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Showing 1 to 13 of 13 for “"HMGR"”.
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Functional analyses of tomato 3-hydroxy-3-methylglutaryl coenzyme a reductase (HMGR) genes in transgenic plants engineered for altered HMGR expression
3-Hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34) mediates the first regulatory step (HMG-CoA reduction to mevalonate) in isoprenoid biosynthesis. The tomato genome contains at least four differentially regulated hmg isogenes encoding HMGR. Functions of tomato hmg2 in defense responses …
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Expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase in maize as influenced by light and bleaching herbicides
… 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, EC 1.1.1.34) is highly expressed in 4-day-old etiolated seedlings of normal ('DeKalb XL72AA'), dwarf (<u>d₅</u>), and albino (<u>lw₃</u>) maize (<u>Zea mays</u> L.). HMGR activity of maize seedlings appeared to be exclusively associated with …
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Molecular cloning, characterization, and expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from tomato
… 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR, EC 1.1.1.34) is a key enzyme regulating biosynthesis of phytosterols, plant growth regulators, carotenoids, antimicrobial defense compounds, and numerous other isoprenoids. To initiate molecular studies of HMGR in relation to defense responses …
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Design, Synthesis, And Evaluation Of Molecular Inhibitors For Biologically Relevant Enzymes
… of molecules for the inhibition of the Class II HMGR enzyme. The work on this subject involved the de novo design and in silico screening of a set of phenothiazine molecules for the inhibition of II-HMGR. These molecules were synthesized and assayed against II-HMGR, resulting in the …
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Membrane Domain of Plant 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: Targeting, Topology, and Function
… by 3-hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34). In plants, HMGR is encoded by small gene families whose members are differentially expressed. In tomato, hmg2 was previously isolated and sequenced. We report the isolation and sequence analysis of a clone (pCD4) encompassing …
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Understanding and Harnessing the Structural Features that Govern HMG-CoA Reductase Activity
… 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR), which catalyzes the reduction of HMG-CoA to mevalonate using two equivalents of the cofactor NAD(P)H, is part of the mevalonate pathway, found in all kingdoms of life. This pathway is at the heart of natural product biosynthesis constituting …
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Role of Subcellular Differentiation in Plant Disease Resistance
3-Hydroxy-3-methylglutaryl CoA reductase (HMGR, EC 1.1.1.34) catalyzes the reaction from hydroxymethylglutaryl CoA to mevalonate in the isoprenoid pathway. In solanaceous plants, one class of endproducts of the pathway are sesquiterpenoid phytoalexins, antibiotic compounds produced by plants in …
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Gene regulation in a pathogen-plant interaction: soft rot erwinias versus potato tubers
… 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), key genes in the biosynthesis of phenylpropanoid- and terpenoidderived compounds believed to be important in plant defenses. Ecc inoculation caused much more rapid and greater increases in PAL mRNA and enzyme activity levels in potato tuber …
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Soybean mosaic virus-soybean interactions: molecular, biochemical, physiological, and immunological analysis of resistance responses of soybean to soybean mosaic virus
… coenzyme A reductase (HMGR)-specific primer sets by polymerase chain reaction. Amplified cDNAs were cloned into Bluescript vector (pKS⁻), transformed into E. coli, isolated pSOY HMGR and used as a probe for Northern analysis. We demonstrate that expression of HMGR mRNA …
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Detection of periodontal bacteria in atherosclerotic plaque
… SREBP2 and its two target transcripts, LDLR and HMGR. Similarly, the cholesterol transporter gene ABCA1 was highly expressed in P. acnes-infected THP-1 cells in addition to inflammatory cytokines/chemokines TNFα, IL-1β, CCL3 (MIP-1α), cell adhesion molecule ICAM-1. Anti-apoptotic gene BCL2A1 …
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Combinatorial biochemistry of triterpene saponins in plants
… 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the enzyme catalyzing the rate-limiting step in the mevalonate pathway, for ubiquitin-mediated proteasomal degradation, thereby controlling saponin biosynthesis.
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Breaking the MF curse: the regulatory role of the Methyl farnesoate – MEKRE93 pathway in crustacean molting
… 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), farnesoic acid O-methyltransferase (FAMeT), and FAMeT2. Additionally, a FAMeT2 transcript was also identified in the YO and contains an unconventional domain organization compared to annotated FAMeT. Nonetheless, phylogenetic analysis of each …
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IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM
… regolata dall’enzima HMGCoA reduttasi (HMGR). Considerato il suo ruolo centrale nella regolazione della lipogenesi e della sintesi del colesterolo, ACLY è emerso come un importante target farmacologico. In questo contesto, acido bempedoico, first-in-class inibitore di ACLY approvato in …