Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"HOXA5"”.
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Analysis of HOXA5 expression and function in development of the central nervous system
… of the vertebrate body axes. In mouse, Hoxa5 transcripts are differentially expressed in specific mesoderm-derived structures and in the most anterior domain of expression in the central nervous system (CNS). However, the functional significance of any pattern of protein-coding RNAs must …
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Mir-484 Functions As An Onco-Mir In Triple Negative Breast Cancer
… is inversely correlated with levels of <em>HOXA5</em> in patients’ tumors and demonstrated that miR-484 directly binds to the 3¢-untranslated region (3¢-UTR) of <em>HOXA5 </em>mRNA to suppress its expression. Moreover, HOXA5 over-expression recapitulated the effects of miR-484 inhibition. …
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Characterising the MLL complex: epigenetic regulation of Hoxa genes
… largest changes upon differentiation: Hoxa4 and Hoxa5. When active, these genes are associated with a peak of “activating” histone marks (H3K4me3, H3K9ac, H4K16ac) over the transcriptional start site, which are lost when the gene is repressed. This correlated with the recruitment of enzymes that …
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Genetic and Epigenetic Interactions in in vivo and in vitro Reprogramming
… patterns, most AML cases predominantly express HOXA5, A9, A10, B2, B3, and MEIS1 in a canonical, highly coordinated pattern that is virtually identical to that found in normal human CD34 cells. HOX gene "dysregulation" in these cases may therefore represent the persistence of a normal, stem …