Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"HOIP"”.
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An investigation into the role of LUBAC and linear ubiquitin chains in antibody dependent intracellular neutralisation
… adenovirus neutralisation model. I found that HOIP, the only E3 ubiquitin ligase capable of generating linear ubiquitin chains, is required for efficient neutralisation of adenovirus by TRIM21. Using a small molecule inhibitor of HOIP, I found that its E3 ligase ability is required for its …
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Investigation into ubiquitin signalling in response to cisplatin
… study of the roles of novel hits RNF113B, HOIP and ABIN1 in the DNA damage response. <br/>RNF113B was a previously uncharacterized E3 ligase. Studies described herein initially suggested that RNF113B might have a role in DNA repair after cisplatin treatment. However, final validation of a …
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Towards Glasses from Two-Dimensional Hybrid Organic–Inorganic Perovskites
Hybrid organic-inorganic perovskites (HOIPs) are an emerging class of functional materials with exceptional potential in optoelectronics. While research has long focused on their crystalline states, recent discoveries have revealed that certain HOIPs can melt, and be quenched into frozen liquids, …
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LUBAC is required for the RIG-I mediated antiviral response
… by the tripartite E3 ligase LUBAC, made up of HOIP, HOIL and SHARPIN, and are required for NF-κB activation by PRR such as TLR3 and MDA5 signalling. Here we show that the catalytic component HOIP, and HOIL-1, are required for activation of both IRF3 and NF-κB-dependent antiviral signalling …
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… substrate interaction of IpaH1.4/2/5 and HOIP was previously characterized. I went on to identify that IpaH2.5 is able to inhibit the in vitro catalytic activity of HOIP via mono-ubiquitination of catalytic lysine residues in the HOIP ring-between-ring domain (RBR-C). Subsequent to this …
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… which consists of another E3 ubiquitin ligase, HOIP, and SHARPIN. The LUBAC has been shown to be a major regulator fo multiple immune-related responses by conjugating linear ubiquitin chains to multiple target proteins, with HOIP functioning as the major catalytic subunit for linear …
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Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARI
… Most well known RBRs include Parkin and HOIP, which are associated with Parkinson’s disease and innate immune deficiency. However, it is not well known how the RBR proteins gain activity, as they are known to be autoinhibited. Here I show that a specific F430A, E431A, E503A triple …
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Analyzing Functional Interactions of Designed Peptides by NMR Spectroscopy
… designed to mimic the spatial structure of the HOIP-NZF1 domain interacting with the NEMO CC2-LZ domain to suppress the NF-kappaB activation. The structure elucidation of the designed peptide provided vital information about matching the required pharmacophore structure in the peptide.</p>
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Nonlinear Processes in Room Temperature Exciton-Polaritons
… the 2D hybrid organic-inorganic perovskite (HOIP) offers the added advantage of room temperature investigations owing to their large exciton binding energy. In this work, we strongly couple excitons in 2D HOIP crystals to planar microcavity photons sustaining exciton-polaritons under ambient …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
… IpaH1.4 specifically binds the LUBAC component HOIP and mediates its proteasomal degradation, thus abolishing linear ubiquitylation of bacteria and consecutive NF-κB activation via NEMO and autophagy induction via optineurin. Lastly, I identified novel potential ubiquitylation targets for IpaH …
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
… by ubiquitin and by the individual subunits (HOIP, HOIL-1, and Sharpin) of the linear-ubiquitin assembly complex (LUBAC). Autophagy cargo receptors, such as NDP52, p62, and Optineurin, are also recruited to the type II, intracellular parasites. Although all these recruitments were …