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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"HPMC"”.
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A Study of HPMC-PEG Matrix as Drug Carrier in Spray Congealing
… showed that hydroxypropyl methylcellulose (HPMC) was an appropriate matrix modifier for PEG. The impact of grade and concentration of HPMC on the physicochemical properties of the molten mixtures, drug (metronidazole), PEG matrix and spray congealed microparticles was investigated. Among the …
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Feasibility of AquasolveTM HPMC-AS Lg via Hot-melt Extrusion: Effect of Pressurized CO2 on Physico-mechanical Properties
… to investigate the processability of Aquasolve™ HPMC-AS LG via hot-melt extrusion, and to examine the effect of pressurized carbon dioxide (P-CO2) on the physico-mechanical properties of Efavirenz (EFA)-loaded extrudates (EXT). EFA is as a poorly water-soluble drug and HPMC-AS LG was chosen as a …
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Novel Biomaterials for Applications in Cartilage Tissue Engineering
… versions of hydroxypropyl methylcellulose, or HPMC (named HPMC 2,6 and HPMC triple). These materials were analysed at various concentrations (2%, 3%, 5%, and 7% w/v), as opposed to the conventional approach of using a single concentration, to explore the potential impact of polymer …
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Performance and characteristics of controlled release matrices composed of hydroxpropylmethylcellulose and other polymers.
… the use of hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose (NaCMC) or ethylcellulose, alone or in combination with other adjuncts, to control the release of propranolol hydrochloride from matrices. Gels were characterized by U tube viscometry and their cloud points of …
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A thermal/thermo-mechanical and imaging study of component distribution and interaction in pharmaceutical film coats
… while hydroxypropyl methylcellulose (HPMC) was utilized as the pore forming agent. The thermal, thermo-mechanical and phase distribution of EC films incorporated with plasticizers and/or HPMC were investigated using MTDSC, DMA and localized thermal analysis (LTA). These results were …
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Hydroxypropylmethylcellulose: A New Matrix for Solid-Surface Room-Temperature Phosphorimetry
… investigation of hydroxypropylmethylcellulose (HPMC) as a new solid-surface room-temperature phosphorescence (SSRTP) sample matrix. The high background phosphorescence originating from filter paper substrates can interfere with the detection and quantitation of trace-level analytes. High-purity …
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Materials properties of pharmaceutical formulations for thin-film-tablet continuous manufacturing
… robust, chemical and physical compatible HPMC polymer based films. As well, HPMC polymer based films with no drug loading were compared to measure out the dispersion of the drug on the film. Physiochemical studies were performed by DSC, XRD, FT-IR, and SEM. Moisture content was measured …
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Formulation of novel buccal mucosal drug delivery systems for nicotine replacement therapy (NRT)
Hydroxypropylmethylcellulose (HPMC) and sodium alginate (SA) were used in the formulation of composite wafers and films for potential nicotine (NIC) replacement therapy via the buccal mucosa route. Composite blank (BK), drug loaded (DL) HPMC-SA films (optimized with 2% w/v plasticizer) and wafers …
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Drug release from pellets and matrices based on cellulose ethers.
… coated pellets decreased as the coating load of HPMC increased. However HPMC did not control drug release rate and the majority of both drugs released in less than 1 h. The release exponents for metoclopramide hydrochloride release from HPMC E5 and HPMC E 15 coated pellets were "0.45 and .. 0.40 …
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The use of roller compaction as granulation method for hydrophilic extended release matrix tablets
… method for hydroxypropyl methylcellulose (HPMC) based hydrophilic extended release matrix tablets. Roller compaction is a dry granulation method where powder material is fed through a hopper between two counter-rotating rolls and pressed into a ribbon like compact. The compact is thereafter …
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The effect of precipitation techniques on bioadhesive microparticle characteristics
… was developed for preparing bioadhesive HPMC microparticles for nasal delivery. Aqueous gels of lactose:HPMC (1:1) were used as a model formulation, added to a precipitating solvent, and the effect of processing parameters such as stirring speed (1000-2000 rpm), needle gauge (19g, 21g and …
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Effect of nano- fillers on tensile properties of biopolymer films
… (KGM), hydroxypropyl methylcellulose (HPMC), and zein to investigate their effect on tensile properties of composite films. Tensile properties were measured by dynamic mechanical analysis (DMA) obtaining stress (σ), strain (γ), and Young’s modulus (E). Results revealed significant …
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A method for setup time reduction in high precision machine cells
… was evaluated in a high-precision machine cell (HPMC). Second, the causes and effects of setup problems in an HPMC were identified. Third, a method to reduce setup time was developed to more fully address some of the identified problems. Fourth, the developed method was evaluated in another HPMC. …
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EVALUATION OF HYDROLYTIC ENZYMES IN THE DESIGN OF ORAL DRUG DELIVERY SYSTEMS
… polymer hydroxypropyl methylcellulose (HPMC), a hydrophilic cellulose derivative which is substrate of the enzyme itself. Previous examples of the use of enzymes in drug delivery were investigated through a literature survey, which highlighted their high potential as formulation aids. …
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An investigation into polymeric excipient-drug compatibility in solid-liquid formulations
… polymers hydroxypropylmethylcellulose (HPMC), hydroxyethylcellulose (HEC), carboxymethylcellulose (CMC), gum arabic (GA), guar gum (GG) and lambda-carrageenan (l-carrageenan). The physico-chemical methods developed in this work help improve the current empirical selection of an …
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Amorphous calcium phosphate nanocomplexes in dental film formulations
… films based on hydroxy propyl methyl cellulose (HPMC) of various grades which formed hydrogels with good adhesive properties. The physical properties of the prepared films were characterised by texture analysis, tensile strength and structure and the calcium release was measured using film strips …
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Design of Thermosensitive Hydrogel for Extended-Release of Praziquantel
… was the poloxamer 407 hydrogel adding with HPMC as an adhesive. These hydrogel formulations had a reversible sol-gel transition property at approximate 26 °C and obtained high loading efficiencies and storage stability. <em>in-vitro</em> release studies, as well as <em>in-vivo</em> …
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The use of ATR-FTIR to probe the release mechanism from hydrophilic matrices.
… exipients were used; the hydrophilic matrix HPMC grade K4M, the drug 6-hydroxy buspirone hydrochloride and citric acid. The homogeneity of the formulations were determined by the reproducibility of the spectra obtained from the tablets after compaction and the concentration of exipients …
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Delivery of a Small Hydrophobic and Large Hydrophilic Molecule via Intranasal Route
… DBM was formulated in brain homogenate (BH), in HPMC polymer suspension and as drug-loaded nanoparticles and characterized in solid and suspension states. DBM was loaded into a novel lipid- and cyclodextrin-based nanoparticle formulation and characterized by various methods. In addition, oxytocin …
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Development of Amorphous Ternary Solid Dispersions of a Novel Anti-Tubercular Indole-2-Carboxamide Derivative with Curcumin/Clofazimine for Tuberculosis Treatment
… EPO® (EPO), and hydroxypropyl methylcellulose (HPMC), at 1:1w/w (for binary solid dispersions) and at 1:1:2 w/w/w (for ternary solid dispersions) ratios. The binary and ternary solid dispersions and their respective physical mixtures were characterized for their crystallinity by X-ray …
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