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Showing 1 to 6 of 6 for “"HMGA"”.
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Modulation der Expression von Integrin-Beta4, Interleukin-1Beta und HMGA in humanen kolorektalen Karzinomzellen durch Butyrat
… Interleukin-1ß (Entzündungsfaktor) und HMGA (Transkriptionsfaktor) ab 48 Stunden Inkubationszeit mit 2mmol/l Butyrat in der gut-differenzierten HT-29-, der entdifferenzierten SW-480-Kolonadenokarzinomzelllinie sowie deren Metastasenzelllinie SW-620 zeigen. Unsere Ergebnisse weisen darauf …
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The role of High Mobility Group A1 protein in transcriptional regulation of cellular senescence
… the biological context. High mobility group A (HMGA) proteins are DNA binding proteins that are known to be highly expressed in embryonic, senescent and cancer cells. HMGA1 is a key structural component for SAHF formation. In contrast, it has been suggested that HMGA proteins are involved in …
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Autonomous and non-autonomous regulation of chromatin structure during cellular senescence
… structural component, high-mobility group A (HMGA). Using ATAC-sequencing (assay for transposase accessible chromatin) we demonstrate that nucleosome positioning is substantially altered in RIS and that this re-distribution is also antagonised by NOTCH1, resulting in a distinct chromatin …
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Understanding the molecular mechanism through which aspirated bile triggers chronic Pseudomonas aeruginosa infections in respiratory disease
… and both the pyocyanin (phzS) and pyomelanin (hmgA) biosynthetic pathways. These mutations have been previously described in various clinical isolates of P. aeruginosa. Loss of Pseudomonas Quinolone Signal (PQS) production in the pigmented variants underpinned the loss of redox suppression in …
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Engineering soft matter for cell biology from a biophysical point of view
… a new role of a chromatin regulator protein, HMGA1a, that can undergo liquid-liquid phase separation in the nucleus. This has been achieved by brings together modeling and experiments to arrive at the essential role of intrinsically disordered sequence as well as the protein-DNA interactions. …