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Showing 1 to 20 of 23 for “"HNE"”.
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Species-specific Myoglobin Oxidation
<p>4-Hydroxy-2-nonenal (HNE) is a reactive secondary lipid oxidation product present in meat products. Oxymyoglobin (OxyMb) oxidation is accelerated by HNE adduction. The adduction of HNE to the histidine (His) residues of OxyMb is believed to alter the tertiary structure of OxyMb and make the heme …
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Temperature Dependence of 4-Hydroxy-2-Trans-Nonenal (HNE), a Toxic Aldehyde, in Coconut, Palm, Safflower and Grape Seed Oils
… of the formation of 4-hydroxy-2-trans-nonenal (HNE), the most toxic aldehyde among the four α, β-unsaturated-4- hydroxyaldehydes, was investigated in commercial coconut, palm, safflower and grape seed oils. These oils were heat treated at different temperatures (165, 185 and 218°C) for different …
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Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
4-hydroxy-2-nonenal (HNE) is one of the most reactive aldehydes produced during lipid peroxidation (LPO) and has been demonstrated to have cytotoxic and genotoxic effects. Several oxidoreductases (ORs) have been reported to detoxify HNE including aldehyde dehydrogenase (ALDH) and aldo-keto …
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Ribonucleotide reductase in dividing cells: Purification and inhibition studies with 4-hydroxynonenal
… the lipid peroxidation product 4-hydroxynonenal (HNE) on CDP reductase from juvenile normal rat liver was investigated. HNE inhibited the CDP reductase activity. The inhibition was dependent on the concentration of HNE and the incubation time. The enzyme activity was reduced 500/0 by 0.1 roM HNE. …
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The role of 4-hydroxynonenal in cellular signaling mechanisms
… level of LPO product 4-hydroxynonenal (HNE) is necessary for maintaining key proliferation, adhesion, and survival signaling by regulating expression of genes involved in these pathways, and that alteration of that level either up or down will result in induction of genes pro-apoptotic …
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Free radical mediated mechanisms in stress and development in in vitro crop plant systems
… lipid peroxidation products hydroxynonenal (HNE) and malondialdehyde (MDA) inhibit callus proliferation and development (as somatic embryogenesis). Removal of the aldehydes led to a reversal of inhibitory effects.<br/><br/>For the first time, HNE and MDA were measured in extracts of callus …
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Identification and Quantification of Protein Carbonylation by Mass Spectrometry
… acrolein (ACR) and 4-hydroxy-2-nonenal (HNE). The investigation is focused on the characterization and quantification ACR and HNE addition to the model proteins. A correlation between HNE modification and ACO activity is also determined. These results provide insights into the impact of …
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Effects of Acute Heat and Oxidative Stress on the Hepatic Expression of Orexin and Its Related Receptors
… hydrogen peroxide (H2O2) and 4-hydroxynonenal (4-HNE) on the hepatic expression of ORX and ORXR1/2 in the avian species. Overall, heat stress significantly down regulated the expression of ORX, and ORXR1/2 mRNA and pro1tein in quail liver and LMH cells. LMH cells treated with H2O2 had decreased …
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The synthesis and evaluation of valine mimic protio and halo enol lactones as human neutrophil elastase inhibitors
Human neutrophil elastase (HNE) has been found to be responsible for the destruction of lung tissue in emphysema. Based on the primary substrate selectivity of HNE, a series of valine mimic protio and bromo enol lactones were designed as HNE inhibitors. General methods were developed for the …
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SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES
… that can release a biocidic aldehyde, 4-HNE, upon photolysis, has been studied as a possible alternative to overcome this limitation of photodynamic therapy at present. The impact of variations in substitution, conditions and additives on the course of the mechanistic pathways involved in …
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Bioengineering the Expression of Active Recombinant Human Cathepsin G, Enteropeptidase, Neutrophil Elastase, and C-Reactive Protein in Yeast
… G (hCatG) and human neutrophil elastase (HNE) were expressed in P. pastoris and HNE was also expressed in K. lactis. The recombinant variants rhCatG and rHNE, with intact C-terminal extensions, were expressed as fusion proteins with the soluble heme-binding domain of cytochrome B5 (CytB5) …
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Studies on polyunsaturated fatty acid content and lipid peroxidation in preterm infant nutrition from non-maternal sources.
… of LPPs (malondialdehyde, 4-hydroxy-2-nonenal HNE, hexanal), with the highest levels seen in DHM (23.5 ± 6.3 µM TBARS; 60.0 ± 75.1 µg/mL HNE). No detrimental effects of LPPs at levels expected in FM were detected in a preliminary in vitro model. However, as DHM and preterm FM may be the only …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… an IHC staining for 4-hydroxynonenal (4-HNE) in addition to a malondialdehyde (MDA) colorimetric assay was performed. IHC staining for Caspase-3 was conducted to assess apoptosis. Finally, the effects of 20-HETE inhibition on the ferroptosis pathway were examined by measuring the mRNA and …
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Phytochemische und Pharmakologisch-biologische Untersuchung von traditionellen Heilpflanzen aus Costa Rica sowie Bindungs- und QSAR-Studien mit der Humanen Neutrophilen Elastase und dem Transkriptionsfaktor NF-kB als molekularen Targets
… für die Bindung an das aktive Zentrum von HNE wichtig sind. Bei Zimtsäurederivaten ist das Vorhandensein einer aromatischen o-Dihydroxygruppe zusammen mit einer lipophilen Struktur wichtig für die Aktivität. Sie bilden ein H-brückennetzwerk mit der katalytischen Triade aus. 8 SLs hemmen die …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
… to oxidative stress induced by 4-hydroxynonenal (HNE) in a ligand-independent mechanism. Furthermore, cleavage of the receptor was demonstrated to contribute to the death of sympathetic neurons following oxidative insult. This study investigates the effects of oxidative stress on p75NTR signaling …
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… Apocynin was found to reduce expression of 4-HNE, a lipid peroxidation product, in chronic SCI rats when administered intraperitoneally 30 minutes before perfusion and fixation. Evoked and non-evoked measures of neuropathic pain were reduced in chronic SCI rats when Apocynin was applied …
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The maculoprotective effect of a thiol antioxidant in retinal degeneration models
… (as measured by formation of 4-hydroxynonenal, 4-HNE), elevated cysteine levels, and death of photoreceptors resulting in outer nuclear layer thinning. NACA eye drops reversed these toxic effects. In conclusion, this potent antioxidant should continue to be investigated as a treatment for …
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Assessing fetal topoisomerase IIα as a mechanism of in utero benzene toxicity in generating double-stranded DNA damage in CD-1 mice
… cells and increases 4-hydroxynonenal (4-HNE). Levels of γH2AX, a marker of dsDNA breaks are also increased in fetal liver cell culture following 12.5 µM BQ exposure. Next, using an in vivo CD-1 mouse model of transplacental benzene carcinogenesis which previously showed that 200 mg/kg IP …
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Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation
… revealed extensive 4-hydroxy-2-trans-nonenal (4-HNE) modification of cathepsin B in UVA-exposed fibroblasts. Consistent with lysosomal impairment, accumulation of cellular autofluorescent material colocalizing with lysosomes was observed by confocal fluorescence microscopy, and extensive …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
… by a reduction in GPX4 and an increase in 4-HNE. The use of antioxidants (TEMPOL, ferrostatin-1, and hydroxyurea) and iron chelators (deferiprone and, potentially, hydroxyurea) were able to ameliorate renal iron accumulation, oxidative stress, lipid peroxidation, and rhabdomyolysis-induced …
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