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Showing 1 to 3 of 3 for “"HORMA domain"”.

  1. The Meiosis Specific Aaa+ Atpase Pch2 Interacts With The Synaptonemal Complex Protein Hop1 Through The Hop1 Horma Domain

    West, TimothyCornell University2016

    cornell Repository record

  2. Histone H3 K4 Methylation Regulates The Spindle Assembly Checkpoint Through Direct Binding of Multiple Checkpoint Components and Cdc20

    Schibler, Andria C2016

    … (APC) protein Cdc20. <em>MAD2</em> encodes a HORMA domain, which I identify as a novel histone binding motif. Mad2 maintains two differing conformations, closed Mad2 (C-Mad2) and open Mad2 (O-Mad2). We find C-Mad2 increases the Mad2-H3 interaction. In addition, O-Mad2 limits the H3-Mad2 …

    uthsc Repository record

  3. MODELING INFERTILITY: SINGLE GENE MUTATIONS AND CONSEQUENCES FOR GERM CELL DEVELOPMENT

    Chotiner, Jessica2022

    … mouse lines. Trip13 is an ATPase that remodels HORMA-domain proteins and is essential for meiotic progression. Pathogenic mutations of TRIP13 are found in humans and cause infertility via oocyte maturation arrest. In Chapter 2, we used a genetic approach and imaging techniques to study the …

    penn Repository record