Global ETD Search
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Showing 1 to 16 of 16 for “"HPG axis"”.
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Transcriptomic Profiling of Hypothalamic Kiss1 Neurons
… of the Hypothalamic-Pituitary-Gonadal (HPG) axis. Kisspeptins are crucial for gonadotropin releasing hormone (GnRH) secretion, and subsequently for puberty onset and reproductive function. In mice, two distinct populations of Kiss1 expressing neurons are predominant in areas of the …
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Novel hypothalamic G protein-coupled receptors involved in the control of reproduction
… pathways of the hypothalamus-pituitary-gonadal (HPG) axis. The master hormone regulator of the HPG axis is the gonadotropin-releasing hormone (GnRH). Defects in GnRH neuron activity are associated with reproductive dysfunctions including normosmic congenital hypogonadotropic hypogonadism (nCHH) …
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Prenatal exposure to phthalates accelerates reproductive aging in multiple generations of female mice
… involved in the hypothalamic-pituitary-gonadal (HPG) axis including sex steroids, gonadotropin, and peptide hormones, irregular estrous/menstrual cycles, and together this can lead to infertility. Moreover, the ovary has been shown to exhibit direct signs of aging, including increases in …
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Disrupted female reproductive cyclicity and gonadotropin-releasing hormone neuron dysfunction in a mouse model of temporal lobe epilepsy
… through the hypothalamic-pituitary-gonadal (HPG) axis. At two months post-injection, the effects of epilepsy on the GnRH neuron function are dynamic across the estrous cycle, associated with comorbid estrous cycle disruption severity, and specific to sex. Compared to control mice, the GnRH …
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Biosocial Influences on Toddler Gender-Linked Behavior
… of the hypothalamic-pituitary-gonadal (HPG) axis around 3-months of age is largely unknown. The goal of the present study was to investigate the role of early postnatal activation of the HPG axis in the development of sex differences in human behavior. Participants included 54 children …
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On the neuroendocrine regulation of reproduction: Functional characterization and kinetic studies of the lamprey gonadotropin -releasing hormone receptor and cloning and analysis of the cDNA encoding lamprey gonadotropin-releasing hormone-III
<p>The vertebrate hypothalamic-pituitary-gonadal (HPG) axis is regulated by gonadotropin-releasing hormone (GnRH), a decapeptide that is produced and released from the hypothalamus. At the anterior pituitary, GnRH action is mediated through high affinity binding with the GnRH receptor, a …
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In vitro model of the fathead minnow hypothalamic-pituitary-gonadal axis for toxicological evaluation
… with the hypothalamic-pituitary-gonadal axis (HPG axis). This changes fecundity at the organismal and population level, potentially leading to population crashes. Development of chemicals for agricultural, industrial, and personal use has led to over 80,000 chemicals with unknown …
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Dysregulation in polycystic ovary syndrome: mechanisms and therapeutic approaches
… regulation. The hypothalamic-pituitary-gonadal (HPG) axis plays a key role in reproductive function, controlling the release of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and follicle- stimulating hormone (FSH). Women with PCOS, experience irregular GnRH signaling that leads …
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GATA Like Protein-1: A Somatic Cell Factor Required for Normal Ovarian Development and Function
… albeit without germ cells, and there is loss of HPG axis communication. The loss in HPG communication in Glp-1LacZ null mice can be accounted for by loss of regulated steroidogenesis through the GATA4-dependent transcriptional activation of StAR. These data imply that the somatic cell protein …
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Central and peripheral molecular profiling of sex differences in schizophrenia, major depressive disorder, and controls
… Furthermore, the hypothalamic-pituitary-gonadal (HPG) axis was altered in MDD and first onset, antipsychotic naive schizophrenia patients. Biological processes involving response to steroid hormone stimulus and estradiol were enriched among differentially expressed genes in the PFC in …
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Interactions of GPR54 and GPR147 receptors with RF-amide ligands
… control of the hypothalamic-pituitary-gonadal axis by regulating gonadotropin-releasing hormone secretion. Despite the physiological importance of GPR54/kisspeptin signalling, the GRP54 residues important for receptor activation and signalling have not been extensively investigated. Another …
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Activation of Novel Secretoneurin Circuits in Ovulating Zebrafish
The hypothalamus-pituitary-gonad (HPG) axis is central to vertebrate reproduction. Hypothalamic neurons release the gonadotropin-releasing hormone (Gnrh) which stimulates the synthesis and release of the gonadotropins hormone (Lh) and follicle stimulating hormone (Fsh) in the anterior pituitary. …
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Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
… of hypothalamus-pituitary-gonadal-liver (HPG-L) axis genes in females at all doses, whereas downregulation in males occurred only at higher doses. These results suggest that arsenic acts as an endocrine disruptor and causes more severe reproductive toxicity in females. Chapter 5 assessed …
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Intrinsic Neuronal Plasticity of Kiss1 Neurons in Mice around Puberty
… initiated by the hypothalamic-pituitary-gonadal (HPG) axis, a key hormonal regulatory system in mammals. Gonadotropin-releasing hormone (GnRH) is released from the hypothalamus by GnRH neurons, stimulating the anterior pituitary to secrete luteinizing hormone (LH) and follicle-stimulating hormone …
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NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS
The hypothalamic-pituitary-gonadal (HPG) axis is a conserved neuroendocrine system essential for reproductive function in vertebrates. Central to this axis is the secretion of gonadotropin-releasing hormone (GnRH), a neuropeptide that stimulates the release of gonadotropins from the pituitary, …
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Kisspeptin and neurokinin B in the regulation of the human hypothalamic-pituitary-gonadal axis
… than simply linear in the control of human HPG axis. Manipulation of NKB-KP signalling has therapeutic potential in regulating GnRH/LH secretion in wide range of clinical settings, including contraception, sex-steroid dependent disorders and in the treatment of hot flushes.