Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"HML-2"”.
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… to accurately quantify levels of HERV-K (HML-2) gag expression, relative to normalised levels of housekeeping gene expression. Both serological and molecular assays showed significant increases in HERV-K (HML-2) activity in RA patients compared to disease controls with CD4+ lymphocytes …
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Insertionally polymorphic human endogenous retroviruses and their potential role in cancer
… a family of endogenous retroviruses, HERV-K(HML-2) was investigated. The family is the youngest endogenous retrovirus family known in humans, with some of its members being insertionally polymorphic in modern human populations. There have been numerous reports of HERV-K(HML-2) members being …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… kept full-intact open reading frames. HERV-K (HML-2) is transcriptionally active in many cancer tissues and tumour cell lines, and several studies have highlighted its role in cancer. Preliminary data showed overall HERV-K upregulation in Merlin-deficient schwannoma, and thus this project aims …
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Aktivität endogener Retroviren in Tumorgeweben von Primaten
… Expression einzelner Mitglieder der HERV-K (HML-6) mehrfach beobachtet werden. Diese Arbeit befasst sich mit der Entwicklung eines Systems zur Amplifikation HML-6 spezifischer LTR-Regionen mittels 5´-RACE PCR, die eine Analyse differenziell exprimierter Transkripte in Melanomzellen erlaubt. …
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Reconstitution and Characterization of Human Endogenous Retrovirus-K
… However, one family of Class II HERV, HERV-K(HML-2), seems to have been replicating until recently. The HERV-K(HML-2) family includes human specific members and elements that are polymorphic in the human population, suggesting replication since the divergence of humans from chimpanzees 6 …
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Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
… as Amyotrophic Lateral Sclerosis. While HERV-K (HML-2) transcripts were reported as elevated in premotor cortex samples from an ALS American cohort by Li et.al. (2015) the RT-qPCR assays performed in this sudy, using the same primers and reaction conditions in a larger ALS UK cohort were unable …