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Showing 1 to 20 of 42 for “"HMG-CoA reductase"”.

  1. Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase

    Menzies, SamUniversity of Cambridge2018

    … of MHC class I molecules. The ER-resident enzyme HMG-CoA reductase (HMGCR) catalyses the rate-limiting step in the cholesterol biosynthesis pathway and is targeted therapeutically by statins. To maintain cholesterol homeostasis, the expression of HMGCR is tightly regulated by sterols …

    cambridge Repository record

  2. HMG-CoA Reductase Inhibitors Act Synergistically with UCN-01 Through RAS Inhibition

    Khanna, Payal2014

    … when administered to leukemia cells along with HmG-CoA reductase inhibitors, mainly the statins. In this study, we demonstrated that exposure of leukemia cell lines to lovastatin (20 uM, 18 hours) and UCN-01 (100 nM, 18 hours) resulted in mitochondria dysfunction, procaspase 3 and 9 cleavage, …

    vcu Repository record

  3. Understanding and Harnessing the Structural Features that Govern HMG-CoA Reductase Activity

    Ragwan, Edwin

    … enzyme 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR), which catalyzes the reduction of HMG-CoA to mevalonate using two equivalents of the cofactor NAD(P)H, is part of the mevalonate pathway, found in all kingdoms of life. This pathway is at the heart of natural product biosynthesis …

    bryn-mawr Repository record

  4. Effects of HMG-CoA reductase inhibitors on proliferation and differentiation of human primary osteoblast-like cells

    이, 미덕2011

    Master

    ajou Repository record

  5. Sequential Actions of VCP/p97 and the Proteasome 19S Regulatory Particle in Sterol-Accelerated, ER-Associated Degradation of HMG CoA Reductase

    Morris, Lindsey LaChelle2016

    … (ERAD) of the cholesterol biosynthetic enzyme HMG CoA reductase results from its sterol-induced binding to ER membrane proteins called Insig-1 and Insig-2. This binding allows for subsequent ubiquitination of reductase by Insig-associated ubiquitin ligases. Once ubiquitinated, reductase becomes …

    utswmed Repository record

  6. The cloning and molecular regulation of rat 3-hydroxy-3-methylglutaryl coenzyme A reductase

    Williams, David LeeUniversity of Illinois at Urbana-Champaign2011

    We have cloned and sequenced the cDNA for rat HMG-CoA reductase the key regulatory enzyme in the mevalonate pathway. The amino acid sequence of rat HMG-CoA reductase is highly homologous to hamster and human reductases. Noncoding regions of the reductase mRNAs are also highly conserved. Rat HMG-CoA …

    uiuc Repository record

  7. Regulation of Cholesterol Biosynthesis in Hepatocytes

    Enns, Jennifer Emily2010

    … hepatic cholesterol synthesis by inhibiting HMG-CoA reductase, the enzyme which catalyzes the rate-limiting step of the cholesterol synthesis pathway. Several natural compounds were screened using the human hepatoma cell line HepG2. One compound, berberine, showed great potential as a …

    manitoba Repository record

  8. Cloning and regulation of rat and Xenopus laevis hepatic 3-hydroxy-3-methylglutaryl Coenzyme A reductase

    Chen, HangjiongUniversity of Illinois at Urbana-Champaign2011

    … laevis 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase have been cloned and sequenced. The rat liver HMG-CoA reductase cDNA clone contains one open reading frame coding for 887 amino acids. Its 106 nucleotide long 5$\sp\prime$-noncoding region contains no additional start codons. It …

    uiuc Repository record

  9. Adhesive and signaling mechanisms in abdominal sepsis

    Zhang, SuSection for Surgery, Clinical Sciences, Malmö2012

    … sepsis-caused lung damage. We observed that HMG-CoA reductase inhibitor regulates pulmonary accumulation of neutrophils via antagonizing CD40 ligand secretion from platelets and via decreasing CXC chemokine formation in the lung. Moreover, HMG-CoA reductase inhibition maintained CD4 T-cell …

    lund Repository record

  10. Impact of delta-tocotrienol on human melanoma cell proliferation

    Fernandes, Nicolle ValerieTexas Woman's University2010

    … pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides essential intermediates for the prenylation or dolichylation of growth-related proteins including nuclear Ras, nuclear lamins, and growth factor receptors. d-δ-tocotrienol, a post-transcriptional down-regulator of HMG …

    twu Repository record

  11. Studies on the Regulation of Hepatic Hmg Coenzyme a Reductase and the Production of Anti-Hmg-Coenzyme a Reductase Monoclonal Antibodies

    Clark, Robert EarlUniversity of Illinois at Urbana-Champaign2014

    … for the purpose of studying the regulation of HMG-CoA reductase.

