Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"HMG-CoA reductase inhibitors"”.
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HMG-CoA Reductase Inhibitors Act Synergistically with UCN-01 Through RAS Inhibition
… when administered to leukemia cells along with HmG-CoA reductase inhibitors, mainly the statins. In this study, we demonstrated that exposure of leukemia cell lines to lovastatin (20 uM, 18 hours) and UCN-01 (100 nM, 18 hours) resulted in mitochondria dysfunction, procaspase 3 and 9 cleavage, …
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Cardiovascular Disease: Prevention and Management
… and mortality in the United States. Statins, or HMG-CoA Reductase Inhibitors, are efficacious in reducing major arterial vascular events and also may decrease risk of venous vascular events (venous thromboembolism) in women taking hormone therapy (HT).1–3 However, these drugs have little effect …
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Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration
… the industrialized world. Studies suggest that HMG CoA reductase inhibitors (statins) might slow the progression of dry ARMD to the exudative stage. We set out to determine if statin use reduces the risk of progression to exudative ARMD in a matched case-control study. METHODS: An …
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The impact of physical activity on statin-associated skeletal muscle myopathy
BACKGROUND: HMG-CoA reductase inhibitors (statins) are a common and effective pharmacological means of treating hypercholesterolemia and decreasing cardiovascular risk. The most common side effect of statins is skeletal muscle myopathy, which appears to be exacerbated by exercise. PURPOSE: The …
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Achievement of secondary prevention goals 6 to 9 months after Acute Coronary Syndrome : a retrospective, cross-sectional analysis
… of secondary prevention medications (aspirin, HMG-CoA reductase inhibitors [statins], beta-blockers and angiotensin-converting enzyme inhibitors [ACEIs] or angiotensin receptor blockers [ARBs]) and smoking cessation in patients after acute coronary syndromes. At present, little is known about …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… such as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (i.e., statins). Development of Oatp1a4 as a transporter target that can be exploited for improved treatment of neurological diseases requires a rigorous characterization of the “molecular machinery” that controls its …
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Evaluation of Food Effects on the Oral Pharmacokinetics of Rosuvastatin
Rosuvastatin is commonly prescribed for the treatment of hypercholesterolemia and exerts its effect through targeted accumulation in the liver. Current United States and Canadian dosing guidelines indicate no preference for fed or fasted rosuvastatin administration. In this study, we demonstrate …