Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"HNF4α"”.
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Lineage tracing of Ascl1-expressing cells in the maternal liver during pregnancy
… of D18 maternal livers. Furthermore, LacZ and HNF4α co-staining of D13 and D18 maternal livers shows the presence of two populations of LacZ-expressing cells: HNF4α+ population and HNF4α- population. HNF4α+ LacZ-expressing cells represent hepatocyte lineage cells that are derived from …
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P53 Maintains Hepatic Cell Identity During Liver Regeneration
… master regulator of hepatocyte differentiation, HNF4α, to induce 78% of these genes, including a number of liver-enriched transcription factors such as CCAAT/enhancer binding protein beta (CEBPβ), hepatocyte nuclear factor 6 alpha (HNF6α), hepatocyte nuclear factor 6 beta (HNF6β). Thus, p53 acts …
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O-GlcNAcylation: A key regulator of hepatic proliferation and differentiation
… RNA-Seq studies revealed the inactivation of HNF4α, a known termination signal and master regulator of hepatic differentiation, in OGT-KO mice 28 days after PHX. This lack of hepatocyte differentiation was confirmed by a significant decrease in HNFα target genes in OGT-KO mice. …
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Role of ATRX in colorectal cancer metastasis
… chromatin accessibility and transcription factor HNF4α activity at colonic epithelial gene loci. Furthermore, I show that TWIST1 function is required for phenotypic and transcriptional EMT in response to TGFβ. Strikingly, loss of TWIST1 function further enhances metastatic ability of the ATRX …
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Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment
… expression of MUC4 and its transcription factor HNF4α. The combined treatment of apicidin and gemcitabine synergistically inhibited growth of Capan-1 cells (VI).
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Neutrophil Regulation of Colitis
The delicate intestinal homeostasis is regulated by interactions between microbiota, intestinal epithelial cells (IECs), and the intestinal immune system. As a crucial component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial …