Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"HMG-CoA synthase"”.
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The relevance of bacterial isoprenoid biosynthetic pathways for host-microbe interactions
… (RSV) that targets mammalian and bacterial HMG-CoA reductase (HMG-R) for inhibition of MVAL formation. In tandem we identified significant hepatic and intestinal off-target alterations to the murine metabolome indicating alterations in inflammation, bile acid profiles and antimicrobial …
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Hepatic acetogenesis and ketogenesis in neonatal swine
… enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase) increased plasma (insulin) with suckling (patterns opposite that seen in ketotic neonatal rats, e.g.) may in part explain attenuated ketogenic capacity in piglets. Piglets accumulated fatty acid carboxyl-carbon in …
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A study of the protective effects of an aspalathin enriched green rooibos extract on experimentally induced hepatic steatosis
… of beta-oxidation of lipids and reduced HMG-CoA synthase 1 (HMGCS1), the gene regulating cholesterol synthesis. Histology confirmed increased steatosis limited to zone 3 of the liver acinus synonymous with NAFLD. Treatment with GRT did not significantly affect the steatotic severity score …
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THE EFFECT OF DIETARY FIBRE ON HUMAN LIPID METABOLISM
… from the fermentation in the colon. Propionyl-CoA may compete with acetyl-CoA for binding sites on HMG-CoA synthase. Changes in serum glucagon have been reported when SCFA are infused rectally, and propionate is known to have a high affinity for carnitine. Increased glucagon secretion (which …