Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"HMG-CoA reductase inhibitor"”.
-
Adhesive and signaling mechanisms in abdominal sepsis
… sepsis-caused lung damage. We observed that HMG-CoA reductase inhibitor regulates pulmonary accumulation of neutrophils via antagonizing CD40 ligand secretion from platelets and via decreasing CXC chemokine formation in the lung. Moreover, HMG-CoA reductase inhibition maintained CD4 T-cell …
-
Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice
… genes, and enhancing the degradation of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis. We first created Insig-double-knockout (Insig-DKO) mice homozygous for null mutations in Insig-1 and Insig-2. Insig-DKO mice exhibited defects in midline facial fusion, ranging …
-
Alteration of prenylation: Effect on neurite outgrowth and Rho GTPase signaling
… of the 3-hydroxy-3-methyglutaryl coenyzme A (HMG-CoA) reductase inhibitor, lovastatin, promotes neurite outgrowth in some systems and inhibits it in others (Schulz et al., 2004; Holmberg et al., 2006). Anecdotally, lovastatin also contradictorily relieves or exacerbates memory loss in …
-
The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… therapeutic target but, as p38 MAP kinase inhibitors are not established for clinical use, work was proposed to better characterise this pathway and identify agent(s) which may inhibit p38 MAPK indirectly. The HMG-CoA reductase inhibitor simvastatin was recently shown to inhibit hypoxic …
-
Chemoprevention in Kidney Cancer
Background: This thesis is a composition of three studies that explore the role of statins in kidney cancer. Furthermore, I evaluate the potential for different interpretations from the same data depending on the method of classifying medication use. Methods: The first study was a population-based …