Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"HPA axis"”.
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HPA Axis Dysfunction In Treatment Resistant Affective Disorders
… hyperactive HP A (hypothalamo-pituitary-adrenal) axis. The Cortisol Awakening Response (CAR) is a naturalistic measure of the HP A axis activity. Although found to be elevated in depression, it has never been explicitly studied in TRD; furthermore, results have never been compared between …
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Testosterone’s regulation of the HPA axis differs for adolescent and adult male rats
Stress hormones such as corticosterone (CORT), enables rodents to cope and meet the demands of their environment. In adult male rats, CORT release in response to stressors is dampened by the gonadal hormone testosterone. Adolescent male rats secrete more CORT in response to stressors than do adults …
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Modelling altered Glucocorticoid Sensitivity: From HPA axis to metabolic abnormalities in mice and humans
… activity of the hypothalamic-pituitary-adrenal (HPA) axis and cellular activity of 11beta- hydroxysteroid dehydrogenase (11beta-HSD) enzymes that interconvert active 11- hydroxy (corticosterone, cortisol) and inactive 11-keto (11-dehydrocorticosterone, cortisone) glucocorticoids. Here, the …
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Neuroendocrine Consequences of Binge Alcohol Exposure During Peri-Puberty on Functioning of the Hypothalamo-Pituitary-Adrenal (HPA) Axis
… of the hypothalamo-pituitary-adrenal (HPA) axis, a three tiered biological system that mediates physiological stress response. Corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) localized in the paraventricular nucleus (PVN) of the hypothalamus are the major …
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Changes in Hippocampal Plasticity and HPA Axis Function Following Postnatal Exposure to Di(2-Ethylhexyl) Phthalate in Rats
… and whether there is an associated activation of HPA axis. DEHP was injected in juvenile rats daily from PND 16 – PND 22. Brain tissue samples were analyzed by immunohistochemistry to quantify developing neurons. The Golgi – Cox Impregnation method was used for detailed morphological analyses. …
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Maternal HPA Axis Function During Parenting is Associated with Reduced Brain Activation to Infant Cry and More Intrusive Parenting Behavior
<p>Previous research indicated that maternal cortisol function and maternal brain response to infant stimuli are separately related to differences in parenting behavior. Evidence from animal models have demonstrated that chronically high cortisol concentration alters brain structure and function, …
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Circadian activation of the hypothalamic-pituitary-adrenal axis may affect central, but not peripheral, effect of lithium in conditioned taste aversion learning in rats
Activation of the hypothalamic–pituitary–adrenal (HPA) axis has been implicated in conditioned taste aversion (CTA) learning induced by lithium chloride. This study investigated if circadian activation of the HPA axis affects the lithium-induced CTA formation. The pairing of conditioned stimulus …
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The Role of Cortisol In The Cycle of Violence
… function of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA-axis, and its end-product, cortisol, may play a role in regulating aggressive behavior, but this function may be disrupted following abuse and neglect. Another risk factor for aggression, psychopathy, may mediate the cycle of …
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The Intergenerational Transmission of Stress: Investigating Mediators and Moderators of the Association between Maternal Adverse Childhood Experiences and Child Development
… of the maternal hypothalamic-pituitary-adrenal (HPA) axis during pregnancy in transducing the effects of maternal ACEs to child developmental outcomes. A subsequent aim was to evaluate social support as a moderator that may buffer the intergenerational transmission of stress. Methods: Data were …
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Psychoneuroimmunology of Interleukin-10
… can activate the hypothalamic-pituitary-adrenal (HPA) axis. Interleukin-10, as a prominent anti-inflammatory cytokine in the immune system, has been shown to be expressed in both the central nervous system and neuroendocrine system. Little is known, however, about IL-10's functions in the HPA …
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Transcriptome analysis of the hypothalamic-pituitary-adrenal axis in the experimentally domesticated fox
… response, or hypothalamic-pituitary-adrenal (HPA) axis, has been associated with different personality traits and coping styles in humans and animals, while its dysregulation has been implicated in psychological disorders. The molecular basis of HPA axis regulation, however, is not yet well …
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Spatial, temporal, and circuit-specific activation patterns of basolateral amygdala projection neurons during stress
… stress such as hypothalamic-pituitary-adrenal (HPA) axis activation. The overarching aim of this thesis was to conduct a systematic investigation of the spatial, temporal, and circuit-specific activation patterns of basolateral amygdala (BLA) projection neurons during exposure to acute stress. …
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The activity and functioning of the hypothalamic-pituitary-adrenal axis of the red deer stag (cervus elaphus)
The activity and functioning of the HPA axis was investigated in red deer stags under basal and stress induced conditions. In order to overcome the confounding effects of stress inherent in standard methods of blood collection, a portable remote blood sampling device (“DracPac”) was developed and …
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Cognitive, neuroanatomical and neuroendocrine effects of long-term rotating shift work in a nursing sample
… that affect the hypothalamic-pituitary-adrenal (HPA) axis. Whereas acute activation of the HPA axis adaptively activates the body’s stress response by increasing cortisol production, prolonged or repeated activation is detrimental to health due to dysregulation of the HPA axis. Cortisol affects …
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Lifetime stress, blood pressure, heart rate, and salivary cortisol levels in post-menopausal women
… between the hypothalamic-pituitary-adrenal (HPA) axis and the cardiovascular system in these women. Two measures of past stress were examined in relation to BP, HR, and cortisol levels. The Concordia Lifetime Stress Graph (CLSG) provided a measure of lifetime stress, and scores on the Life …
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Spectral Analysis of Complex Dynamical Systems
… in [50]. The Hypothalamic Pituitary Adrenal (HPA) axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body’s cortisol level. Dysregulation of the HPA axis is implicated in numerous stress-related diseases. For a structured model of the HPA axis …
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Alterations of the Corticotropin Releasing Hormone Receptor System Following Early Life Stress and Ethanol Self-Administration in Rhesus Monkeys
… affected hypothalamic-pituitary-adrenal (HPA) axis function and CRH receptor binding. We used an accepted ELS model of maternal separation with nursery-reared (NR) and mother-reared rhesus monkeys induced to self-administer EtOH or control solution for over 12 months. Subjects underwent …
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Regulation of cortisol secretion in humans: relation to vasopressin action at the adrenals in macronodular and micronodular adrenocortical tumours; and well-being in Addison’s Disease.
The hypothalamic-pituitary-adrenal (HPA) axis exhibits tight physiological regulation on a circadian and ultradian basis in humans. Key central regulators include the peptides corticotrophin-releasing hormone (CRH) and arginine vasopressin (VP), acting at the pituitary, and at peripheral structures …
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Epigenetic & transcriptomic alterations associated with childhood maltreatment, major depressive disorder, and post-traumatic stress disorder
… of the hypothalamic-pituitary-adrenal (HPA) axis, a regulator of the body’s stress response, has been associated with exposure to childhood maltreatment, MDD, and PTSD. Additional work has shown that a history of childhood maltreatment, MDD, and PTSD is associated with altered DNA …
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