Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"HNSCC"”.
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Abelson Kinase Based Regulation of Tumor Cell Invasion in HNSCC
… cases of head and neck squamous cell carcinoma (HNSCC) are annually diagnosed in the United States. The current standard of care for HNSCC patients consists of chemoradiation often combined with targeted therapeutic agents. However, the five-year survival rate for patients that relapse is < 50%. …
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Signal Transduction Effects Induced by Erythropoietin in a HNSCC Model System
Head and Neck Squamous Cell Carcinoma (HNSCC) is an epithelial skin cancer of the upper aerodigestive tract, and is the sixth most common malignancy in the U.S. HNSCC patients undergoing chemotherapy commonly develop anemia, a condition in which the body lacks mature red blood cells (RBCs). …
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Effects of CXCL8 Overexpression on Tumor Cell Proliferation and Migration in an HNSCC Cell Model
Head and neck squamous cell carcinoma is the 6th most common malignancyworldwide. Recently, a link between cancer and inflammation has been found. Mediatingthis relationship are the chemotactic cytokines known as chemokines. CXCL8 (Interleukin-8), a CXC ELR+ Chemokine mainly responsible for …
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Vitamin D- induced down regulation of RAD51 in head and neck squamous cell carcinoma (HNSCC), In Vitro and In Vivo
… that head and neck squamous cell carcinoma (HNSCC) responds to VD<sub>3</sub>. This thesis used both in vivo and in vitro models to examine the effect of VD<sub>3</sub> in HNSCC. Former work in the Albala laboratory showed that hamsters that received systemic VD<sub>3</sub> and topical …
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Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head and Neck Squamous Cell Carcinoma
… of head and neck squamous cell carcinoma (HNSCC), provides clinical benefits in just a subset of patients. This together with the lack of biomarkers predicting therapeutic responses, have led to unacceptably high rate of treatment failures in HNSCC. TP53 is the most frequently mutated gene …
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Characterization of Notch1 and Pi3K-Pten-Akt/Mtor Pathway Interaction In Head and Neck Squamous Cell Carcinoma
<p>Head and neck squamous cell carcinoma (HNSCC) affects various mucosal sites of the upper aerodigestive tract, including the nasal and oral cavities, the nasopharynx, and the oropharynx. More than five hundred thousand new cases of HNSCC occurred in 2011 alone, with 50,000 reported cases in the …
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Targeted Differentiation of Primary Head and Neck Squamous Cell Carcinoma Cells
Head and neck squamous cell carcinoma (HNSCC) is a malignant disease; it is the fourth most common cancer in Germany and the sixth most common cancer worldwide, with high fatality rates that have remained essentially unchanged for many years. Especially in the subtype that is negative for human …
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Investigating the effects of EZH2 inhibitors on targeting epigenetic changes in head and neck squamous cell carcinoma
… Head and neck squamous cell carcinoma (HNSCC) affect both men and women worldwide with approximately 880,000 new cases annually. The main risk factors involved in the pathogenesis of HNSCC include smoking tobacco, alcohol consumption and infection with human papillomavirus (HPV). There …
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Age-associated alterations in head and neck cancer
Head and neck squamous cell carcinomas (HNSCC) are the seventh most common cancers globally and have poor survival rates. Current first-line treatments for HNSCC, which include surgical resection and radiotherapy, result in high post-treatment morbidity while alternative treatment modalities, such …
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An Investigation of Epigenetic Mechanisms Driving The Biology of Head and Neck Squamous Cell Carcinoma
<p>Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and is associated with significant morbidity and mortality. To date, the majority of work in the field has focused on genomic alterations such as mutations and copy number alterations. However, the clinical …
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Prognostic biomarkers for head and neck squamous carcinoma
… of head and neck squamous cell carcinoma (HNSCC) to novel and conventional therapies. This has been conducted using two different approaches: The first was to test the sensitivity of HNSCC cell lines to two novel anticancer therapeutic agents, TRAIL and Smac mimetics, and further to …
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Identification and Characterization of Determinants of Head and Neck Tumor Cell Invasion
<p>Head and neck squamous cell carcinoma (HNSCC) is a common malignant disease with poor prognosis. The majority of patients die from local invasion or lymphatic metastasis. The mechanism(s) underlining the invasiveness of HNSCC are poorly understood. Utilizing a panel of HNSCC cell lines …
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Assessing the effects of radiotherapy on head and neck squamous cell carcinoma using microfluidic techniques
… aim of this study was to investigate how HNSCC tissue biopsies maintained in a pseudo in vivo environment within a bespoke microfluidic device, respond to radiation treatment.Materials and Methods35 patients with HNSCC were recruited; in addition liver tissue from 5 Wistar rats was used. A …
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The Tumor Suppressor Notch Inhibits Head and Neck Squamous Cell Carcinoma (Hnscc) Tumor Growth and Progression By Modulating Proto-Oncogenes Axl and Ctnnal1 (Α-Catulin)
… Head and Neck Squamous Cell Carcinoma (HNSCC) is the sixth most common malignancy worldwide, with roughly 300,000 cancer related deaths occurring globally each year. The survival of patients with HNSCC has not changed significantly over the past decade, leading investigators to search …
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Characterization of Jak, Stat, and Src Interactions In Head and Neck Squamous Cell Carcinoma
… of Head and Neck Squamous Cell Carcinoma (HNSCC) is common; thus, it is essential to improve the effectiveness and reduce toxicity of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has roles in …
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Genetic analysis of squamous cell carcinoma of the head and neck
Head and neck squamous cell carcinoma (HNSCC) is the sixth commonest cancer worldwide with an increasing incidence in developing countries. Despite numerous advances in surgery, radiotherapy and chemotherapy over the past few decades the overall survival rate for patients with HNSCC has changed …
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THREE DIMENSIONAL IN VITRO MODEL OF HEAD AND NECK SQUAMOUS CELL CARCINOMA
Head and neck squamous cell carcinomas (HNSCC) are among the leading causes of cancer related deaths throughout the world. The survival rate for this type of cancer is extremely low and has not changed significantly in recent decades. There is an imperative need to study tumor progression in a …
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Induced Cytotoxicity In Crebbp/Ep300Mut Head and Neck Squamous Cell Carcinoma
… Head and neck squamous cell carcinoma HNSCC is the most common malignancy in the head and neck. Most cases are found in advanced stages and depending on the location can be treated with surgical resection and/or radiation (XRT), chemotherapy, or chemoradiation. Our lab groups have …
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Epigallocatechin-3-gallate and tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer : Involvement of NSAID activated gene-1
… rate, head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in men. The 5-year overall survival rate for patients with advanced HNSCC is around 30%, which is essentially unchanged from the rate recorded two decades ago in spite of various treatment trials. Therefore, …
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Investigating the Mechanisms and Kinetics of Circulating Tumour DNA Release to Improve its Clinical Utility
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with distinct subtypes, molecular features and clinical behaviours. Significant advances to better define this heterogeneity have revealed new targets and attempted to stratify patients into clinically meaningful groups. Human …
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