Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"HMGA1"”.
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The role of High Mobility Group A1 protein in transcriptional regulation of cellular senescence
… in embryonic, senescent and cancer cells. HMGA1 is a key structural component for SAHF formation. In contrast, it has been suggested that HMGA proteins are involved in gene activation potentially through structurally altering regulatory elements. However, comprehensive understanding of how …
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Butyrat moduliert die Expression der Nicht-Histon-Proteine HMGA1, HMGN1 und HMGN2 in humanen Adenokarzinomzellen des Kolons und des Magens
… des Chromatins. Die vermehrte Expression des HMGA1-Proteins ist eine Gemeinsamkeit vieler humaner Malignome und die HMGA1-Proteinfamilie wurde selbst als neue Gruppe von Onkogenen erkannt. Die HMGA1 Proteine beeinflussen die Expression zahlreicher Gene und stehen selbst wiederum unter der …
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Autonomous and non-autonomous regulation of chromatin structure during cellular senescence
… data have also allowed us to identify a unique HMGA1 binding profile, potentially suggesting a novel role for HMGA1 in gene regulation. Together, our data indicate that NOTCH signalling, both cell-autonomously and non-cell-autonomously, can repress HMGA1, a multi-faceted protein that regulates …
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From Technology to Chromatin Biology: Contemporary Mass Spectrometry of Histones and Chromatin Associated Proteins
… MS to other chromatin-associated proteins like HMGA1. In this study we were able to link PTM dynamics (phosphorylation of Ser 43) on HMGA1a to DNA repair and the early events in apoptosis.
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Dissecting the Architectural Properties of Chromatin and the Influence of the H1 Linker Histone on Chromatin Regulation
… I further studied H1 mobility in H1 and HMGA1-rich settings. Through advanced modelling techniques and multi-disciplinary collaborations, my research provides a valuable contribution to the field of chromatin biology and beyond. My findings could have profound implications for our …