Global ETD Search
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Showing 1 to 3 of 3 for “"HOXC8"”.
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Role of Non-Coding RNA NC4 in MLL and CYP33 Mediated Regulation of HOXC8
… at the MLL target gene promoters, including the HOXC8 promoter. CYP33 RRM binds Poly A and Poly U RNA in addition to MLL. A regulatory region of MLL target gene HOXC8 is transcribed into a non-coding transcript, which we call NC4 in this study. We hypothesize that the regulation of HOXC8 via MLL …
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MicroRNA targeting in mus musculus and Caenorhabditis elegans
… complementarity to the 3'UTRs of Hoxb8, Hoxc8, and Hoxa7; in particular, miR-1 96 has complete complementarity to Hoxb8 with the exception of a single G:U wobble. In 2004, Yekta et al., were able to detect RNA fragments diagnostic of miR-1 96-directed cleavage of Hoxb8 transcript in mouse …
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An evolutionary perspective on the sequence, mechanism, and regulatory function of animal microRNAs
… demonstrated down-regulation of Hoxb8, Hoxc8, Hoxd8, and Hoxa7 and supported a cleavage mechanism for miR-196-directed repression of Hoxb8. These results point to a miRNA-mediated mechanism for the posttranscriptional restriction of Hox gene expression during vertebrate development and …