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Showing 1 to 12 of 12 for “"HOXA9"”.
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The Mechanisms of HOXA9-mediated Acute Myeloid Leukaemia Maintenance
… through which developmental transcription factor HOXA9 supports the AML maintenance. Beyond its normal roles in embryonic development and maintenance of the haematopoietic progenitor cells, HOXA9 is overexpressed in 50-70% of AMLs, is a harbinger of poor treatment outcomes and is an established …
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The Role and Mechanism of The Homeobox Gene Hoxa9 In The Growth of Epithelial Ovarian Cancer
… environment are poorly understood. <em>HOXA9</em>, a homeobox gene that is normally expressed in the developing female reproductive tract, is aberrantly expressed in EOCs and controls the morphologic features of these tumors. The differentiation pattern of a tumor is an important …
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Modelling timing in blood cancers
… distinct mutation order. My analyses identify HOXA9 as a potential prognosis marker and biological switch responsible for patient stratification in these patients and in Acute Myeloid Leukemia. Additionally, a molecular network identifies the hematopoietic regulators involved in the branching …
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Identifying Genetic Variants and Characterizing Their Role In Clubfoot
… rs3801776 located in the basal promoter of <em>HOXA9</em>, a gene also involved in muscle development and patterning. Altogether, this data suggests that SNPs located in potential regulatory regions of genes involved in muscle development and function could alter transcription factor binding …
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Persistant GATA2 Expression Promotes Self-Renewal of Myeloid Progenitors and Blocks Lymphoid Differentiation.
… of these immortalized lines. Nmyc and HoxA9 mRNA were significantly higher in GATA2-ERT immortalized lines compared to control immortalized lines. Repression of either Nmyc or Hoxa9 in GATA2-ERT immortalized cells impaired their proliferation suggesting that they are potential GATA2 …
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Downregulation of Prdm16 Is Critical for HOXB4-mediated Benign HSC Expansion In Vivo
… markedly repressed by HOXB4 but upregulated by HOXA9 and HOXA10, suggesting that Prdm16 downregulation was involved in preventing leukemia in HOXB4 transplanted mice. Functional evidence to support this mechanism was obtained by enforcing co-expression of sPrdm16 and HOXB4, which led to myeloid …
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Analysis of Variation In Clubfoot Candidate Genes
… rs3801776, located in the basal promoter of <em>HOXA9</em>. Several significant associations were found with SNPs in <em>NFAT2</em> and <em>TNIP2</em>. Significant gene interactions were detected between SNPs in <em>HOX</em> and apoptotic genes. These findings suggest a model for clubfoot in …
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Genetic and Epigenetic Interactions in in vivo and in vitro Reprogramming
… involving HOX genes themselves: e.g. NUP98-HOXA9) and with other disease-initiating translocations: e.g. MLL translocations and inv(16)). However, HOX genes are also highly expressed in many AML samples without translocations; the mechanism that causes "dysregulation" in these cases is …
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
… ability and expression of MLL target genes Hoxa9 and Meis1 compared to MLL-AF9(WT). Coimmunoprecipitation studies show that the D546R mutation in the context of amino acids 376-568 of AF9 significantly reduces binding to Dot1l while maintaining interaction with Af4. These results indicate …
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Optimization and Validation of the Derivation and Use of HoxB8 Transgenic Murine Phagocytes in In Vitro Studies
… a comprehensive tool/resource paper on HoxB8 and HoxA9-mediated immortalization. Further, I compared macrophages derived from HoxB8 conditionally immortalized progenitor cells, bone marrow-derived macrophages, and J774A.1 cells (herein referred to as J774 cells) (commonly used macrophage-like cell …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
… of the leukemic transcription factors, Hoxa9 and Meis1. These findings explain why E2A-PBX1-driven bone marrow transplant models fail to generate B-lymphoid disease and suggest that future efforts in developing a model of E2A-PBX1-driven pre-B ALL leukemia should focus on expressing …
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Significance of Protein Interactions in Mediating AF9 Function
… expression of some MLL target genes such as HOXA9 and MEIS1, and enhanced proliferation of hematopoietic progenitors. MLL chimeras do not retain the histone methyltransferase activity of wild type MLL and it is unclear how they deregulate the expression of MLL target genes.</p><p>AF9 is one …