    uiuc Repository record

  12. Role of Insig-Mediated Cholesterol Homeostasis in the Development of the Palate and Hair Follicles in Mice

    Evers, Bret Michael2012

    … genes, and enhancing the degradation of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis. We first created Insig-double-knockout (Insig-DKO) mice homozygous for null mutations in Insig-1 and Insig-2. Insig-DKO mice exhibited defects in midline facial fusion, ranging …

    utswmed Repository record

  13. Utilizing Drosophila S2 Cells as a Model System to Determine Underlying Mechanisms of ER-associated Degradation

    Faulkner, Rebecca Ann2016

    … the ERAD of integral membrane proteins, HMG CoA reductase and Insig-1. These are ideal model substrates since their ERAD is strictly regulated by lipids, which helps guard against artifacts when various aspects of the reactions are reconstituted in model systems or in vitro. I utilized …

    utswmed Repository record

  14. Anti-hyperlipidemic activities of Ilex latifolia and other selected herbs

    Saleh, AliLondon Metropolitan University2016

    … parts of the project focused on its effect on HMG-CoA reductase expression, and on LDL receptor expression in HepG2 and AML-12 hepatocytes. Ilex latifolia effect on mitochondrial metabolism, and glucose uptake was assayed in HepG2 and AML-12 hepatocytes. Chapter I is an introduction to …

    london-metro Repository record

  15. AMPK Regulation of Myeloid Inflammatory Responses During Acute and Chronic Disease

    Smith, TylerUniversité d'Ottawa / University of Ottawa2025

    … of AMPK in the cholesterol synthesis pathway, HMG-CoA reductase, which has links to the cholesterol-driven pathology of atherosclerosis. By using a combination of mouse and cell models that lack the inhibitory AMPK phosphorylation site on HMG-CoA reductase, we establish that this signaling axis …

    ottawa-retro Repository record

  16. Mechanism of Rare Variant In Acta2, P.Arg149Cys, Driving Diverse Vascular Disease

    Kaw, Kaveeta, <p><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__orcid.org_0000-2D0002-2D6456-2D8004&d=DwMFaQ&c=bKRySV-ouEg_AT-w2QWsTdd9X__KYh9Eq2fdmQDVZgw&r=MRy6YVHLlKjxbLywSLvrZZ1Q8MsFZLqehpe6wFL2Tho&m=QK_GwCqbJOUnLTUI3TkA6Yz1FIQUeZ-TsPueMsT04Cs&s=CGvi6syV6qbY6yCnf0qczowIKpWwx9tghOsCUr_rS_I&e=" target="_blank">https://orcid.org/0000-0002-6456-8004</a></p>2023

    … through increased levels and activity of HMG CoA reductase. The increased cellular cholesterol levels lead to ER stress, thus engaging an UPR and PERK activation and modulation in the absence of exogenous cholesterol. To confirm a role of Hsf1-induced HMG CoA reductase in the increased …

    uthsc Repository record

  17. Cardiovascular Disease: Prevention and Management

    Davis, John WilliamThe University of Texas Medical Branch at Galveston2022

    … and mortality in the United States. Statins, or HMG-CoA Reductase Inhibitors, are efficacious in reducing major arterial vascular events and also may decrease risk of venous vascular events (venous thromboembolism) in women taking hormone therapy (HT).1–3 However, these drugs have little effect …

    utmb Repository record

  18. Combined Inhibition of SREBP and m-TORC1 Signaling Synergistically Inhibits the Proliferation of B Cell Lymphoma

    Zhu, Zhenhan2024

    … SREBP signaling or its downstream target HMG-CoA reductase (HMGCR) using Fatostatin or Simvastatin effectively restrains the proliferation of B cell lymphoma cells. However, B cell lymphoma cells activate the mTORC1-pS6 pathway in response to statin treatment, suggesting a possible …

    iupui Repository record

  19. Protective Effect of Statin Use in the Progression of Dry to Exudative Age-Related Macular Degeneration

    Nettune, Gregory2010

    … the industrialized world. Studies suggest that HMG CoA reductase inhibitors (statins) might slow the progression of dry ARMD to the exudative stage. We set out to determine if statin use reduces the risk of progression to exudative ARMD in a matched case-control study. METHODS: An …

    utswmed Repository record

  20. Life Style, Molecular Pathology, and Breast Cancer Risk

    Borgquist, SignePathology (Malmö)2008

    … PgR+, but negative ERβ expression. The enzyme HMG-CoA reductase was differentially expressed in breast cancer and high expression was associated with a smaller tumour size, low grade, low proliferation, and expression of ERα and ERβ, but not PgR. Estrogen-related factors, such as obesity and …

    lund Repository record

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