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Showing 1 to 15 of 15 for “"HPMCAS"”.
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Investigation of injection moulding for novel drug delivery systems. An investigation into the use of injection moulding to produce pharmaceutical dosage forms and to understand the relationship between materials, processing conditions and performance, in particular drug release and stability
… methyl cellulose acetate succinate (HPMCAS) and a graft co-polymer (Soluplus®). BCS class II drugs ibuprofen and the felodipine were selected based on their physicochemical properties. In the present work, a homogenous dispersion of drugs in the polymer matrices was achieved using Hot …
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DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS
… hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630, were used in spary-dried dispersion (SDD) formulations. Weak acid drugs glipizide and gliclazide which tend to have limited solubility and dissolution rate were chosen as poorly soluble model compounds representing …
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Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics and dissolution kinetics in vitro
… hydroxypropylmethylcellulose acetate succinate (HPMCAS), cellulose acetate suberate (CASub), and 5-carboxypentyl hydroxypropyl cellulose (CHC). Most amorphous solid dispersions reduced rifapentine release at gastric pH, with the best performing polymer CASub showing >31-fold decrease in area …
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Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles
… The polymer of Hypromellose Acetate Succinate (HPMCAS) seemed to best augment the extent of CBZ-SAC and CBZ-CIN cocrystal supersaturation in solution. At 2 mg/ml of HPMCAS concentration, the apparent CBZ solubility of CBZ-SAC and CBZ-CIN cocrystals can increase the solubility of CBZ III in pH …
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Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
… From three different polymers (i.e., EPO, HPMCAS, and S100), the miscibility study indicated the best miscibility of CUR and RES with EPO. From the crystallization kinetics study, we inferred that EPO has a better crystallization inhibition effect than HPMCAS and S100. Finally, interaction …
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Temperature-dependent Terahertz Time-domain Spectroscopy as a Tool to Assess the Crystallisation Tendencies of Amorphous Drug-Polymer Systems
… clotrimazole – were prepared with the polymer HPMCAS across a range of drug loadings and polymer substitution grades. Differential scanning calorimetry (DSC) was used to determine glass transition temperatures, while THz-TDS provided insight into temperature-dependent absorption behaviour. A …
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Amorphous solid dispersion effects on in vitro solution concentrations of quercetin
… hydroxypropylmethylcellulose acetate succinate (HPMCAS) and cellulose acetate suberate (CASub) to achieve stability and provide pH-triggered release. In addition, polyvinylpyrrolidone (PVP) containing CASub and CCAB blends were prepared to further promote enhanced dissolution. The ASD employing …
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Development and manufacture of novel amorphous Itraconazole drug products using quality by design principles
… hydroxypropylmethylcellulose acetate succinate (HPMCAS) and polyvinylacetate (PVA) were screened using group contribution theories developed by Fedors, Van Krevelen and Just-Breitkreutz. The difference in the solubility parameter (Δδ) indicated better miscibility for the ITZ-KOL, ITZ-HPMCAS …
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Predicting the Risk of Crystallization for Suspensions of Amorphous Spray Dried Dispersions from Structural, Thermal and Hydrophilicity Properties
… Hydroxypropylmethyl cellulose acetate succinate (HPMCAS) suspended in 0.5% Methocel + 0.25% sodium lauryl sulfate (SLS) + 5 mM HCl, a platform formulation frequently used in discovery, a 2-tiered model can be used to correctly predict the stability of 22 of 24 model compounds. First, the model …
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A nutritional evaluation and optimisation of infant foods using microencapsulation
… hydroxypropyl methylcellulose acetate succinate (HPMCAS). In the first approach direct spray drying was implemented for the microencapsulation of DHA/HPMCAS organic solutions, while in the second approach solid lipid nano-emulsions of DHA, produced by high pressure homogenization, were …
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Investigation of Amorphous Solid Dispersions of Poorly Water-soluble Drugs in Poly (2-hydroxyethyl Methacrylate) Hydrogels for Enhanced Solubility and Controlled Release
… ASD based on water-soluble polymers (e.g., PVP, HPMCAS) under nonsink dissolution conditions. A subsequent study examines the effect of supersaturation generation rate on the resulting kinetic solubility profiles of amorphous pharmaceuticals and delineates the interplay between dissolution and …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF) successfully postponed the precipitation and maintained the solubility up to 12 hours by forming hydrogen bonds with PTX. This finding was confirmed by FT-IR analysis. </p>
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Design and development of drug delivery systems for immediate and sustained release utilizing hot melt extrusion
… HPC and HPMC), hypermellose ester derivatives (HPMCAS and HPMCP) and acrylic polymer (Eudragit® EPO) with pH dependant solubility were examined for suitability as solubility enhancers for EFZ and processability in melt extrusion processes. To determine suitable polymeric carrier, different tools …
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Mixed Polysaccharide Esters for Amorphous Solid Dispersion Oral Drug Delivery Vehicles
… methyl cellulose acetate succinate (HPMCAS (MF)), even at exceptionally high drug loading ratios of 40 times the concentration of polymer. α-1,3-Glucans are an emerging class of polysaccharides and are structurally different than cellulose due to their α (1→3) linkage versus the …
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Solvent Free Technologies for Polymer based Crystal Engineering and Drug Delivery
… manufacturing with PVP. VA64, HPMCP HP55, HPMCAS, Ethyl cellulose as polymers. In case of cocrystals selected drugs were carabamazepine, caffeine, paracetamol and ibuprofen with co-formers nicotinamide, saccharin, salicylic acid, glutaric acid, oxalic acid, maleic acid. The selections of …