelzellen des Stratum basale. Jedoch können …
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Expression of HPV-16 L2 in plants
… or apoplastic space were Expression of HPV -16 L2 in Plants used and it was found that targeting of the protein had no effect on its expression levels.
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Thema - 1. Herstellung von HPV-16 rekombinanten Pflanzenviren für die Produktion viraler Gene in Leguminosen : 2. Modulation einer HPV-16-DNA-Vakzine
… einem Pflanzen-Virus-Vektorsystem verschiedene HPV16 rekombinante Viren herzustellen. Als Träger der HPV16-Sequenzen wurde die RNA-2 des Cowpea Mosaic Virus verwendet. Ziel war die billige Herstellungsweise einer anti-HPV16-Vakzine in Pflanzen (Vigna unguiculata) im großen Maßstab. Zu diesem …
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Modulation der Immunogenität von HPV-16 L1/E7 Chimären Virus-ähnlichen Partikeln
High-risk Papillomviren des Menschen (z.B. HPV16) stellen das ätiologische Agens von Gebärmutterhalskrebs (Zervixkarzinom) und dessen Vorstufen dar. Das Zervixkarzinom ist weltweit der dritt häufigsten Krebs bei Frauen. Trotz chirurgischer Entfernung des Tumors und einer anschließenden Kombination …
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THE INTERACTION OF TRANSCRIPTION FACTORS WITH THE LONG CONTROL REGION OF HPV 16
Human papillomavirus type 16 (HPV 16) infects mucosal epithelia and causes neoplastic lesions that may progress towards cancer. A segment of 850 base pairs (bp) of the 7904 bp circular DNA genome of HPV 16 termed the long control region (LCR) does not contain genes but contains the control elements …
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Regulation of Human Papillomavirus Type 16 Late L1 mRNA Splicing
Human papillomaviruses (HPVs) cause almost half of the human cancers that are attributable to viruses. HPV type 16 is the most carcinogenic type among the HPVs and is detected in 50% of all cervical cancers. HPV-16 infects epithelial cells and HPV-16 gene expression is tightly linked to the …
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E7 PROTEINS OF HIGH-RISK (TYPE 16) AND LOW-RISK (TYPE 6) HUMAN PAPILLOMAVIRUSES REGULATE p130 DIFFERENTLY
Human papillomaviruses (HPVs) are one of the most common causes of sexually transmitted disease in the world. HPVs are divided into high-risk (HR) or low-risk (LR) types based on their oncogenic potential. HPVs 16 and 18 are considered HR types and can cause cervical cancer. HPVs 6 and 11 are …
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Development of candidate Human papillomavirus vaccines
… vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of HPV-16 (L1 504) and a mutant (504[ΔA266T]), where the alanine at 266 was mutated to a threonine, were expressed in insect …
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Human Papillomavirus Prevalence in Asymptomatic Men
Introduction: Human papillomavirus (HPV) is the sexually transmitted etiologic agent of cervical cancer. While HPV infects both men and women, little is known about HPV infection in men. Specifically, knowledge of the prevalence of type-specific HPV infection and the distribution of these …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… one of the oncoproteins encoded by high-risk HPVs, due to its ability to degrade tumor suppressor p53, activate telomerase, avoid apoptosis and other functions that contribute to carcinogenesis. Most of the functions of high-risk E6 proteins act through interaction with host cellular proteins, …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… one of the oncoproteins encoded by high-risk HPVs, due to its ability to degrade tumor suppressor p53, activate telomerase, avoid apoptosis and other functions that contribute to carcinogenesis. Most of the functions of high-risk E6 proteins act through interaction with host cellular proteins, …
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Vergleichende Analyse herpesviraler Amplicon-Vektoren am Beispiel von Antigenen des Humanen Papillomvirus-16
… BEISPIEL VON ANTIGENEN DES HUMANEN PAPILLOMVIRUS-16 Amplicon-Vektoren sind aufgrund ihrer (i) enormen Transgenkapazität von bis zu 152 kbp, (ii) ihres breiten Wirtsspektrums und (iii) der hohen Toleranz des natürlichen Wirts Mensch vielversprechende Kandidaten für den Einsatz in der Gentherapie. …
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The roles of DNA(cytosine-5) methyltransferase1 in carcinogenesis related to cellular factors, virus and chemicals
Infection with HPV-16 genomes which is a primary cause of cervical cancer was shown to be targeted in-vivo by CpG methylation. In a clinical study it was discovered that genomic hypomethylation of the LCR and promoter region correlated with carcinogenic progression. The HPV-16 genome could be …
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Real time PCR and fluorescent in situ hybridization in the detection of the physical tsate of human papillomavirus 16 and 18 in paraffin embedded cervical tissue
Human papillomaviruses (HPV) are the etiologic agents of most cervical dysplasia and all cervical carcinoma. Integration of high risk HPV into the human genome is thought to be a critical event in the progression from cervical dysplasia to invasive cervical carcinoma. The ability to use molecular …
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Production and immunogenicity of chimaeric human papillomavirus-like particle vaccines
Human papillomavirus (HPV) infection, specifically with oncogenic types, has been implicated in effectively all cervical cancer cases. Cervical cancer is a global health burden, especially in the developing world. Up to 18 types of HPV are considered oncogenic, of which HPV -16 and -18 cause 70% of …
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Targeting the human papillomavirus for prevention of cervical cancer
Different types of human papillomavirus (HPV) vary in the extent they cause precursor lesions (CIN) and cancer. There are limited long-term efficacy data on HPV testing in primary screening Among 72 cervical cancers in Mozambique, HPV 16 and 18 were the most frequent HPV types (69% of cases). …
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A study of the immune response to human papillomavirus types causing cervical cancer
… the antibody responses to human papillomavirus (HPV) proteins and the association of these responses with cervical disease. Immunoglobulin G (IgG) antibodies to HPV antigens were measured by enzymelinked immunosorbent assay (ELISA) in the serum of children, female blood donors, and patients with …
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Immunogenic assessment of plant-produced Human papillomavirus type 16 chimaeric L1:L2 virus-like particles and the production of an encapsidated therapeutic DNA vaccine candidate
… caused by infection with Human papillomavirus (HPV) is the 4th most common cancer in women globally, and results in an estimated 266 000 deaths every year. Current vaccines are based on the immunodominant L1 major capsid protein, which assembles into virus-like particles (VLPs) that are highly …
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Cellular immune responses to human papillomavirus (HPV) type 16 at the cervix of women with HPV-associated squamous intraepithelial neoplasia
… black South African women. Human papillomavirus (HPV) has been found to be a necessary causative agent of cervical cancer and has been reported to be associated with 84% of cervical intraepithelial neoplasia (CIN). HPV type 16 (HPV-16) is the most prevalent HPV type associated CIN and cervical …
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