Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"HNF1B"”.
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The use of human pluripotent stem cells to model HNF1B-associated diabetes
… factor, hepatocyte nuclear factor 1B (HNF1B), result in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms that underlie development of diabetes in HNF1B mutation carriers are still not fully understood due to lack of …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
… are highly expressed in RCC. This highlighted HNF1B as a potential tumour dependency in ccRCC. I demonstrated that both HNF1B CRISPR knockout and CRISPRi knockdown conferred a strong selective disadvantage in vitro that was rescued by HNF1B restoration, suggesting that it was a specific effect …
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Functional characterisation of driver events in ovarian clear cell carcinoma
… cancer. Putative driver genomic events include HNF1B overexpression and inactivating ARID1A mutations. Importantly, these can also be found in a significant proportion of adjacent non-malignant endometriotic lesions and, therefore, are likely early events in OCCC pathogenesis. I hypothesised …
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Modelling human liver bud development in vitro
… pancreato-biliary progenitors (KRT19+CDX2+PDX1+HNF1B+) and extra-hepatic cholangiocytes (ACE2+MUC13+). By performing extensive snRNAseq analyses across HepBud formation, I was able to validate that hepatic specification in HepBuds follows a natural developmental path forming hepatoblast which …