Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"HML"”.
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Characterization of the human endogenous retrovirus HERV-‐K(HML-‐6) and HERV-‐K(HML-‐10) sequences and analysis of their expression
… studied HERVs is the betaretrovirus HERV--‐K(HML1--‐10) clade, composed of 10 groups whose correlation with diseases has been proposed in a number of cases. In particular, it has been reported that the env gene, termed HERV--‐K--‐MEL, is expressed in melanoma cells and not in healthy controls. …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
… to accurately quantify levels of HERV-K (HML-2) gag expression, relative to normalised levels of housekeeping gene expression. Both serological and molecular assays showed significant increases in HERV-K (HML-2) activity in RA patients compared to disease controls with CD4+ lymphocytes …
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Instructional requirements for using the HML and NRR methods for estimating protected exposure levels under hearing protectors
… C-weighted sound levels, and using the NRR and HML methods. Three instructional tools were evaluated: 1) outline instructions, 2) tabular nomogram, and 3) hypermedia computer-based instructions. Effectiveness was measured in terms of calculation time and proportion of errors made. The results …
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HML, SMB, and GDP: Do Fama and French Factors Contain Information for Future Domestic Product in the United States?
This study examines whether the abnormal returns of zero investment strategies selected by book-to-market values and market capitalization exhibit correlations to future real Gross Domestic Product (GDP) growth in the United States. Using the factor returns from 1993 to 2012 contrasting against …
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Aktivität endogener Retroviren in Tumorgeweben von Primaten
… Expression einzelner Mitglieder der HERV-K (HML-6) mehrfach beobachtet werden. Diese Arbeit befasst sich mit der Entwicklung eines Systems zur Amplifikation HML-6 spezifischer LTR-Regionen mittels 5´-RACE PCR, die eine Analyse differenziell exprimierter Transkripte in Melanomzellen erlaubt. …
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Insertionally polymorphic human endogenous retroviruses and their potential role in cancer
… a family of endogenous retroviruses, HERV-K(HML-2) was investigated. The family is the youngest endogenous retrovirus family known in humans, with some of its members being insertionally polymorphic in modern human populations. There have been numerous reports of HERV-K(HML-2) members being …
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Molecular and Genetic Characterization of SAS Genes in Position Effect Silencing in Saccharomyces Cerevisiae
… SAS4 and SAS5 contribute to silencing at HML. Double mutant analysis of silencing at HML between SAS4, SAS5 and SIR1 suggests that SAS4 and SAS5 may have similar function as SIR1 acting in establishment of silencing. Taken together, these evidence demonstrates that there exist multiple …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… kept full-intact open reading frames. HERV-K (HML-2) is transcriptionally active in many cancer tissues and tumour cell lines, and several studies have highlighted its role in cancer. Preliminary data showed overall HERV-K upregulation in Merlin-deficient schwannoma, and thus this project aims …
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Neural and endocrine control of mating behavior in selected mating lines of chickens and quail
… and quail genetically selected for high (HML) and low (LML) cumulative number of completed matings (CNCM). In the initial experiment, discrete bilateral lesions were stereotaxically placed in the ruber nuclei of LML cocks. Contrary to published results, the LML cocks did not demonstrate an …
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Effects of Cadmium on Calcium homeostasis and physiological conditions of the freshwater Mussel Anodonta anatina
… types of samples were taken. Hemolymph (HML), extrapallial fluid (EPF), gills, mantle, digestive gland, kidney and other tissues were used to determine total Cd, the 114Cd/111Cd isotope ratio for studying Cd accumulation, distribution, elimination and redistribution of background Cd, and …
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Reconstitution and Characterization of Human Endogenous Retrovirus-K
… However, one family of Class II HERV, HERV-K(HML-2), seems to have been replicating until recently. The HERV-K(HML-2) family includes human specific members and elements that are polymorphic in the human population, suggesting replication since the divergence of humans from chimpanzees 6 …
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Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
… as Amyotrophic Lateral Sclerosis. While HERV-K (HML-2) transcripts were reported as elevated in premotor cortex samples from an ALS American cohort by Li et.al. (2015) the RT-qPCR assays performed in this sudy, using the same primers and reaction conditions in a larger ALS UK cohort were unable …
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Clinical Significance of Homologous Recombination Deficiency Score Testing In Endometrial Cancer
… instability (MSI) and high mutation load (HML) using a next generation sequencing assay targeting the coding regions of 43 genes and 54,091 genome wide single nucleotide polymorphisms (SNPs) developed by Myriad Genetics. The HRD score is the sum of three previously described scores (loss of …
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Hierarchical multi-label classification for protein function prediction going beyond traditional approaches
… <p>algorithm using Boosting classifiers, HML-Boosting, for the hierarchical multi-label</p> <p>classification problem in the context of gene function prediction is proposed. HML-Boosting exploits the predefined hierarchical dependencies among the classes. We demonstrate, through …
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From Fossils to Function: Exploring the Evolutionary And Functional Diversity Of HERV Envelope Proteins Across Primate Lineages
… first part of the project focused on the HERVK(HML2) group, which is significant due to its recent integration into the human genome and its functional conservation. While ERVs are found in all vertebrates, HERV-K is specific to primates and includes 10 HML subtypes, with HML2 being the youngest …
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The cost of equity capital for REITs : an examination of three asset-pricing models
… by Fama and French, SMB (small minus big) and HML (high minus low). In the third model, two additional macroeconomic factors are included to represent the change in expected inflation and the change in risk premium. Using factors that are of a pervasive macroeconomic nature is in line with the …
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Essays on predictability of stock returns
… modified state space approach to the HML portfolio, I build a novel forecaster for the value premium. Consistent with rational theories of the value premium, the expected value premium is time-varying and countercyclical. In the third chapter, based on the joint work with Igor Makarov, …
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Robust learning of probabilistic hybrid models
… are the focus of this thesis. We present the HML-LPHA algorithm that uses approximate EM for learning maximum likelihood model parameters of LPHA, given a sequence of control inputs {u}0T, and outputs, {y}T+I 1 We implement the algorithm in a scenario that simulates the mechanical wheel …
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A nutriceutical approach to inhibiting H1N1 influenza infection
… component of infant formula and human milk (HML), and perhaps other natural products are worthy of further exploration as a source of antiviral nutriceuticals. The use of such nutriceuticals, either alone or in combination with other bioactive natural products such as HMO, for the possible …
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ESSAYS ON EMPIRICAL ASSET PRICING USING BAYESIAN METHODS
… that the famous Fama and French (1993, 1996) HML factor has high posterior probability only if portfolios formed on book-to-market ratio are used.
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