Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 238 for “"HPA"”.
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HPA Axis Dysfunction In Treatment Resistant Affective Disorders
Background: TRD (Treatment Resistant Depression) patients have been shown to have hypercortisolemia and a hyperactive HP A (hypothalamo-pituitary-adrenal) axis. The Cortisol Awakening Response (CAR) is a naturalistic measure of the HP A axis activity. Although found to be elevated in depression, it …
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How HPA stress response relates to anxiety: Sex differences and estradiol
1 PDF file (viii, 58 pages)
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Testosterone’s regulation of the HPA axis differs for adolescent and adult male rats
Stress hormones such as corticosterone (CORT), enables rodents to cope and meet the demands of their environment. In adult male rats, CORT release in response to stressors is dampened by the gonadal hormone testosterone. Adolescent male rats secrete more CORT in response to stressors than do adults …
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Transgenerational Effects of Synthetic Glucocorticoids on Offspring Behaviour and HPA Development in Guinea Pigs
… alterations in hypothalamic-pituitary-adrenal (HPA) function and stress-associated behaviours in first generation (F1) offspring. Emerging studies in animals determined that sGC results in transmission of HPA and behavioural effects to the next generation (F2) of offspring, but no study has …
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Modelling altered Glucocorticoid Sensitivity: From HPA axis to metabolic abnormalities in mice and humans
… activity of the hypothalamic-pituitary-adrenal (HPA) axis and cellular activity of 11beta- hydroxysteroid dehydrogenase (11beta-HSD) enzymes that interconvert active 11- hydroxy (corticosterone, cortisol) and inactive 11-keto (11-dehydrocorticosterone, cortisone) glucocorticoids. Here, the …
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Neuroendocrine Consequences of Binge Alcohol Exposure During Peri-Puberty on Functioning of the Hypothalamo-Pituitary-Adrenal (HPA) Axis
… of the hypothalamo-pituitary-adrenal (HPA) axis, a three tiered biological system that mediates physiological stress response. Corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) localized in the paraventricular nucleus (PVN) of the hypothalamus are the major …
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Changes in Hippocampal Plasticity and HPA Axis Function Following Postnatal Exposure to Di(2-Ethylhexyl) Phthalate in Rats
… and whether there is an associated activation of HPA axis. DEHP was injected in juvenile rats daily from PND 16 – PND 22. Brain tissue samples were analyzed by immunohistochemistry to quantify developing neurons. The Golgi – Cox Impregnation method was used for detailed morphological analyses. …
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Maternal HPA Axis Function During Parenting is Associated with Reduced Brain Activation to Infant Cry and More Intrusive Parenting Behavior
<p>Previous research indicated that maternal cortisol function and maternal brain response to infant stimuli are separately related to differences in parenting behavior. Evidence from animal models have demonstrated that chronically high cortisol concentration alters brain structure and function, …
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Coping with stress: The Impact of the Hypothalamus Pituitary Adrenal (HPA) System and Neurotrophic Circuits in the Learned Helplessness Model of Depression
… e.g. neurotrophic circuits and the role of the HPA axis, which have to be considered in the pathophysiology of the disease represent a major target of behavioural animal models of depression. Working on a model such as Learned Helplessness, consequently requires careful consideration of …
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Investigations into altered cellular glycosylation associated with metastatic competence in breast cancer cell lines
… and plays a role in metastatic mechanisms. HPA, a lectin from the Roman snail Helix pomatia, recognises glycans terminating in α-GalNAc, and is associated with aggressive biological behaviour, poor patient prognosis and metastasis in breast and other cancers. Three breast cancer cell lines …
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Identification of tumour-associated gycoproteins recognised by the lectin from Helix pomatia in breast cancer
Helix pomatia agglutinin (HPA) is a carbohydrate binding protein isolated from the Roman snail. There has been considerable interest in understanding HPA binding partners in cancer, as the lectin has been shown to identify glycosylation changes in cancers arising from the epithelia, from patients …
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Characterisation of the Helix pomatia agglutinin binding glycoproteins of colorectal cancer cell lines and tissue samples
… The lectin from the Roman snail Helix pomatia (HPA) has attracted interest as tool for the detection of metastatic colorectal cancer but the HPA binding partners have remained poorly characterised. We established an in vitro model using human colorectal cancer cell lines ranging from HPA …
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Circadian activation of the hypothalamic-pituitary-adrenal axis may affect central, but not peripheral, effect of lithium in conditioned taste aversion learning in rats
Activation of the hypothalamic–pituitary–adrenal (HPA) axis has been implicated in conditioned taste aversion (CTA) learning induced by lithium chloride. This study investigated if circadian activation of the HPA axis affects the lithium-induced CTA formation. The pairing of conditioned stimulus …
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Investigating the role of downy mildew effectors in host resistance and susceptibility
… and processes. Hyaloperonospora arabidopsidis (Hpa) is a haustorium-producing biotrophic oomycete pathogen that causes downy mildew on Arabidopsis. Over 100 candidate effectors (called “HaRxLs”), carrying a characteristic RxLR protein motif, have been predicted from the Hpa genome sequence. This …
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The Role of Cortisol In The Cycle of Violence
… function of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA-axis, and its end-product, cortisol, may play a role in regulating aggressive behavior, but this function may be disrupted following abuse and neglect. Another risk factor for aggression, psychopathy, may mediate the cycle of …
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Role of testosterone in mediating prenatel ethanol effects on hypothalamic-pituitary-adrenal activity in male rats
… of the hypothalamic-pituitary-adrenal (HPA) and -gonadal (HPG) axes. E rats show HPA hyperresponsiveness to stressors and altered reproductive function in adulthood. Importantly, prenatal ethanol differentially alters stress responsiveness in adult males and females, raising the …
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Spatial pattern of African Easterly Waves and their Precipitation in Northern Africa
… active in the lower troposphere around 700-850 hPa. This study explores the spatial distribution of AEWs and their precipitation using the Tropical Easterly Waves Climatology and the Integrated Multi-satellite Retrievals for Global Precipitation Measurement (IMERG). First, a spatial filter is …
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Understanding the role of host amino acid transporters in nutrient acquisition by oomycete pathogens
Hyaloperonospora arabidopsidis (Hpa) is a naturally occurring oomycete pathogen on Arabidopsis thaliana. It is related to downy mildews of economically important crops such as cabbage, kale and broccoli, belonging to the Brassicaceae family. Downy mildew pathogens are obligate biotrophs that …
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The Intergenerational Transmission of Stress: Investigating Mediators and Moderators of the Association between Maternal Adverse Childhood Experiences and Child Development
… of the maternal hypothalamic-pituitary-adrenal (HPA) axis during pregnancy in transducing the effects of maternal ACEs to child developmental outcomes. A subsequent aim was to evaluate social support as a moderator that may buffer the intergenerational transmission of stress. Methods: Data were …
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